A Reactivity-Based 18F-Labeled Probe for PET Imaging of Oxidative Stress in Chemotherapy-Induced Cardiotoxicity

Autor: Pragalath Sadasivam, Filipa Mota, Victoria R. Pell, Richard Southworth, Nisha Singh, Ran Yan, Friedrich Baark, Edward C. T. Waters

Publikováno v: Mota, F, Pell, V, Singh, N, Baark, F, Waters, E, Sadasivam, P, Southworth, R & Yan, R 2022, ' A reactivity-based 18F-labeled probe for PET imaging of oxidative stress in chemotherapy-induced cardiotoxicity ', Molecular Pharmaceutics, vol. 19, no. 1, pp. 18-25 . https://doi.org/10.1021/acs.molpharmaceut.1c00496

Oxidative stress underlies the pathology of many human diseases, including the doxorubicin-induced off-target cardiotoxicity in cancer chemotherapies. Since current diagnostic procedures are only capable of monitoring cardiac function, a noninvasive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b44aa5d990616c20e0f8d6936a553de
https://doi.org/10.1021/acs.molpharmaceut.1c00496

Synthesis and ex vivo biological evaluation of gallium-68 labelled NODAGA chelates assessing cardiac uptake and retention

Autor: Edward C. T. Waters, Nicholas J. Long, Friedrich Baark, Bradley E. Osborne, Thomas T. C. Yue, Richard Southworth

Publikováno v: Dalton Transactions. 50:14695-14705

Radiolabelled lipophilic cations can be used to non-invasively report on mitochondrial dysfunction in diseases such as cardiovascular disease, cardiotoxicity and cancer. Several such lipophilic cations are currently used clinically to map myocardial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f2dbb50888df02f587ee0abcf88c1294
https://doi.org/10.1039/d1dt02224e

Detecting Validated Intracellular ROS Generation with

Autor: Edward C T, Waters, Friedrich, Baark, Zilin, Yu, Filipa, Mota, Thomas R, Eykyn, Ran, Yan, Richard, Southworth

Publikováno v: Molecular imaging and biology. 24(3)

To determine the sensitivity of theThe sensitivity of [[[

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4897aeb4353c96be5095c03e66e410ea
https://pubmed.ncbi.nlm.nih.gov/34820762

Non-invasive imaging of mitochondrial dysfunction and anthracycline cardiotoxicity by repurposing 99mTc Sestamibi SPECT imaging

Autor: Edward C. T. Waters, Filipa Mota, Z. Saffee, Thomas R. Eykyn, Richard Southworth, James Clark, Victoria R. Pell, F. Baark

Publikováno v: Journal of Molecular and Cellular Cardiology. 120:32

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::529115d7135be81188b712aea9110de5
https://doi.org/10.1016/j.yjmcc.2018.05.100

Detecting Validated Intracellular ROS Generation with ¹⁸F-dihydroethidine-Based PET.

Autor: Waters, Edward C. T., Baark, Friedrich, Yu, Zilin, Mota, Filipa, Eykyn, Thomas R., Yan, Ran, Southworth, Richard

Publikováno v: Molecular Imaging & Biology; Jun2022, Vol. 24 Issue 3, p377-383, 7p