Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Edward A. Wydysh"'
Autor:
Leslie E. Landree, Francis P. Kuhajda, Edward A. Wydysh, Khadija Daniels, Yajun Tu, Wan Fang Han, Susan M. Medghalchi, Jonathan M. Peterson, Craig A. Townsend, Kody Wong, Gabriele V. Ronnett, Susan Aja, Rajaa El Meskini
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 301:R116-R130
Storage of excess calories as triglycerides is central to obesity and its associated disorders. Glycerol-3-phosphate acyltransferases (GPATs) catalyze the initial step in acylglyceride syntheses, including triglyceride synthesis. We utilized a novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d90a0025cb30411f85b3328e144809b
https://doi.org/10.1152/ajpregu.00147.2011
https://doi.org/10.1152/ajpregu.00147.2011
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:6470-6479
Glycerol 3-phosphate acyltransferase (GPAT) isozymes are central control points for fat synthesis in mammals. Development of inhibitors of these membrane-bound enzymes could lead to an effective treatment for obesity, but is thwarted by an absence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d0ffd60099e6fc16be233cdbc186443
https://doi.org/10.1016/j.bmc.2010.06.091
https://doi.org/10.1016/j.bmc.2010.06.091
Publikováno v:
Journal of medicinal chemistry. 52(10)
The incidence of obesity and other diseases associated with an increased triacylglycerol mass is growing rapidly, particularly in the United States. Glycerol 3-phosphate acyltransferase (GPAT) catalyzes the rate-limiting step of glycerolipid biosynth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ccbe398cda8102f6e3eed967c7b62e7
https://pubmed.ncbi.nlm.nih.gov/19388675
https://pubmed.ncbi.nlm.nih.gov/19388675
Autor:
Craig A. Townsend, Susan M. Medghalchi, Aravinda Vadlamudi, Victor K. Outlaw, Edward A. Wydysh
Publikováno v:
MedChemComm. 5:826
Despite a rising demand for anti-obesity therapeutics, few effective pharmacological options are clinically available that target the synthesis and accumulation of body fat. Moderate inhibition of mammalian glycerol-3-phosphate acyltransferase (GPAT)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e208480ad3bf2328c1582204989d8df2
https://doi.org/10.1039/c4md00126e
https://doi.org/10.1039/c4md00126e
Publikováno v:
Journal of Medicinal Chemistry; May2009, Vol. 52 Issue 10, p3317-3327, 11p