Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Edward Bernton"'
Publikováno v:
Clinical Pharmacology in Drug Development. 3:477-486
PRTX-100 is a highly-purified preparation of staphylococcal protein A (SpA), with immunologic activity in vitro and in animal models of immune-mediated inflammation. Following single-dose healthy volunteer studies of safety and pharmacokinetics (PK),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93a0a344e358a5bbb5dd5b3e262b1e0b
https://doi.org/10.1002/cpdd.116
https://doi.org/10.1002/cpdd.116
Autor:
David Haughey, Edward Bernton, Jim Yan, Charles H. Ballow, Anissa Leh, Kimberly Slentz-Kesler
Publikováno v:
The Journal of Clinical Pharmacology. 53:909-918
A single-dose study was conducted to characterize the safety, pharmacokinetic, immunogenicity, and pharmacodynamic activity of highly purified Staphylococcal protein A (SPA), a native bacterial protein with immune-modulatory activity. Twenty healthy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87a3bd240063f1ba86dd4c0f6290a65f
https://doi.org/10.1002/jcph.119
https://doi.org/10.1002/jcph.119
Autor:
Thomas L. Rudge, Nancy F. Daczkowski, Paulina E. Kaptur, Derek Muse, Robert J. Hopkins, Edward Bernton, Suha Sari, Craig LaForce, Eric Sheldon
Publikováno v:
Vaccine. 31:3051-3058
A new anthrax vaccine that could accelerate the immune response and possibly reduce the number of injections needed for protection would be desirable in a post-exposure setting. This Phase 1 study compared the safety and immunogenicity of 2 IM doses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c65cef699fbe3c08c859dea22bc944e
https://doi.org/10.1016/j.vaccine.2013.04.063
https://doi.org/10.1016/j.vaccine.2013.04.063
Autor:
Boris Ionin, Ronald T. Aimes, Edward Bernton, Gabriel T. Meister, George Atiee, Robert J. Hopkins, Mario H. Skiadopoulos, Eric M. Vela, Nina V. Malkevich, Gary S. Nabors, Virginia Johnson
Publikováno v:
Antimicrobial agents and chemotherapy. 58(7)
Anthrax is an acute infectious disease caused by the spore-forming bacterium Bacillus anthracis . Timely administration of antibiotics approved for the treatment of anthrax disease may prevent associated morbidity and mortality. However, any delay in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8edfe43bdcf98628963668da74ab99f
https://pubmed.ncbi.nlm.nih.gov/24733473
https://pubmed.ncbi.nlm.nih.gov/24733473
Autor:
Edward Bernton, David Haughey
Publikováno v:
Basicclinical pharmacologytoxicology. 115(5)
Three Good Laboratory Practice safety studies were performed with intravenous injections of highly purified staphylococcal protein A (SPA) in cynomolgus monkeys, in support of a clinical development programme utilizing this protein as an immunomodula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6fccc23130b87d7f6ee9ffbf34775ab
https://pubmed.ncbi.nlm.nih.gov/24674306
https://pubmed.ncbi.nlm.nih.gov/24674306
Publikováno v:
Clinical pharmacology in drug development. 3(6)
PRTX-100 is a highly-purified preparation of staphylococcal protein A (SpA), with immunologic activity in vitro and in animal models of immune-mediated inflammation. Following single-dose healthy volunteer studies of safety and pharmacokinetics (PK),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1f8ea1d4bcf38d2c96aa7ae494d19728
https://pubmed.ncbi.nlm.nih.gov/27129122
https://pubmed.ncbi.nlm.nih.gov/27129122
Autor:
Charles, Ballow, Anissa, Leh, Kimberly, Slentz-Kesler, Jim, Yan, David, Haughey, Edward, Bernton
Publikováno v:
Journal of clinical pharmacology. 53(9)
A single-dose study was conducted to characterize the safety, pharmacokinetic, immunogenicity, and pharmacodynamic activity of highly purified Staphylococcal protein A (SPA), a native bacterial protein with immune-modulatory activity. Twenty healthy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aecec334da970aee0ea4646f75dab808
https://pubmed.ncbi.nlm.nih.gov/23832863
https://pubmed.ncbi.nlm.nih.gov/23832863
Publikováno v:
Annals of the New York Academy of Sciences. 774
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32de21e7e08331f0e87fa237dda17188
https://pubmed.ncbi.nlm.nih.gov/8597461
https://pubmed.ncbi.nlm.nih.gov/8597461
Autor:
Edward Bernton, Andrea M. Harris, Diane L. Sweeney, Robert J. Hopkins, Jacob T. Minang, David G. Alleva, Jon R Inglefield, Michael J. Lacy, Janet L. Lathey
Publikováno v:
Vaccine. (50):6847-6854
NuThrax™ (Anthrax Vaccine Adsorbed with CPG 7909 Adjuvant) (AV7909) is in development. Samples obtained in a Phase Ib clinical trial were tested to confirm biomarkers of innate immunity and evaluate effects of CPG 7909 (PF-03512676) on adaptive imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8451afeac445e9fd0fb3ad5718f72d58
Publikováno v:
Gastrointestinal Endoscopy. 28:90-92
Pseudoobstruction of the colon was first described by Ogilvie in 1948 when a laparotomy for an apparent obstruction of the large bowel revealed a massively dilated cecum and ascending colon without the expected obstructing cancer. Instead, an extraco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d1233741cdaf27952ddb4c757ce423b
https://doi.org/10.1016/s0016-5107(82)73008-1
https://doi.org/10.1016/s0016-5107(82)73008-1