Zobrazeno 1 - 10 of 152 pro vyhledávání: '"Edward B, Brown"'
1
Akademický článek
Intratumoral heterogeneity of second-harmonic generation scattering from tumor collagen and its effects on metastatic risk prediction
Autor: Danielle E. Desa, Robert L. Strawderman, Wencheng Wu, Robert L. Hill, Marcel Smid, J. W. M. Martens, Bradley M. Turner, Edward B. Brown
Publikováno v: BMC Cancer, Vol 20, Iss 1, Pp 1-14 (2020)
Abstract Background Metastases are the leading cause of breast cancer-related deaths. The tumor microenvironment impacts cancer progression and metastatic ability. Fibrillar collagen, a major extracellular matrix component, can be studied using the l
Externí odkaz: https://doaj.org/article/fdbdba99c78b4fe0a6cbb731ab32a392
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2
Akademický článek
Chronic Stress Exposure Suppresses Mammary Tumor Growth and Reduces Circulating Exosome TGF-β Content via β-Adrenergic Receptor Signaling in MMTV-PyMT Mice
Autor: Ryan P Dawes, Kathleen A Burke, Daniel K Byun, Zhou Xu, Petr Stastka, Leland Chan, Edward B Brown, Kelley S Madden
Publikováno v: Breast Cancer: Basic and Clinical Research, Vol 14 (2020)
Preclinical models of breast cancer have established mechanistic links between psychological stress and cancer progression. However, epidemiological evidence linking stress and cancer is equivocal. We tested the impact of stress exposure in female mi
Externí odkaz: https://doaj.org/article/d4139f1831e34ef887c0debdfec2eac0
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3
Multiphoton Phosphorescence Quenching Microscopy Reveals Kinetics of Tumor Oxygenation during Antiangiogenesis and Angiotensin Signaling Inhibition
Autor: John D. Martin, Ryan M. Lanning, Vikash P. Chauhan, Margaret R. Martin, Ahmed S. Mousa, Walid S. Kamoun, Hee-Sun Han, Hang Lee, Triantafyllos Stylianopoulos, Moungi G. Bawendi, Dan G. Duda, Edward B. Brown, Timothy P. Padera, Dai Fukumura, Rakesh K. Jain
Publikováno v: Clinical Cancer Research. 28:3076-3090
Purpose: The abnormal function of tumor blood vessels causes tissue hypoxia, promoting disease progression and treatment resistance. Although tumor microenvironment normalization strategies can alleviate hypoxia globally, how local oxygen levels chan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a4a5363475591f35309b16beae72815
https://doi.org/10.1158/1078-0432.ccr-22-0486
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4
Data from The Antidepressant Desipramine and α2-Adrenergic Receptor Activation Promote Breast Tumor Progression in Association with Altered Collagen Structure
Autor: Kelley S. Madden, Edward B. Brown, Ryan P. Dawes, Kathleen A. Burke, Mercedes J. Szpunar
Emotional stress activates the sympathetic nervous system (SNS) and release of the neurotransmitter norepinephrine to promote breast tumor pathogenesis. We demonstrate here that the metastatic mammary adenocarcinoma cell line 4T1 does not express fun
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15edaa5d966ddf1dc7f756b210de1eb8
https://doi.org/10.1158/1940-6207.c.6544250
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5
Data Supplement from The Antidepressant Desipramine and α2-Adrenergic Receptor Activation Promote Breast Tumor Progression in Association with Altered Collagen Structure
Autor: Kelley S. Madden, Edward B. Brown, Ryan P. Dawes, Kathleen A. Burke, Mercedes J. Szpunar
Supplemental Fig. S1. 4T1 Cells Do Not Express Functional a2-AR. High dose DEX-induced effects on 4T1 (A) proliferation and (B) VEGF production in vitro are not blocked by the a2-AR antagonist yohimbine (YOH). (C) The alpha2-AR agonists clonidine (CL
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ec59b7b81aad27dfac1c7244719e393
https://doi.org/10.1158/1940-6207.22524437.v1
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8
Data from Differential Transplantability of Tumor-Associated Stromal Cells
Autor: Rakesh K. Jain, Brian Seed, Peigen Huang, Edward B. Brown, Michael F. Booth, Lance L. Munn, Dai Fukumura, Dan G. Duda
At the time of transplantation, tumor fragments contain “passenger” cells: endothelial cells and other stromal cells from the original host. Here, we investigated the fate of genetically labeled endothelial and nonendothelial stromal cells after
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fa55b2aa986a51aac558511d0dfa6d1
https://doi.org/10.1158/0008-5472.c.6493647.v1
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9
Matching an immersion medium's refractive index to a cell's cytosol isolates organelle scattering
Autor: Kaitlin J. Dunn, Tresa M. Elias, Edward B. Brown, Andrew J. Berger
Publikováno v: Biomed Opt Express
Angularly-resolved light scattering has been proven to be an early detector of subtle changes in organelle size due to its sensitivity to scatterer size and refractive index contrast. However, for cells immersed in media with a refractive index close
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::416012fae944549966e14489d43c21ea
https://pubmed.ncbi.nlm.nih.gov/36032574
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10
Second-Harmonic Generation Imaging Reveals Changes in Breast Tumor Collagen Induced by Neoadjuvant Chemotherapy
Autor: Danielle E. Desa, Wencheng Wu, Robert M. Brown, Edward B. Brown, Robert L. Hill, Bradley M. Turner
Publikováno v: Cancers; Volume 14; Issue 4; Pages: 857
Breast cancer is the most common invasive cancer in women, with most deaths attributed to metastases. Neoadjuvant chemotherapy (NACT) may be prescribed prior to surgical removal of the tumor for subsets of breast cancer patients but can have diverse
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a97d16119ccdf56f5a75ee2dfc3e0f42
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