Zobrazeno 1 - 10
of 450
pro vyhledávání: '"Edward Chu"'
Autor:
Chenxi Gao, Huaibin Ge, Shih-Fan Kuan, Chunhui Cai, Xinghua Lu, Farzad Esni, Robert E Schoen, Jing H Wang, Edward Chu, Jing Hu
Publikováno v:
eLife, Vol 13 (2024)
BRAFV600E mutation is a driver mutation in the serrated pathway to colorectal cancers. BRAFV600E drives tumorigenesis through constitutive downstream extracellular signal-regulated kinase (ERK) activation, but high-intensity ERK activation can also t
Externí odkaz:
https://doaj.org/article/e2a122bab7f34dd78f4661a9fc648667
Publikováno v:
Biochemistry and Biophysics Reports, Vol 37, Iss , Pp 101634- (2024)
BRAF mutation is a driver mutation in colorectal cancer (CRC), and BRAFV600E mutation is found in 10–15 % of all CRCs. BRAF mutant CRCs in patients are primarily localized in the right colon, including the cecum. However, in the Vill-Cre;BRAFV600E/
Externí odkaz:
https://doaj.org/article/226cf0b55c064242b0d219a745172959
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 7, Pp 2826-2843 (2023)
Aurora kinase A (Aurora-A), a serine/threonine kinase, plays a pivotal role in various cellular processes, including mitotic entry, centrosome maturation and spindle formation. Overexpression or gene-amplification/mutation of Aurora-A kinase occurs i
Externí odkaz:
https://doaj.org/article/695e21de14304c01b520177a1eaf0b4e
Autor:
Haizhou Liu, Hui Liu, Zhiyi Zhou, Jessica Chung, Guojing Zhang, Jin Chang, Robert A. Parise, Edward Chu, John C. Schmitz
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-13 (2023)
Abstract Fluoropyridine-based chemotherapy remains the most widely used treatment for colorectal cancer (CRC). In this study, we investigated the mechanism by which the natural product Scutellaria baicalensis (Huang Qin; HQ) and one of its main compo
Externí odkaz:
https://doaj.org/article/b24a62d91f2941db9a6b6fb2e0645ba8
Autor:
Astha Thakkar, Kith Pradhan, Benjamin Duva, Juan Manuel Carreno, Srabani Sahu, Victor Thiruthuvanathan, Sean Campbell, Sonia Gallego, Tushar D Bhagat, Johanna Rivera, Gaurav Choudhary, Raul Olea, Maite Sabalza, Lauren C Shapiro, Matthew Lee, Ryann Quinn, Ioannis Mantzaris, Edward Chu, Britta Will, Liise-anne Pirofski, Florian Krammer, Amit Verma, Balazs Halmos
Publikováno v:
eLife, Vol 12 (2023)
Background: Cancer patients show increased morbidity with COVID-19 and need effective immunization strategies. Many healthcare regulatory agencies recommend administering ‘booster’ doses of COVID-19 vaccines beyond the standard two-dose series, f
Externí odkaz:
https://doaj.org/article/6208af8c6b20451080ddc36e3a95392b
Autor:
Chenxi Gao, Guangming Chen, Dennis Han Zhang, Judy Zhang, Shih-Fan Kuan, Wenhuo Hu, Farzad Esni, Xuan Gao, Jun-Lin Guan, Edward Chu, Jing Hu
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 8, Iss 4, Pp 561-578 (2019)
Background & Aims: Identification and validation of new functionally relevant and pharmacologically actionable targets for pancreatic ductal adenocarcinoma (PDAC) remains a great challenge. Premalignant acinar cell reprogramming (acinar-to-ductal met
Externí odkaz:
https://doaj.org/article/9b0a9f3766f74e40b89576bec27edfa5
Autor:
Meredith Furst, Edward Chu, Kendall Wannamaker, Brian Planchard, Lisa Pacheco, Laura Vigil, Tarana Ahmed, Daniel Johnson, Corey Waldman
Publikováno v:
Journal of Academic Ophthalmology, Vol 12, Iss 02, Pp e273-e276 (2020)
Objective The aim of the study is to determine the effects of scribes on efficiency in an academic ophthalmology practice. Design This is a quality improvement study conducted by two ophthalmologists at an academic ophthalmology practice at UT Health
Externí odkaz:
https://doaj.org/article/27acbe58cb144977911df4f00bf0dfee
Publikováno v:
Cell Communication and Signaling, Vol 16, Iss 1, Pp 1-12 (2018)
Abstract Background 5-Fluorouracil (5-FU) remains the most widely used agent to treat colorectal cancer (CRC). However, its clinical efficacy is currently limited by the development of drug resistance. Traditional Chinese Herbal Medicine (TCM) has be
Externí odkaz:
https://doaj.org/article/453ed2ad559649b8b0c061d3ed8a378d
Autor:
Enriqueta Felip, Josep Tabernero, Maria De Santis, Emile Voest, Mark Robson, Fatima Cardoso, Elisabeth G E de Vries, Fedro Alessandro Peccatori, Svetlana Jezdic, Giannis Mountzios, Smita Bhatia, Alexandru Eniu, Luzia Travado, Ulrich Keilholz, Jonas Bergh, Jan Buckner, Friedrich Stiefel, Ahmad Awada, Cristiana Sessa, Olivier Michielin, Marc Ernstoff, Ben Markman, Lisa Licitra, Rossana Berardi, Jill Gilbert, Lidia Schapira, Eva Schernhammer, Jeffrey S Weber, Heinz-Josef Lenz, Piotr Rutkowski, Jennifer Duff, Axel Grothey, Yuichiro Ohe, Saskia Litiere, Hans Wildiers, Christian Dittrich, Michael Kosty, Doug Pyle, Nagi El-Saghir, Jean-Pierre Lotz, Pia Österlund, Nicholas Pavlidis, Gunta Purkalne, Susana Banerjee, Jan Bogaerts, Paolo Casali, Edward Chu, Julia Lee Close, Bertrand Coiffier, Roisin Connolly, Sarah Coupland, Luigi De Petris, Don S Dizon, Linda R Duska, Martin F Fey, Nicolas Girard, Andor W J M Glaudemans, Priya K Gopalan, Stephen M Hahn, Diana Hanna, Christian Herold, Jørn Herrstedt, Krisztian Homicsko, Dennie V Jones, Lorenz Jost, Saad Khan, Alexander Kiss, Claus-Henning Köhne, Rainer Kunstfeld, Stuart Lichtman, Thomas Lion, Lifang Liu, Patrick J Loehrer, Merry Jennifer Markham, Marius Mayerhoefer, Johannes G Meran, Elizabeth Charlotte Moser, Timothy Moynihan, Torsten Nielsen, Kjell Öberg, Antonio Palumbo, Michael Pfeilstöcker, Chandrajit Raut, Scot C Remick, Roberto Salgado, Martin Schlumberger, Hans-Joachim Schmoll, Lowell Schnipper, Charles L Shapiro, Julie Steele, Cora N Sternberg, Florian Strasser, Roger Stupp, Richard Sullivan, Marcel Verheij, Everett Vokes, Jamie Von Roenn, Yosef Yarden
Publikováno v:
ESMO Open, Vol 1, Iss 5 (2016)
The European Society for Medical Oncology (ESMO) and the American Society of Clinical Oncology (ASCO) are publishing a new edition of the ESMO/ASCO Global Curriculum (GC) thanks to contribution of 64 ESMO-appointed and 32 ASCO-appointed authors. Firs
Externí odkaz:
https://doaj.org/article/03442ec458e245ef83ebe8453a3f265c
Autor:
Yuyan Zhang, Shaoli Yang, Ming Liu, Chunxia Song, Ning Wu, Peixue Ling, Edward Chu, Xiukun Lin
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10618 (2010)
Thymidylate synthase (TS), which catalyzes the de novo synthesis of dUMP, is an important target for cancer therapy. In this report, the effects of 5-fluorouracil (5-FU) and ZD1694 on the regulation of TS gene expression were evaluated in zebrafish e
Externí odkaz:
https://doaj.org/article/0b64de74814e4a5dbbdb9426a5765a20