Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Edward A. Skolnik"'
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0211670 (2019)
Tolvaptan is the only drug approved to slow cyst growth and preserve kidney function in patients with autosomal dominant polycystic kidney disease (ADPKD). However, its limited efficacy combined with significant side effects underscores the need to i
Externí odkaz:
https://doaj.org/article/253b067a651e4b7d8dcfb027dd1b24a5
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183474 (2017)
Cross linking of the IgE receptor (FcεRI) on mast cells plays a critical role in IgE-dependent allergy including allergic rhinitis, asthma, anaphylaxis, and delayed type hypersensitivity reactions. The Ca2+ activated K+ channel, KCa3.1, plays a crit
Externí odkaz:
https://doaj.org/article/5b6e69f1bc1b48e8be25ac8f7178f12e
Autor:
Shekhar Srivastava, Saswati Panda, Zhai Li, Stephen R Fuhs, Tony Hunter, Dennis J Thiele, Stevan R Hubbard, Edward Y Skolnik
Publikováno v:
eLife, Vol 5 (2016)
KCa2.1, KCa2.2, KCa2.3 and KCa3.1 constitute a family of mammalian small- to intermediate-conductance potassium channels that are activated by calcium-calmodulin. KCa3.1 is unique among these four channels in that activation requires, in addition to
Externí odkaz:
https://doaj.org/article/5b5442ef43d443148613484addd7e8b0
Autor:
Chonghong Li, Ying Sun, Edward Y. Skolnik, Li Bao, Zhai Li, Irfana Soomro, Shekhar Srivastava, William A. Coetzee, Jianhui Wang, Charles A. Stanley
Publikováno v:
Diabetes. 67:849-860
Protein histidine phosphatase 1 (PHPT-1) is an evolutionarily conserved 14-kDa protein that dephosphorylates phosphohistidine. PHPT-1−/− mice were generated to gain insight into the role of PHPT-1 and histidine phosphorylation/dephosphorylation i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5dee5a030fa895c217366d75ccca65e6
https://doi.org/10.2337/db17-1433
https://doi.org/10.2337/db17-1433
Autor:
Katharina Spiger, Ali El-Armouche, Benjamin Meder, András Varró, Edward Y. Skolnik, Niels Voigt, Viacheslav O. Nikolaev, Hugo A. Katus, Nadine M. Wolf, Lorenz H. Lehmann, Christiane Vettel, Marion Müller, Hans-Jörg Hippe, Stefan Neef, Christina M. Würtz, Johannes Backs, Susanne Lutz, Thomas Wieland, István Baczkó, Dobromir Dobrev, Jordi Heijman, Marina Schäfer, Issam Abu-Taha
Publikováno v:
Circulation. 135:881-897
Background: Chronic heart failure (HF) is associated with altered signal transduction via β-adrenoceptors and G proteins and with reduced cAMP formation. Nucleoside diphosphate kinases (NDPKs) are enriched at the plasma membrane of patients with end
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f958542d1917a9232ff8f903a3a8abd1
https://doi.org/10.1161/circulationaha.116.022852
https://doi.org/10.1161/circulationaha.116.022852
Autor:
Edward Y. Skolnik, Shekhar Srivastava, Inbar Azoulay-Alfaguter, Marianne Strazza, Alan V. Smrcka, Adam Mor, Michael Peled
Publikováno v:
Proceedings of the National Academy of Sciences. 114:2693-2698
Regulation of integrins is critical for lymphocyte adhesion to endothelium and migration throughout the body. Inside-out signaling to integrins is mediated by the small GTPase Ras-proximate-1 (Rap1). Using an RNA-mediated interference screen, we iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a9f2043bc9148f4028ade027703c1f
https://doi.org/10.1073/pnas.1612900114
https://doi.org/10.1073/pnas.1612900114
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 7, p e0211670 (2019)
PLoS ONE, Vol 14, Iss 7, p e0211670 (2019)
Tolvaptan is the only drug approved to slow cyst growth and preserve kidney function in patients with autosomal dominant polycystic kidney disease (ADPKD). However, its limited efficacy combined with significant side effects underscores the need to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef1d000deeede2e27a06e3e6f47576f6
https://pubmed.ncbi.nlm.nih.gov/31260458
https://pubmed.ncbi.nlm.nih.gov/31260458
Autor:
Edward Y. Skolnik, Tony Hunter, Shekhar Srivastava, Stephen Rush Fuhs, Zhai Li, Saswati Panda, Martin Vaeth
Publikováno v:
Molecular Cell. 63:457-469
Whereas phosphorylation of serine, threonine, and tyrosine is exceedingly well characterized, the role of histidine phosphorylation in mammalian signaling is largely unexplored. Here we show that phosphoglycerate mutase family 5 (PGAM5) functions as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::482f3284592a4c177673adbf2e805690
https://doi.org/10.1016/j.molcel.2016.06.021
https://doi.org/10.1016/j.molcel.2016.06.021
Autor:
Edward Y. Skolnik, William C. Huang, Pari V. Pandharipande, Debra A. Gervais, R. Scott Braithwaite, Stella K. Kang
Publikováno v:
American Journal of Roentgenology. 207:344-353
The purpose of this article is to compare the effectiveness of a treatment algorithm for small renal tumors incorporating the nephrometry score, a renal tumor anatomy scoring system developed by urologists, with the current standard of uniformly reco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6adaa91ca557e133b5eda159524fff8
https://doi.org/10.2214/ajr.15.15823
https://doi.org/10.2214/ajr.15.15823
Autor:
Edward Y. Skolnik, Qiang Sun, Yi Qiu, Thomas Wieland, Robert Lukowski, Martin Borggrefe, Yu-Xi Feng, Dobromir Dobrev, Xiaobo Zhou, Michael Korth, Peter Ruth, Katharina Spiger, Zhai Li
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 35:1852-1861
Objective— Vascular smooth muscle cells (VSMC) proliferation is a hallmark of atherosclerosis and vascular restenosis. The intermediate conductance Ca 2+ -activated K + (SK4) channel is required for pathological VSMC proliferation. In T lymphocytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a09b4163c3fae1b8ddee87dacaa85f
https://doi.org/10.1161/atvbaha.115.305881
https://doi.org/10.1161/atvbaha.115.305881