Zobrazeno 1 - 10
of 732
pro vyhledávání: '"Edward A. Harris"'
Autor:
Xiao Cheng, Vijaya Bhaskar Baki, Matthew Moran, Baolong Liu, Jiujiu Yu, Miaoyun Zhao, Qingsheng Li, Jean-Jack Riethoven, Channabasavaiah B. Gurumurth, Edward N. Harris, Xinghui Sun
Publikováno v:
Molecular Metabolism, Vol 86, Iss , Pp 101977- (2024)
Objective: The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) continues to rise with the increasing obesity epidemic. Rezdiffra as an activator of a thyroid hormone receptor-beta is the only Food and Drug Administratio
Externí odkaz:
https://doaj.org/article/d17136cbcd9146458760bd3e5f1829c2
Publikováno v:
Cells, Vol 13, Iss 18, p 1590 (2024)
Lipopolysaccharide (LPS) in blood circulation causes endotoxemia and is linked to various disease conditions. Current treatments focus on preventing LPS from interacting with its receptor Toll-like receptor 4 (TLR4) and reducing inflammation. However
Externí odkaz:
https://doaj.org/article/309ed9d291244eda9299947c3a4a4d48
Autor:
Ekta Pandey, Edward N. Harris
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 430-443 (2023)
Non-DNA-binding Stabilin-2/HARE receptors expressed on liver sinusoidal endothelial cells specifically bind to and internalize several classes of phosphorothioate antisense oligonucleotides (PS-ASOs). After Stabilin-mediated uptake, PS-ASOs are traff
Externí odkaz:
https://doaj.org/article/34962db0b3d4445bb1ec996f342af8fe
Autor:
Henry Wade, Kaichao Pan, Qihua Duan, Szczepan Kaluzny, Ekta Pandey, Linda Fatumoju, Viswanathan Saraswathi, Rongxue Wu, Edward N. Harris, Qiaozhu Su
Publikováno v:
Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-17 (2023)
Abstract Background The intestinal epithelial barrier is the interface for interaction between gut microbiota and host metabolic systems. Akkermansia muciniphila (A. muciniphila) is a key player in the colonic microbiota that resides in the mucus lay
Externí odkaz:
https://doaj.org/article/416e58378b1046bdbd7212e2c526c788
Autor:
Fraser Brims, Nick de Klerk, Peter Franklin, Bill Musk, Conor Murray, Brendan Adler, Chellan Kumarasamy, Edward JA Harris, Amie Ringuet
Publikováno v:
BMJ Open Respiratory Research, Vol 9, Iss 1 (2022)
Introduction Deliberate exposure to medical ionising radiation should be as low as reasonably practicable but the reduction of radiation from CT should be balanced against diagnostic image quality. The ability of ultra-low-dose CT (uLDCT: similar rad
Externí odkaz:
https://doaj.org/article/60b86e11355445a1804a9248b7c46837
Autor:
Yukako Kayashima, Connor A. Clanton, Amanda M. Lewis, Xinghui Sun, Sylvia Hiller, Phillip Huynh, Jennifer Wilder, John Hagaman, Feng Li, Nobuyo Maeda-Smithies, Edward N. Harris
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
We have previously identified a novel atherosclerosis quantitative trait locus (QTL), Arch atherosclerosis 5 (Aath5), on mouse chromosome 10 by three-way QTL analyses between Apoe−/− mice on a DBA/2J, 129S6 and C57BL/6J background. The DBA/2J hap
Externí odkaz:
https://doaj.org/article/7ac6ecf8ea5941d8b46522da540bffa9
Autor:
Fatima Cabral, Mustafa Al-Rahem, John Skaggs, Thushara A. Thomas, Naresh Kumar, Qian Wu, Paolo Fadda, Lianbo Yu, John M. Robinson, Jonghan Kim, Ekta Pandey, Xinghui Sun, Wael N. Jarjour, Murugesan V.S. Rajaram, Edward N. Harris, Latha P. Ganesan
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103337- (2021)
Summary: Lipopolysaccharides (LPSs) cause lethal endotoxemia if not rapidly cleared from blood circulation. Liver sinusoidal endothelial cells (LSEC) systemically clear LPS by unknown mechanisms. We discovered that LPS clearance through LSEC involves
Externí odkaz:
https://doaj.org/article/209b703b99394a00aadccb8cd283ebee
Autor:
Seung-Hyun Ro, Julianne Fay, Cesar I. Cyuzuzo, Yura Jang, Naeun Lee, Hyun-Seob Song, Edward N. Harris
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Proper timely management of various external and internal stresses is critical for metabolic and redox homeostasis in mammals. In particular, dysregulation of mechanistic target of rapamycin complex (mTORC) triggered from metabolic stress and accumul
Externí odkaz:
https://doaj.org/article/47022f999d9c4e3cb47e6f0a3a3230dd
Autor:
Viswanathan Saraswathi, Narendra Kumar, Weilun Ai, Thiyagarajan Gopal, Saumya Bhatt, Edward N. Harris, Geoffrey A. Talmon, Cyrus V. Desouza
Publikováno v:
Biomolecules, Vol 12, Iss 6, p 739 (2022)
Saturated fatty acids (SFAs) are considered to be detrimental to human health. One of the SFAs, myristic acid (MA), is known to exert a hypercholesterolemic effect in mice as well as humans. However, its effects on altering adipose tissue (AT) inflam
Externí odkaz:
https://doaj.org/article/d1597676fbf74b3490c4edfb052bedad
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Liver sinusoidal endothelial cells (LSECs) are the most abundant non-parenchymal cells lining the sinusoidal capillaries of the hepatic system. LSECs are characterized with numerous fenestrae and lack basement membrane as well as a diaphragm. These u
Externí odkaz:
https://doaj.org/article/6b3e7bc076364ba6a1e8d1faa0ce02e1