A novel angiotensin I-converting enzyme mutation (S333W) impairs N-domain enzymatic cleavage of the anti-fibrotic peptide, AcSDKP.

Autor: Sergei M Danilov, Michael S Wade, Sylva L Schwager, Ross G Douglas, Andrew B Nesterovitch, Isolda A Popova, Kyle D Hogarth, Nakul Bhardwaj, David E Schwartz, Edward D Sturrock, Joe G N Garcia

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e88001 (2014)

BACKGROUND: Angiotensin I-converting enzyme (ACE) has two functional N- and C-domain active centers that display differences in the metabolism of biologically-active peptides including the hemoregulatory tetrapeptide, Ac-SDKP, hydrolysed preferential

Externí odkaz: https://doaj.org/article/ffe120ace2814c07ab74584edaa8d8c5

The Angiotensin AT2Receptor: From a Binding Site to a Novel Therapeutic Target

Autor: U. Muscha Steckelings, Robert E. Widdop, Edward D. Sturrock, Lizelle Lubbe, Tahir Hussain, Elena Kaschina, Thomas Unger, Anders Hallberg, Robert M. Carey, Colin Sumners

Publikováno v: Pharmacological Reviews. 74:1051-1135

Discovered more than 30 years ago, the angiotensin AT2 receptor (AT2R) has evolved from a binding site with unknown function to a firmly established major effector within the protective arm of the renin-angiotensin system (RAS) and a target for new d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed01bea095fdd625441059db2d80f05
https://doi.org/10.1124/pharmrev.120.000281

Probing the Requirements for Dual Angiotensin-Converting Enzyme C-Domain Selective/Neprilysin Inhibition

Autor: Lauren B. Arendse, Gyles E. Cozier, Charles J. Eyermann, Gregory S. Basarab, Sylva L. Schwager, Kelly Chibale, K. Ravi Acharya, Edward D. Sturrock

Publikováno v: Arendse, L B, Cozier, G, Eyermann, C, Basarab, G, Schwager, S L U, Chibale, K, Acharya, R & Sturrock, E D 2022, ' Probing the requirements for dual angiotensin-converting enzyme C-domain selective/neprilysin inhibition ', Journal of Medicinal Chemistry, vol. 65, no. 4, pp. 3371-3387 . https://doi.org/10.1021/acs.jmedchem.1c01924

Selective inhibition of the angiotensin-converting enzyme C-domain (cACE) and neprilysin (NEP), leaving the ACE N-domain (nACE) free to degrade bradykinin and other peptides, has the potential to provide the potent antihypertensive and cardioprotecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58cd177ad72f4cc61dfcddd02a716f09
https://doi.org/10.1021/acs.jmedchem.1c01924

Novel ACE mutations mimicking sarcoidosis by increasing blood ACE levels

Autor: Chananya Goldman, Laine Y. Francuzevitch, Edward D. Sturrock, Marc A. Judson, Mark Jain, L M Samokhodskaya, Rachel Vancavage, Zarema Arbieva, Sergei M. Danilov, Steven M. Dudek, A A Kamalov, Pavel A. Petukhov, Maria DiSanto-Rose

Publikováno v: Translational Research. 230:5-20

An elevated blood angiotensin I-converting enzyme (ACE) supports diagnosis of sarcoidosis and Gaucher disease. However, some ACE mutations increase ACE shedding, and patients with these mutations are therefore at risk of being incorrectly diagnosed w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ebc2fbbca78e56e3efd06f06c50665
https://doi.org/10.1016/j.trsl.2020.07.010

Author response for 'Structural basis for the inhibition of human angiotensin‐1 converting enzyme by fosinoprilat'

Autor: null Gyles E. Cozier, null Emma C. Newby, null Sylva L. U. Schwager, null R. Elwyn Isaac, null Edward D. Sturrock, null K. Ravi Acharya

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74439a198717789b50896599edf31b12
https://doi.org/10.1111/febs.16543/v2/response1