Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Edward C. Stites"'
Autor:
Michael Trogdon, Kodye Abbott, Nadia Arang, Kathryn Lande, Navneet Kaur, Melinda Tong, Mathieu Bakhoum, J. Silvio Gutkind, Edward C. Stites
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-17 (2024)
Abstract Mathematical models of biochemical reaction networks are an important and emerging tool for the study of cell signaling networks involved in disease processes. One promising potential application of such mathematical models is the study of h
Externí odkaz:
https://doaj.org/article/0b29339706f74b9f85438ba20cdd4062
Autor:
Thomas McFall, Michael Trogdon, Anita C. Guizar, John F. Langenheim, Laura Sisk-Hackworth, Edward C. Stites
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-7 (2022)
Abstract The combination of KRAS G12C inhibitors with EGFR inhibitors has reproducibly been shown to be beneficial. Here, we identify another benefit of this combination: it effectively inhibits both wild-type and mutant RAS. We believe that targetin
Externí odkaz:
https://doaj.org/article/d2a834aeeb10413aae877a20897f77b6
Autor:
Yuriy Baglaenko, Catriona Wagner, Vijay G. Bhoj, Petter Brodin, M. Eric Gershwin, Daniel Graham, Pietro Invernizzi, Kenneth K. Kidd, Ilya Korsunsky, Michael Levy, Andrew L. Mammen, Victor Nizet, Francisco Ramirez-Valle, Edward C. Stites, Marc S. Williams, Michael Wilson, Noel R. Rose, Virginia Ladd, Marina Sirota
Publikováno v:
Cambridge Prisms: Precision Medicine, Vol 1 (2023)
Precision Medicine is an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle. Autoimmune diseases are those in which the body’s natural defense system loses disc
Externí odkaz:
https://doaj.org/article/bcf797b4c46e41e2bed7e76f1a48f825
Publikováno v:
Molecular & Cellular Oncology, Vol 9, Iss 1 (2022)
Genome sequenced samples from cancer patients helped identify roles of different mutation types and enabled targeted therapy development. However, critical questions like what are the gene mutation rates among the patients? or what genes are most com
Externí odkaz:
https://doaj.org/article/b851a127b3d54de68181f6bb07978732
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Understanding the frequency of gene mutations in cancer could be important for generating targeted therapeutics. Here, the authors use SEER data and cancer genomics data from TCGA to estimate the gene mutation frequencies in the US cancer population.
Externí odkaz:
https://doaj.org/article/96a05c2ccaa14a278d08812685fc5078
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-7 (2020)
Abstract Phase three clinical trial evidence suggests that colorectal cancers with the KRAS G13D mutation may benefit from EGFR inhibitors, like cetuximab, in contrast to the other most common KRAS mutations. A mechanism to explain why this mutation
Externí odkaz:
https://doaj.org/article/7cc8b0a5e5f043cda4dd6ca790b86978
Autor:
Thomas McFall, Edward C. Stites
Publikováno v:
Cell Reports, Vol 37, Iss 11, Pp 110096- (2021)
Summary: Mutations can be important biomarkers that influence the selection of specific cancer treatments. We recently combined mathematical modeling of RAS signaling network biochemistry with experimental cancer cell biology to determine why KRAS G1
Externí odkaz:
https://doaj.org/article/b8f260267e2e452e895b857460324e47
Autor:
Elpiniki Nikolopoulou, Lauren R. Johnson, Duane Harris, John D. Nagy, Edward C. Stites, Yang Kuang
Publikováno v:
Letters in Biomathematics, Vol 5, Iss 0, Pp S137-S159 (2018)
The use of immune checkpoint inhibitors is becoming more commonplace in clinical trials across the nation. Two important factors in the tumour-immune response are the checkpoint protein programmed death-1 (PD-1) and its ligand PD-L1. We propose a mat
Externí odkaz:
https://doaj.org/article/4cb3caa303564b2486bd7010cfd6f73c
Publikováno v:
Cell Reports, Vol 10, Iss 3, Pp 307-316 (2015)
Cancer develops after the acquisition of a collection of mutations that together create the cancer phenotype. How collections of mutations work together within a cell and whether there is selection for certain combinations of mutations are not well u
Externí odkaz:
https://doaj.org/article/ef4eeeca110c40aab8baf913389085b1
Autor:
Edward C. Stites
Publikováno v:
Methods in Molecular Biology ISBN: 9781071630075
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a4eb6c4927c0df9e3a2f99529a2712c
https://doi.org/10.1007/978-1-0716-3008-2_15
https://doi.org/10.1007/978-1-0716-3008-2_15