Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Edward B Kirsten"'
Autor:
Edward B. Kirsten, Walter M. St. John
Publikováno v:
Journal of Pharmacological Methods. 1:263-268
A technique is described which details simple and rapid surgical procedures for an acute midcollicular decerebration in the adult cat. This decerebration procedure includes a bilateral ligation of the external carotid arteries and is performed under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ca12658777bf4a86850b2bbb8cd0594
https://doi.org/10.1016/0160-5402(78)90057-8
https://doi.org/10.1016/0160-5402(78)90057-8
Publikováno v:
Clinical Pharmacology and Therapeutics. 45:535-541
Propafenone, a class IC antiarrhythmic agent, is metabolized into two active metabolites: 5-hydroxypropafenone (5-OHP) and JV-depropylpropafenone (NDPP). In a placebo-controlled, double-blind study, we examined trough plasma concentrations of propafe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::362e62ec206a6052aaa64c204e5890fc
https://doi.org/10.1038/clpt.1989.69
https://doi.org/10.1038/clpt.1989.69
Publikováno v:
Clinical Pharmacology and Therapeutics. 42:305-311
The effect of propafenone on the pharmacokinetics and pharmacologic effects of warfarin was studied in healthy normal male volunteer subjects. Each drug was administered alone for 1 week followed by a combined administration for 1 additional week. Bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7289bab2c27ab485f9b82cd732654c6
https://doi.org/10.1038/clpt.1987.152
https://doi.org/10.1038/clpt.1987.152
Publikováno v:
The Journal of Clinical Pharmacology. 28:619-624
The pharmacokinetics and pharmacodynamics of the extensively metabolized antiarrhythmic agent propafenone were assessed alone and during concomitant administration of cimetidine. Twelve healthy subjects were given successively the following treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f147b250b2754a801b44b89215d665f
https://doi.org/10.1002/j.1552-4604.1988.tb03185.x
https://doi.org/10.1002/j.1552-4604.1988.tb03185.x
Autor:
Sandra R. Harapat, Edward B Kirsten, Robert E. Kates, Janice B. Schwartz, Deborah L. Keefe, Donald C. Harrison
Publikováno v:
Clinical Pharmacology and Therapeutics. 30:44-51
Verapamil disposition was studied in 12 patients with chronic and fibrillation. After an intravenous bolus of 15 mg plasma concentration was determined and the data fit in a three-compartment model. Model independent parameters were calculated and va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046f0de9631650a2cf3f3f355b3ff452
https://doi.org/10.1038/clpt.1981.125
https://doi.org/10.1038/clpt.1981.125
Autor:
Edward B. Kirsten, Eugene P. Schoener
Publikováno v:
European Journal of Pharmacology. 19:165-170
The response of single, motion-sensitive neurons in the vestibular nuclei to systemic administration of perphenazine was studied in 18 cats. 14 of the 22 units examined showed depression of their activity. The extent of depression for a given dose va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc8bb6a4a9c67727f2f6daea4246964
https://doi.org/10.1016/0014-2999(72)90005-2
https://doi.org/10.1016/0014-2999(72)90005-2
Publikováno v:
European journal of pharmacology. 41(1)
The activity of single neurons in the vestibular neuronal complex of midcollicular decerebrate, decerebellectomized cats were recorded and their responsiveness to iontophoretically applied histamine and other agents determined. The majority of the ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dab90656e8eafd5cad33e6e7c32e8a4
https://pubmed.ncbi.nlm.nih.gov/12984
https://pubmed.ncbi.nlm.nih.gov/12984
Autor:
Edward B. Kirsten
Publikováno v:
Brain research. 97(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8982d1255d8b47c02d7d683baa9dc15e
https://pubmed.ncbi.nlm.nih.gov/1175052
https://pubmed.ncbi.nlm.nih.gov/1175052
Publikováno v:
British journal of pharmacology. 63(2)
1 Cats with midcollicular decerebration were vagotomized, paralyzed and artificially ventilated. Phrenic nerve activity was recorded as an index of central respiratory rhythm. Medullary respiratory neurones and non-respiratory cells located in approx
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91dd71dae814cdd0786e1d47a34e9770
https://pubmed.ncbi.nlm.nih.gov/27271
https://pubmed.ncbi.nlm.nih.gov/27271
Publikováno v:
Journal of pharmaceutical sciences. 76(6)
Twenty-four healthy male subjects were administered 300 mg of propafenone every 8 h for 6 d in each of two phases that were separated by 2 d. Plasma samples were collected during the approach to steady state for each phase, and plasma and saliva samp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c686a92bfcee526cc922b40f669e8999
https://pubmed.ncbi.nlm.nih.gov/3625486
https://pubmed.ncbi.nlm.nih.gov/3625486