Gene Electrotransfer via Conductivity‐Clamped Electric Field Focusing Pivots Sensori‐Motor DNA Therapeutics: 'A Spoonful of Sugar Helps the Medicine Go Down'

Autor: Jeremy L. Pinyon, Georg vonJonquieres, Edward N. Crawford, Amr Al Abed, John M. Power, Matthias Klugmann, Cherylea J. Browne, David M. Housley, Andrew K. Wise, James B. Fallon, Robert K. Shepherd, John Y. Lin, Catherine McMahon, David McAlpine, Catherine S. Birman, Waikong Lai, Ya Lang Enke, Paul M. Carter, James F. Patrick, Robert D. Gay, Corinne Marie, Daniel Scherman, Nigel H. Lovell, Gary D. Housley

Publikováno v: Advanced Science, Vol 11, Iss 30, Pp n/a-n/a (2024)

Abstract Viral vectors and lipofection‐based gene therapies have dispersion‐dependent transduction/transfection profiles that thwart precise targeting. The study describes the development of focused close‐field gene electrotransfer (GET) techno

Externí odkaz: https://doaj.org/article/1f120ece41dd42df991a8e5de27489c2

Effects of Climate and Atmospheric Nitrogen Deposition on Early to Mid-Term Stage Litter Decomposition Across Biomes

Autor: TaeOh Kwon, Hideaki Shibata, Sebastian Kepfer-Rojas, Inger K. Schmidt, Klaus S. Larsen, Claus Beier, Björn Berg, Kris Verheyen, Jean-Francois Lamarque, Frank Hagedorn, Nico Eisenhauer, Ika Djukic, TeaComposition Network, Inger Kappel Schmidt, Klaus Steenberg Larsen, Jean Francois Lamarque, Adriano Caliman, Alain Paquette, Alba Gutiérrez-Girón, Alessandro Petraglia, Algirdas Augustaitis, Amélie Saillard, Ana Carolina Ruiz-Fernández, Ana I. Sousa, Ana I. Lillebø, Anderson da Rocha Gripp, Andrea Lamprecht, Andreas Bohner, André-Jean Francez, Andrey Malyshev, Andrijana Andrić, Angela Stanisci, Anita Zolles, Anna Avila, Anna-Maria Virkkala, Anne Probst, Annie Ouin, Anzar A. Khuroo, Arne Verstraeten, Artur Stefanski, Aurora Gaxiola, Bart Muys, Beatriz Gozalo, Bernd Ahrends, Bo Yang, Brigitta Erschbamer, Carmen Eugenia Rodríguez Ortíz, Casper T. Christiansen, Céline Meredieu, Cendrine Mony, Charles Nock, Chiao-Ping Wang, Christel Baum, Christian Rixen, Christine Delire, Christophe Piscart, Christopher Andrews, Corinna Rebmann, Cristina Branquinho, Dick Jan, Dirk Wundram, Dušanka Vujanović, E. Carol Adair, Eduardo Ordóñez-Regil, Edward R. Crawford, Elena F. Tropina, Elisabeth Hornung, Elli Groner, Eric Lucot, Esperança Gacia, Esther Lévesque, Evanilde Benedito, Evgeny A. Davydov, Fábio Padilha Bolzan, Fernando T. Maestre, Florence Maunoury-Danger, Florian Kitz, Florian Hofhansl, Flurin Sutter, Francisco de Almeida Lobo, Franco Leadro Souza, Franz Zehetner, Fulgence Kouamé Koffi, Georg Wohlfahrt, Giacomo Certini, Gisele Daiane Pinha, Grizelle González, Guylaine Canut, Harald Pauli, Héctor A. Bahamonde, Heike Feldhaar, Heinke Jäger, Helena Cristina Serrano, Hélène Verheyden, Helge Bruelheide, Henning Meesenburg, Hermann Jungkunst, Hervé Jactel, Hiroko Kurokawa, Ian Yesilonis, Inara Melece, Inge van Halder, Inmaculada García Quirós, István Fekete, Ivika Ostonen, Jana Borovská, Javier Roales, Jawad Hasan Shoqeir, Jean-Christophe Lata, Jean-Luc Probst, Jeyanny Vijayanathan, Jiri Dolezal, Joan-Albert Sanchez-Cabeza, Joël Merlet, John Loehr, Jonathan von Oppen, Jörg Löffler, José Luis Benito Alonso, José-Gilberto Cardoso-Mohedano, Josep Peñuelas, Joseph C. Morina, Juan Darío Quinde, Juan J. Jiménez, Juha M. Alatalo, Julia Seeber, Julia Kemppinen, Jutta Stadler, Kaie Kriiska, Karel Van den Meersche, Karibu Fukuzawa, Katalin Szlavecz, Katalin Juhos, Katarína Gerhátová, Kate Lajtha, Katie Jennings, Katja Tielbörger, Kazuhiko Hoshizaki, Ken Green, Klaus Steinbauer, Laryssa Pazianoto, Laura Dienstbach, Laura Yahdjian, Laura J. Williams, Laurel Brigham, Lee Hanna, Liesbeth van den Brink, Lindsey Rustad, Lourdes Morillas, Luciana Silva Carneiro, Luciano Di Martino, Luis Villar, Luísa Alícida Fernandes Tavares, Madison Morley, Manuela Winkler, Marc Lebouvier, Marcello Tomaselli, Marcus Schaub, Maria Glushkova, Maria Guadalupe Almazan Torres, Marie-Anne de Graaff, Marie-Noëlle Pons, Marijn Bauters, Marina Mazón, Mark Frenzel, Markus Wagner, Markus Didion, Maroof Hamid, Marta Lopes, Martha Apple, Martin Weih, Matej Mojses, Matteo Gualmini, Matthew Vadeboncoeur, Michael Bierbaumer, Michael Danger, Michael Scherer-Lorenzen, Michal Růžek, Michel Isabellon, Michele Di Musciano, Michele Carbognani, Miglena Zhiyanski, Mihai Puşcaş, Milan Barna, Mioko Ataka, Miska Luoto, Mohammed H. Alsafaran, Nadia Barsoum, Naoko Tokuchi, Nathalie Korboulewsky, Nicolas Lecomte, Nina Filippova, Norbert Hölzel, Olga Ferlian, Oscar Romero, Osvaldo Pinto-Jr, Pablo Peri, Pavel Dan Turtureanu, Peter Haase, Peter Macreadie, Peter B. Reich, Petr Petřík, Philippe Choler, Pierre Marmonier, Quentin Ponette, Rafael Dettogni Guariento, Rafaella Canessa, Ralf Kiese, Rebecca Hewitt, Robert Weigel, Róbert Kanka, Roberto Cazzolla Gatti, Rodrigo Lemes Martins, Romà Ogaya, Romain Georges, Rosario G. Gavilán, Sally Wittlinger, Sara Puijalon, Satoshi Suzuki, Schädler Martin, Schmidt Anja, Sébastien Gogo, Silvio Schueler, Simon Drollinger, Simone Mereu, Sonja Wipf, Stacey Trevathan-Tackett, Stefan Stoll, Stefan Löfgren, Stefan Trogisch, Steffen Seitz, Stephan Glatzel, Susanna Venn, Sylvie Dousset, Taiki Mori, Takanori Sato, Takuo Hishi, Tatsuro Nakaji, Theurillat Jean-Paul, Thierry Camboulive, Thomas Spiegelberger, Thomas Scholten, Thomas J. Mozdzer, Till Kleinebecker, Tomáš Rusňák, Tshililo Ramaswiela, Tsutom Hiura, Tsutomu Enoki, Tudor-Mihai Ursu, Umberto Morra di Cella, Ute Hamer, Valentin Klaus, Valter Di Cecco, Vanessa Rego, Veronika Fontana, Veronika Piscová, Vincent Bretagnolle, Vincent Maire, Vinicius Farjalla, Vittoz Pascal, Wenjun Zhou, Wentao Luo, William Parker, Yasuhiro Utsumi, Yuji Kominami, Zsolt Kotroczó, Zsolt Tóth

Publikováno v: Frontiers in Forests and Global Change, Vol 4 (2021)

Litter decomposition is a key process for carbon and nutrient cycling in terrestrial ecosystems and is mainly controlled by environmental conditions, substrate quantity and quality as well as microbial community abundance and composition. In particul

Externí odkaz: https://doaj.org/article/eb01b9333054413390facd023db3cd4f

Neurotrophin gene augmentation by electrotransfer to improve cochlear implant hearing outcomes

Autor: Jeremy L. Pinyon, Daniel Scherman, David McAlpine, Andrew K. Wise, Waikong Lai, Matthias Klugmann, James F. Patrick, Edward N. Crawford, Amr Al Abed, Corinne Marie, Paul Carter, Ya Lang Enke, Gary D. Housley, Robert K. Shepherd, Anne G M Schilder, Catherine M. McMahon, Georg von Jonquieres, Nigel H. Lovell, James B Fallon, Mayryl Duxbury, Catherine S. Birman

Publikováno v: Hearing Research
Hearing Research, Elsevier, 2019, 380, pp.137-149. ⟨10.1016/j.heares.2019.06.002⟩

International audience; This Review outlines the development of DNA-based therapeutics for treatment of hearing loss, and in particular, considers the potential to utilize the properties of recombinant neurotrophins to improve cochlear auditory (spir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::083cb56c4689e914ad028fce9710050e
https://hal-cnrs.archives-ouvertes.fr/hal-03292045

Influence of environment and substrate quality on root decomposition in naturally regenerating and restored Atlantic white cedar wetlands

Autor: Frank P. Day, Robert B. Atkinson, Edward R. Crawford

Publikováno v: Wetlands. 27:1-11

Restoration efforts and ecologically based management practices for Atlantic white cedar wetlands have recently focused on organic matter aggradation as an ecosystem function critical to this system’s maintenance. The objective of this study was to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0a2ed0f49aa971848de02634349fc99
https://doi.org/10.1672/0277-5212(2007)27[1:ioeasq]2.0.co

Close-Field Electroporation Gene Delivery Using the Cochlear Implant Electrode Array Enhances the Bionic Ear

Autor: Jeremy L. Pinyon, Edward N. Crawford, Ann Chi Yan Wong, Gary D. Housley, Isabella T. Tompson, Sherif F. Tadros, Kristina E. Froud, Renée Morris, Myungseo Ko, Matthias Klugmann

Publikováno v: Science Translational Medicine. 6

The cochlear implant is the most successful bionic prosthesis and has transformed the lives of people with profound hearing loss. However, the performance of the "bionic ear" is still largely constrained by the neural interface itself. Current spread

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2517183a8d1ead8d54e847f669f35ef3
https://doi.org/10.1126/scitranslmed.3008177