Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Edward C Twomey"'
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83421 (2013)
Protein conformational changes are commonly associated with the formation of protein complexes. The non-catalytic death effector domains (DEDs) mediate protein-protein interactions in a variety of cellular processes, including apoptosis, proliferatio
Externí odkaz:
https://doaj.org/article/90d50385f6cf40f1bb5171b2b6002c26
Publikováno v:
IUCrJ, Vol 11, Iss 1, Pp 16-22 (2024)
Molecular structures can be determined in vitro and in situ with cryo-electron microscopy (cryo-EM). Specimen preparation is a major obstacle in cryo-EM. Typical sample preparation is orders of magnitude slower than biological processes. Time-resolve
Externí odkaz:
https://doaj.org/article/18f955e6cb954adf8c07f6242db7a656
Publikováno v:
The Journal of General Physiology
Twomey et al. examine recent structural and functional data that have provided insight into AMPA receptor modulation by TARPs.
Fast excitatory neurotransmission is mediated by the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) subt
Fast excitatory neurotransmission is mediated by the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) subt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::030c8b90a1a33bf0828c5a26f5ec1b08
https://doi.org/10.1085/jgp.201812264
https://doi.org/10.1085/jgp.201812264
Autor:
Edward C, Twomey
Publikováno v:
Nature structuralmolecular biology. 28(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::faede9ca6ef36f52ae74577c373c56df
https://pubmed.ncbi.nlm.nih.gov/34262182
https://pubmed.ncbi.nlm.nih.gov/34262182
Publikováno v:
Biochemistry
Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate the majority of excitatory neurotransmission in the central nervous system. iGluRs open their ion channels in response to binding of the neurotransmitter glutamate, ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::571adab8929bf516220a2d2eb02aa8ca
https://doi.org/10.1021/acs.biochem.7b00891
https://doi.org/10.1021/acs.biochem.7b00891
Autor:
Edward C. Twomey, Jarrod A. Marto, Thomas E. Wales, Nicholas O. Bodnar, Tom A. Rapoport, Scott B. Ficarro, John R. Engen, Zhejian Ji
Publikováno v:
Science. 365
Protein unfolding, one substrate at a time Ubiquitin marks proteins for degradation by the proteasome. However, many substrates cannot be directly degraded because they are well folded or are located in cell membranes or in multimeric complexes. Thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdec27e7d6e0d1607a3e81516e4ade73
https://doi.org/10.1126/science.aax1033
https://doi.org/10.1126/science.aax1033
Autor:
Joachim Frank, Maria V. Yelshanskaya, Edward C. Twomey, Robert A. Grassucci, Alexander I. Sobolevsky
Publikováno v:
Science. 353:83-86
Stargazin and the AMPA receptor AMPA-subtype ionotropic glutamate receptors (AMPARs) mediate fast excitatory neurotransmission and contribute to higher cognitive processes such as learning and memory. In the brain, AMPARs exist as protein-protein com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::768adb59441c08f5ae4a3bbbaf5f096b
https://doi.org/10.1126/science.aaf8411
https://doi.org/10.1126/science.aaf8411
Publikováno v:
Science Advances
Cryo-EM structures of the epithelial calcium channel TRPV6-calmodulin complex reveal a mechanism of Ca2+-induced inactivation.
Calcium (Ca2+) plays a major role in numerous physiological processes. Ca2+ homeostasis is tightly controlled by ion c
Calcium (Ca2+) plays a major role in numerous physiological processes. Ca2+ homeostasis is tightly controlled by ion c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23784cd4eda62dfe710b0311714c79a0
http://europepmc.org/articles/PMC6093632
http://europepmc.org/articles/PMC6093632
Autor:
Appu K. Singh, Luke L. McGoldrick, Robert A. Grassucci, Alexander I. Sobolevsky, Maria V. Yelshanskaya, Kei Saotome, Edward C. Twomey
Publikováno v:
Nature. 553(7687)
Calcium-selective transient receptor potential vanilloid subfamily member 6 (TRPV6) channels play a critical role in calcium uptake in epithelial tissues. Altered TRPV6 expression is associated with a variety of human diseases, including cancers. TRP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c026c450b5a84108d8d1fb9c1f5054c3
https://pubmed.ncbi.nlm.nih.gov/29258289
https://pubmed.ncbi.nlm.nih.gov/29258289