Výsledky vyhledávání - "Edward A. Nodiff"

In search of next generation antimalarials

Autor: Sankar Chatterjee, Edward A. Nodiff, Keiichi Tanabe

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 24:4106-4109

Compounds 7 – 10 displayed potency without any apparent toxicity, in animal models of both relapsing and non-relapsing forms of malaria offering hope of a single molecule that can cure both relapsing and non relapsing forms of malaria.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fa0ee533ac11885bad662687e746435
https://doi.org/10.1016/j.bmcl.2014.07.059

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1 Antimalarial Activity of the 8-Aminoquinolines

Autor: Hikmat A. Musallam, Edward A. Nodiff, Sankar Chatterjee

Publikováno v: Progress in Medicinal Chemistry ISBN: 9780444812759

Publisher Summary This chapter describes the evolution of an extremely promising series of new, broad-spectrum, antimalarial 8-aminoquinolines. The new drugs are unique in their dual efficacy against the blood and tissue forms of the disease. Malaria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3f52fba72b31b7c00744f3f47f3cf61
https://doi.org/10.1016/s0079-6468(08)70362-x

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The Synthesis of Potential Antiparasitic Drugs

Autor: Sankar Chatterjee, Edward A. Nodiff, Keiichi Tanabe

During the period from 1 April 1988 - 31 March 1990, we submitted to WRAIR 23 Target compounds (Table I) and 26 intermediates (Table (II). In earlier work, we prepared a series of primaquines with a methyl group at position 4 and a phenylalkoxy group

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7e18b6d9fe81e2d439973a801f5df11
https://doi.org/10.21236/adb145561

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Modifications of primaquine as antimalarials. 2. 5-Phenylthio and 5-anilino derivatives of primaquine

Autor: Keiichi Tanabe, E. H. Chen, Andrew J. Saggiomo, B. L. Verma, Edward A. Nodiff

Publikováno v: Journal of Medicinal Chemistry. 21:133-136

A number of 5-phenylthio and 5-anilino derivatives of primaquine have been prepared which are less toxic but less active than primaquine itself in murine and monkey antimalarial screens. It is apparent that the toxicity of primaquine can be diminishe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e98258287c3eb475b14d5c9b1a2ae62
https://doi.org/10.1021/jm00199a028

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Synthesis of possible metabolites of chlorpromazine. I. 7-hydroxy derivatives of chlorpromazine, nor1-chlorpromazine and nor2-chlorpromazine

Autor: Edward A. Nodiff, Martin Hausman, Sansei Nishibe, Albert A. Manian, Shuichiro Ina, Tetsuya Kohno, Takanori Hayazaki, Noriichi Oda

Publikováno v: Journal of Heterocyclic Chemistry. 4:239-245

The title compounds and various derivatives have been prepared as analytical standards for the identification of chlorpromazine metabolites in biological materials. Additional evidence is presented for the existence of a halogen-induced Smiles rearra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90ef6c10832c439127d14a00a4690d10
https://doi.org/10.1002/jhet.5570040212

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