Zobrazeno 1 - 10
of 157
pro vyhledávání: '"Edward C. Hsiao"'
Autor:
Lin Qi, Marko Groeger, Aditi Sharma, Ishan Goswami, Erzhen Chen, Fenmiao Zhong, Apsara Ram, Kevin Healy, Edward C. Hsiao, Holger Willenbring, Andreas Stahl
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Interactions between adipose tissue, liver and immune system are at the center of metabolic dysfunction-associated steatotic liver disease and type 2 diabetes. To address the need for an accurate in vitro model, we establish an interconnecte
Externí odkaz:
https://doaj.org/article/278065363b2c41c582d81e0c6481a1ce
Publikováno v:
American Journal of Ophthalmology Case Reports, Vol 36, Iss , Pp 102167- (2024)
Purpose: To describe the use of anti-osteoclastic medications (i.e., bisphosphonates and receptor activator of nuclear factor kappa beta (RANK) ligand inhibitors) in treating choroidal osteoma. Methods: A 42-year-old male with bilateral posterior cho
Externí odkaz:
https://doaj.org/article/bf63f2f1d4f34bd589f9f48a685d6f1b
Autor:
Robert J. Pignolo, Mona Al Mukaddam, Geneviève Baujat, Matthew A. Brown, Carmen De Cunto, Edward C. Hsiao, Richard Keen, Kim-Hanh Le Quan Sang, Donna R. Grogan, Rose Marino, Andrew R. Strahs, Frederick S. Kaplan
Publikováno v:
BMC Medical Research Methodology, Vol 23, Iss 1, Pp 1-13 (2023)
Abstract Background The design of clinical trials in rare diseases is often complicated by a lack of real-world translational knowledge. Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic disorder characterized by skeletal malformat
Externí odkaz:
https://doaj.org/article/3d06cf9e3e804e1d98d678d462963546
Autor:
Marko Groeger, Koji Matsuo, Emad Heidary Arash, Ashley Pereira, Dounia Le Guillou, Cindy Pino, Kayque A. Telles-Silva, Jacquelyn J. Maher, Edward C. Hsiao, Holger Willenbring
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Hepatic insulin resistance is recognized as a driver of type 2 diabetes and fatty liver disease but specific therapies are lacking. Here we explore the potential of human induced pluripotent stem cells (iPSCs) for modeling hepatic insulin re
Externí odkaz:
https://doaj.org/article/ca63e7ea8e914071b9f2810f9b4f1a48
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 18, Iss 1, Pp 1-5 (2023)
Abstract Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder associated with increased immune activity and severe, progressive heterotopic ossification. We previously described a cohort of 32 patients with FOP who were either expos
Externí odkaz:
https://doaj.org/article/70cb151f9262437bb90b40fd54b216f2
Autor:
Conan Juan, Alec C. Bancroft, Ji Hae Choi, Johanna H. Nunez, Chase A. Pagani, Yen-Sheng Lin, Edward C. Hsiao, Benjamin Levi
Publikováno v:
Biomolecules, Vol 14, Iss 3, p 349 (2024)
Heterotopic ossification (HO) is a debilitating pathology where ectopic bone develops in areas of soft tissue. HO can develop as a consequence of traumatic insult or as a result of dysregulated osteogenic signaling, as in the case of the orphan disea
Externí odkaz:
https://doaj.org/article/20a9d46336114fc692485c94f86cba2f
Publikováno v:
Biomolecules, Vol 14, Iss 3, p 357 (2024)
Background: Inflammation is a major driver of heterotopic ossification (HO), a condition of abnormal bone growth in a site that is not normally mineralized. Purpose of review: This review will examine recent findings on the roles of inflammation and
Externí odkaz:
https://doaj.org/article/e9936f25492d40fcb510e32b61ccdea2
Autor:
Samuel Kou, Sammi Kile, Sai Samhith Kambampati, Evelyn C. Brady, Hayley Wallace, Carlos M. De Sousa, Kin Cheung, Lauren Dickey, Kelly L. Wentworth, Edward C. Hsiao
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 17, Iss 1, Pp 1-12 (2022)
Abstract Background COVID-19, caused by the SARS-CoV-2 virus, is a severe inflammatory condition. Patients with pre-existing conditions including diabetes, hypertension, and cardiovascular disease are at particularly high risk of complications. Fibro
Externí odkaz:
https://doaj.org/article/780dd5b0e3a042889da91f962e023db8
Autor:
Robert J. Pignolo, Edward C. Hsiao, Genevieve Baujat, David Lapidus, Adam Sherman, Frederick S. Kaplan
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-8 (2021)
Abstract Background Fibrodysplasia ossificans progressiva (FOP), an ultra-rare, progressive, and permanently disabling disorder of extraskeletal ossification, is characterized by episodic and painful flare-ups and irreversible heterotopic ossificatio
Externí odkaz:
https://doaj.org/article/8758ae48b7344bd594990cbe0ed04f6c
Autor:
Samuel Kou, Carmen De Cunto, Geneviève Baujat, Kelly L. Wentworth, Donna R. Grogan, Matthew A. Brown, Maja Di Rocco, Richard Keen, Mona Al Mukaddam, Kim-Hanh le Quan Sang, Umesh Masharani, Frederick S. Kaplan, Robert J. Pignolo, Edward C. Hsiao
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-10 (2020)
Abstract Background Genetic contributors to cardiac arrhythmias are often found in cardiovascular conduction pathways and ion channel proteins. Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare disease of massive heterotopic ossification c
Externí odkaz:
https://doaj.org/article/ecf5cd5133884fc7ab8361ac88baf204