Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Edward Bilsky"'
Autor:
Lien D. Nguyen, Luca G. Nolte, Winston J. T. Tan, Denise Giuvelis, Joseph Santos-Sacchi, Edward Bilsky, Barbara E. Ehrlich
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Neuronal calcium sensor 1 (NCS1) regulates a wide range of cellular functions throughout the mammalian nervous systems. Altered NCS1 expression is associated with neurodevelopmental and neurodegenerative diseases. Previous studies focused on
Externí odkaz:
https://doaj.org/article/b6b8f1fb46154bcdb198d9beb1bac578
Autor:
Kirsten M. Raehal, Wolfgang Sadee, Danxin Wang, Emil T. Lin, Edward Bilsky, John J. Lowery, Brigitte L. Kieffer
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 308:512-520
Narcotic analgesics cause addiction by poorly understood mechanisms, involving mu opoid receptor (MOR). Previous cell culture studies have demonstrated significant basal, spontaneous MOR signaling activity, but its relevance to narcotic addiction rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb47621bf3fe066b7606bb2dfa5082c
https://doi.org/10.1124/jpet.103.054049
https://doi.org/10.1124/jpet.103.054049
Publikováno v:
Europe PubMed Central
Repeated exposure to mu-opioid analgesics produces unwanted side effects, including tolerance and physical dependence. delta-Opioid antagonists attenuate development of morphine tolerance and physical dependence. We recently reported that SoRI 9409,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c98f2f90c71ef2004f9f2aa8d0e86189
https://pubmed.ncbi.nlm.nih.gov/11303048
https://pubmed.ncbi.nlm.nih.gov/11303048
Publikováno v:
Europe PubMed Central
Pharmacological studies in vivo and in vitro have suggested the existence of subtypes of the delta opioid receptor termed delta1 and delta2 (delta1 and delta2). The hypothesis of subtypes of delta receptors was further explored by assessing the effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0417ae96363453330b0b08c39bcb7bbc
https://pubmed.ncbi.nlm.nih.gov/8613959
https://pubmed.ncbi.nlm.nih.gov/8613959
Publikováno v:
Europe PubMed Central
Previous studies measuring opioid inhibition of cyclic adenosine monophosphate in SH-SY5Y cells supported the hypothesis that continuous agonist stimulation causes a gradual conversion of the mu opioid receptor to a sensitized or constitutively activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d088b0569fdf90200acdc0e8a0c23208
https://pubmed.ncbi.nlm.nih.gov/8613958
https://pubmed.ncbi.nlm.nih.gov/8613958
Autor:
Edward Bilsky, Sn, Calderon, Wang T, Rn, Bernstein, Davis P, Vj, Hruby, Rw, Mcnutt, Rb, Rothman, Kc, Rice, Porreca F
Publikováno v:
Europe PubMed Central
The present study has investigated the pharmacology of SNC 80, a nonpeptidic ligand proposed to be a selective delta agonist in vitro and in vivo. SNC 80 was potent in producing inhibition of electrically induced contractions of mouse vas deferens, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ea677cc7a43b9da7880b2e968c7a0efd
https://pubmed.ncbi.nlm.nih.gov/7714789
https://pubmed.ncbi.nlm.nih.gov/7714789
Autor:
Pj, Horan, Mattia A, Edward Bilsky, Weber S, Tp, Davis, Hi, Yamamura, Malatynska E, Sm, Appleyard, Slaninova J, Misicka A
Publikováno v:
Europe PubMed Central
The dimeric enkephalin biphalin (Try-D-Ala-Gly-Phe-NH)2 was evaluated in mice using antinociceptive, gastrointestinal and physical dependence paradigms and compared with that of morphine (reference mu agonist) and etorphine (ultrapotent opioid agonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::97e95877a5001baf94423822405fb512
https://pubmed.ncbi.nlm.nih.gov/8389867
https://pubmed.ncbi.nlm.nih.gov/8389867
Autor:
Anne-Cécile Hiebel, Yong Sok Lee, Edward Bilsky, Denise Giuvelis, Jeffrey R. Deschamps, Damon A. Parrish, Mario D. Aceto, Everette L. May, Louis S. Harris, Andrew Coop, Christina M. Dersch, John S. Partilla, Richard B. Rothman, Kejun Cheng, Arthur E. Jacobson, Kenner C. Rice
Publikováno v:
Journal of Medicinal Chemistry; Aug2007, Vol. 50 Issue 16, p3765-3776, 12p
Publikováno v:
Europe PubMed Central
Research in our laboratories involves the development of selective opioid agonists and antagonists as: 1) pharmacological tools to elucidate the mechanisms of opioid antinociception, and 2) potential analgesics that possess therapeutic advantages ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::267c8f708608b4a600f871e3c66e5546
http://europepmc.org/abstract/med/10734164
http://europepmc.org/abstract/med/10734164
Publikováno v:
Europe PubMed Central
This study explored the antinociceptive properties of (+-)-4-[(alpha- R*)-alpha-[(2S*,5R*)-4-allyl-2,5-dimethyl-1-piperazinol]-3-hydroxy benzyl] - N,N-diethyl-benzamide dihydrochloride (BW373U86) a nonpeptidic compound proposed to be a delta opioid a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7b94e0ac7dd5b0b9e3564ad052c3fc10
http://europepmc.org/abstract/med/8246160
http://europepmc.org/abstract/med/8246160