Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Edward Aig"'
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ChemInform Abstract: 2,4-DIAMINO-5-BENZYLPYRIMIDINES AS ANTIBACTERIAL AGENTS. 4. 6-SUBSTITUTED TRIMETHOPRIM DERIVATIVES FROM PHENOLIC MANNICH INTERMEDIATES. APPLICATION TO THE SYNTHESIS OF TRIMETHOPRIM AND 3,5-DIALKYLBENZYL ANALOGS
Autor: Kenneth Lane, Edward Aig, Barbara S. Rauckman, Barbara Roth
Publikováno v: Chemischer Informationsdienst. 11
The preparation of a wide variety of 6-substituted trimethoprim analogues was readily accomplished by the reaction of 2,4-diamino-6-substituted-pyrimidines with 2,6-dimethoxy-4-[(N,N-dimethylamino)methyl]phenol at 120--160 degrees C. The less reactiv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3edf5e5ba4ea30b52e58b78282f9eed5
https://doi.org/10.1002/chin.198038234
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3
2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 4. 6-Substituted trimethoprim derivatives from phenolic Mannich intermediates. Application to the synthesis of trimethoprim and 3,5-dialkylbenzyl analogues
Autor: Kenneth Lane, Edward Aig, Barbara S. Rauckman, Barbara Roth
Publikováno v: Journal of medicinal chemistry. 23(5)
The preparation of a wide variety of 6-substituted trimethoprim analogues was readily accomplished by the reaction of 2,4-diamino-6-substituted-pyrimidines with 2,6-dimethoxy-4-[(N,N-dimethylamino)methyl]phenol at 120--160 degrees C. The less reactiv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f79c550e67485e97da5ddae44d43b5
https://pubmed.ncbi.nlm.nih.gov/6991695
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4
2,4-diamino-5-benzylpyrimidines and analogues as antibacterial agents. 6. A one-step synthesis of new trimethoprim derivatives and activity analysis by molecular modeling
Autor: Barbara Roth, Edward Aig, Alexander Stuart, Thomas Paterson
Publikováno v: Journal of medicinal chemistry. 26(5)
A new route to 2,4-diamino-5-(4-hydroxybenzyl)pyrimidines has been developed that involves the condensation of 2,4-diamino-5-(hydroxymethyl)pyrimidine with phenols in acidic medium. The use of phenol and its 2,6-dialkyl derivatives produces 5-(4-hydr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05b8dce8a7889207746e36c4ee85cde4
https://pubmed.ncbi.nlm.nih.gov/6341588
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5
2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 8. The 3,4,5-triethyl isostere of trimethoprim. A study of specificity
Autor: Edward Aig, Barbara Roth
Publikováno v: Journal of medicinal chemistry. 30(11)
3,4,5-Triethylacetophenone was synthesized in 60% yield by a Friedel-Crafts reaction from 4-ethylacetophenone and converted to 2,4-diamino-5-(3,4,5-triethylbenzyl)pyrimidine (2), a trimethoprim (1) isostere, by standard techniques. This compound is m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75c138cc39daeef073665cf79ae192fd
https://pubmed.ncbi.nlm.nih.gov/3312605
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6
2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 5. 3',5'-Dimethoxy-4'-substituted-benzyl analogues of trimethoprim
Autor: Robert Ferone, Justina Z. Strelitz, Barbara Roth, Edward Aig, S. R. M. Bushby, Carl W. Sigel, Arthur P. Phillips, Barbara S. Rauckman
Publikováno v: Journal of medicinal chemistry. 24(8)
Forty trimethoprim analogues in which the para substituent in the benzene ring was varied were prepared for antibacterial evaluation. All were very potent inhibitors of Escherichia coli dihydrofolate reductase. The similarity of their inhibitory acti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4666722b9d0fc388d2de0b00130bd857
https://pubmed.ncbi.nlm.nih.gov/7035668
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