Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Edward C. Cox"'
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33528 (2012)
Motile eukaryotic cells migrate with directional persistence by alternating left and right turns, even in the absence of external cues. For example, Dictyostelium discoideum cells crawl by extending distinct pseudopods in an alternating right-left pa
Externí odkaz:
https://doaj.org/article/114b9a6e7b1145faaa5727b542947873
Publikováno v:
PLoS ONE, Vol 3, Iss 5, p e2093 (2008)
Eukaryotic cells are large enough to detect signals and then orient to them by differentiating the signal strength across the length and breadth of the cell. Amoebae, fibroblasts, neutrophils and growth cones all behave in this way. Little is known h
Externí odkaz:
https://doaj.org/article/f07edbed63c14e279053670e3ae32ef3
Publikováno v:
PLoS Biology, Vol 3, Iss 7, p e229 (2005)
Temperate bacteriophage parasitize their host by integrating into the host genome where they provide additional genetic information that confers higher fitness on the host bacterium by protecting it against invasion by other bacteriophage, by increas
Externí odkaz:
https://doaj.org/article/c98b5462354640abbfb29e79508040c8
Autor:
Robert H. Austin, Edward C. Cox, Henrik Flyvbjerg, Liang Li, Cristian Gradinaru, Jonas Nyvold Pedersen
Publikováno v:
Pedersen, J N, Li, L, Gradinaru, C, Austin, R H, Cox, E C & Flyvbjerg, H 2016, ' How to connect time-lapse recorded trajectories of motile microorganisms with dynamical models in continuous time ', Physical Review E, vol. 94, no. 6, 062401 . https://doi.org/10.1103/PhysRevE.94.062401
We provide a tool for data-driven modeling of motility, data being time-lapse recorded trajectories. Several mathematical properties of a model to be found can be gleaned from appropriate model-independent experimental statistics, if one understands
Autor:
Edward C. Cox, Thomas E. Kuhlman
Publikováno v:
Bioengineered Bugs. 1:298-301
We have developed an easy, reliable two-step method for the insertion of large DNA fragments into any desired location in the E. coli chromosome. The method is based on the recombineering of a small (∼1.3 kbp) “Landing Pad” into the chromosome
Publikováno v:
Proceedings of the National Academy of Sciences. 107:9158-9163
Cells use protein-DNA and protein-protein interactions to regulate transcription. A biophysical understanding of this process has, however, been limited by the lack of methods for quantitatively characterizing the interactions that occur at specific
Autor:
D. Selmeczi, S. F. Nrrelykke, Peter Hagedorn, S. Mosler, Niels Bent Larsen, Lykke Pedersen, Henrik Flyvbjerg, Liang Li, Edward C. Cox
Publikováno v:
The European Physical Journal Special Topics. 157:1-15
The historical co-evolution of biological motility models with models of Brownian motion is outlined. Recent results for how to derive cell-type-specific motility models from experimental cell trajectories are reviewed. Experimental work in progress,
Publikováno v:
Plasmid. 56:145-152
We describe a series of Dictyostelium expression vectors for recombination cloning using the Gateway technology. DNA fragments generated by high fidelity polymerase chain reaction are cloned by topoisomerase-mediated ligation, then recombined into an
Publikováno v:
Developmental Biology. 292:358-370
A key event in Dictyostelium development is the formation of the Mexican hat. This corresponds to a commitment step in morphogenesis that irreversibly signals progression from the slug stage to the fruiting body. We describe the characterization of t
Publikováno v:
Cell. 123(6):1025-1036
SummaryProtein levels have been shown to vary substantially between individual cells in clonal populations. In prokaryotes, the contribution to such fluctuations from the inherent randomness of gene expression has largely been attributed to having ju