Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Edward B Leof"'
Autor:
Aidan J Peterson, Stephen J Murphy, Melinda G Mundt, MaryJane Shimell, Edward B Leof, Michael B O'Connor
Publikováno v:
PLoS Biology, Vol 20, Iss 5, p e3001660 (2022)
In polarized epithelial cells, receptor-ligand interactions can be restricted by different spatial distributions of the 2 interacting components, giving rise to an underappreciated layer of regulatory complexity. We explored whether such regulation o
Externí odkaz:
https://doaj.org/article/cc3cee1f4bca4e6cb80a132153bce699
B7-1 drives TGF-β stimulated pancreatic carcinoma cell migration and expression of EMT target genes.
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0222083 (2019)
B7-1 proteins are routinely expressed on the surface of antigen presenting cells (APC) and within the innate immune system. They function to establish a biologically optimal and dynamic balance between immune activation and inhibition or self-toleran
Externí odkaz:
https://doaj.org/article/c8a249db8ee04f89b327798f3b88dfd6
Autor:
Edward B. Leof, Rod A. Rahimi, Theodore J. Kottom, Maryanne Edens, Claire E. Repellin, Mark C. Wilkes, Mahefatiana Andrianifahanana
Supplementary Figures 1-2 from ERBB Receptor Activation Is Required for Profibrotic Responses to Transforming Growth Factor β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1411f443304b675ea6273b6460aceefb
https://doi.org/10.1158/0008-5472.22384992.v1
https://doi.org/10.1158/0008-5472.22384992.v1
Autor:
Edward B. Leof, Rod A. Rahimi, Theodore J. Kottom, Maryanne Edens, Claire E. Repellin, Mark C. Wilkes, Mahefatiana Andrianifahanana
Supplementary Table 1 from ERBB Receptor Activation Is Required for Profibrotic Responses to Transforming Growth Factor β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::554784f7083309d724f90e136a74f17f
https://doi.org/10.1158/0008-5472.22384986.v1
https://doi.org/10.1158/0008-5472.22384986.v1
Autor:
Malay Choudhury, Kyle J. Schaefbauer, Xueqian Yin, Jeong Han Kang, Edward B. Leof, Andrew H. Limper, Theodore J. Kottom, Bhaskar Roy
Publikováno v:
The FASEB Journal. 34:8920-8940
In the current work we show that the profibrotic actions of TGF-β are mediated, at least in part, through a metabolic maladaptation in glutamine metabolism and how the inhibition of glutaminase 1 (GLS1) reverses pulmonary fibrosis. GLS1 was found to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::841651646f140d706549a50e7cf69f07
https://doi.org/10.1096/fj.202000564r
https://doi.org/10.1096/fj.202000564r
Autor:
Michael H. Bourne, Theodore J. Kottom, Deanne M. Hebrink, Malay Choudhury, Edward B. Leof, Andrew H. Limper
Publikováno v:
Cells, Vol 10, Iss 3502, p 3502 (2021)
Cells
Cells; Volume 10; Issue 12; Pages: 3502
Cells
Cells; Volume 10; Issue 12; Pages: 3502
Idiopathic pulmonary fibrosis (IPF) remains an intractably fatal disorder, despite the recent advent of anti-fibrotic medication. Successful treatment of IPF, like many chronic diseases, may benefit from the concurrent use of multiple agents that exh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ceeea63dd5475a3b6b77a03ef8cc8ac
https://www.mdpi.com/2073-4409/10/12/3502
https://www.mdpi.com/2073-4409/10/12/3502
Autor:
Melinda G. Mundt, Aidan J. Peterson, MaryJane Shimell, Edward B. Leof, Stephen J. Murphy, Michael B. O'Connor
Publikováno v:
SSRN Electronic Journal.
In polarized epithelial cells, receptor-ligand interactions can be restricted by different spatial distributions of the two interacting components, giving rise to an underappreciated layer of regulatory complexity. We explored whether such regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5994e0166dd70cac1b4da78d94d7666a
https://doi.org/10.2139/ssrn.3817757
https://doi.org/10.2139/ssrn.3817757
Autor:
MaryJane Shimell, Michael B. O'Connor, Stephen J. Murphy, Edward B. Leof, Melinda G. Mundt, Aidan J. Peterson
In polarized epithelial cells, receptor-ligand interactions can be restricted by different spatial distributions of the two interacting components, giving rise to an underappreciated layer of regulatory complexity. We explored whether such regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8ed6ae50000481528aa8f5a71bfa1b6
https://doi.org/10.1101/2020.10.05.327056
https://doi.org/10.1101/2020.10.05.327056
Autor:
Xueqian Yin, Andrew H. Limper, Jeong Han Kang, Edward B. Leof, Mahefatiana Andrianifahanana, Malay Choudhury, Danielle M. Hernandez
Publikováno v:
FASEB J
Pathogenic fibrotic diseases, including Idiopathic Pulmonary Fibrosis (IPF), have some of the worst prognoses and affect millions of people worldwide. With unclear etiology and minimally effective therapies, two-thirds of IPF patients die within 2-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e6e8d3c71dd1f73317acfd81433cd7
https://europepmc.org/articles/PMC7136152/
https://europepmc.org/articles/PMC7136152/
Autor:
Mahefatiana Andrianifahanana, Mi-Yeon Jung, Edward B. Leof, Kyle J. Schaefbauer, Xueqian Yin, Danielle M. Hernandez, Jeong Han Kang, Malay Choudhury
Publikováno v:
Science Signaling. 12
Metabolic dysregulation in fibroblasts is implicated in the profibrotic actions of transforming growth factor-β (TGF-β). Here, we present evidence that hexokinase 2 (HK2) is important for mediating the fibroproliferative activity of TGF-β both in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be4d0e4eeca3251c4fafe7f252989621
https://doi.org/10.1126/scisignal.aax4067
https://doi.org/10.1126/scisignal.aax4067