Výsledky vyhledávání - "Edward C Trope"

Akademický článek

The Stapled AKAP Disruptor Peptide STAD-2 Displays Antimalarial Activity through a PKA-Independent Mechanism.

Autor: Briana R Flaherty, Yuxiao Wang, Edward C Trope, Tienhuei G Ho, Vasant Muralidharan, Eileen J Kennedy, David S Peterson

Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0129239 (2015)

Drug resistance poses a significant threat to ongoing malaria control efforts. Coupled with lack of a malaria vaccine, there is an urgent need for the development of new antimalarials with novel mechanisms of action and low susceptibility to parasite

Externí odkaz: https://doaj.org/article/3ff185045f204a87b4fa0ed3fe741960

Zobrazit plný text záznamu

Akademický článek

A comparison of DNA repair pathways to achieve a site-specific gene modification of the Bruton's tyrosine kinase gene

Autor: David H. Gray, Jasmine Santos, Alexandra Grace Keir, Isaac Villegas, Simon Maddock, Edward C. Trope, Joseph D. Long, Caroline Y. Kuo

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 505-516 (2022)

Gene editing utilizing homology-directed repair has advanced significantly for many monogenic diseases of the hematopoietic system in recent years but has also been hindered by decreases between in vitro and in vivo gene integration rates. Homology-d

Externí odkaz: https://doaj.org/article/a50a2f85a4cc440a980c27bee1ffed02

Zobrazit plný text záznamu