Zobrazeno 1 - 10
of 319
pro vyhledávání: '"Edward A Kolb"'
Autor:
Abdelrahman H. Elsayed, Xueyuan Cao, Richard J. Marrero, Nam H. K. Nguyen, Huiyun Wu, Yonhui Ni, Raul C. Ribeiro, Herold Tobias, Peter J. Valk, François Béliveau, Guillaume Richard-Carpentier, Josée Hébert, C. Michel Zwaan, Alan Gamis, Edward Anders Kolb, Richard Aplenc, Todd A. Alonzo, Soheil Meshinchi, Jeffrey Rubnitz, Stanley Pounds, Jatinder K. Lamba
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-12 (2024)
Abstract In this study, we leveraged machine-learning tools by evaluating expression of genes of pharmacological relevance to standard-AML chemotherapy (ara-C/daunorubicin/etoposide) in a discovery-cohort of pediatric AML patients (N = 163; NCT001360
Externí odkaz:
https://doaj.org/article/8d2e5546c18f4cf3998b81a1211405a0
Publikováno v:
Journal of High Energy Physics, Vol 2024, Iss 6, Pp 1-41 (2024)
Abstract The Kalb-Ramond field is an antisymmetric, rank-two tensor field which most notably appears in the context of string theory, but has largely been unexplored in the context of cosmology. In this work, motivated by the Kalb-Ramond field in str
Externí odkaz:
https://doaj.org/article/12eb4b6b9b2b49dc8fe0c6318a2b1b82
Autor:
Sonia Ahmed, Mariam Elsherif, Dina Yassin, Nahla Elsharkawy, Ayman S. Mohamed, Nouran Yasser, Amr Elnashar, Hanafy Hafez, Edward A. Kolb, Alaa Elhaddad
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundMolecular testing plays a pivotal role in monitoring measurable residual disease (MRD) in acute myeloid leukemia (AML), aiding in the refinement of risk stratification and treatment guidance. Wilms tumor gene 1 (WT1) is frequently upregulat
Externí odkaz:
https://doaj.org/article/b8f5691c0581409d84e6d241e1945e4b
Autor:
Andrew J. Menssen, Chad A. Hudson, Todd Alonzo, Robert Gerbing, Laura Pardo, Amanda Leonti, Jacqueline A. Cook, Fan-Chi Hsu, Loren L. Lott, Fangyan Dai, Collette Fearing, Keely Ghirardelli, Tiffany Hylkema, Katherine Tarlock, Keith R. Loeb, Edward A. Kolb, Todd Cooper, Jessica Pollard, Denise A. Wells, Michael R. Loken, Richard Aplenc, Soheil Meshinchi, Lisa Eidenschink Brodersen
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
As curative therapies for pediatric AML remain elusive, identifying potential new treatment targets is vital. We assessed the cell surface expression of CD74, also known as the MHC-II invariant chain, by multidimensional flow cytometry in 973 patient
Externí odkaz:
https://doaj.org/article/d6be1ca886894ebe8d63c195735d6fd2
Autor:
Anneke D. van Dijk, Fieke W. Hoff, Yihua Qiu, Stefan E. Hubner, Robin L. Go, Vivian R. Ruvolo, Amanda R. Leonti, Robert B. Gerbing, Alan S. Gamis, Richard Aplenc, Edward A. Kolb, Todd A. Alonzo, Soheil Meshinchi, Eveline S. J. M. de Bont, Terzah M. Horton, Steven M. Kornblau
Publikováno v:
Cancers, Vol 16, Iss 8, p 1448 (2024)
The addition of the proteasome inhibitor bortezomib to standard chemotherapy did not improve survival in pediatric acute myeloid leukemia (AML) when all patients were analyzed as a group in the Children’s Oncology Group phase 3 trial AAML1031 (NCT0
Externí odkaz:
https://doaj.org/article/993a21e3ecff4ccfa59731e0c4b20ed8
Publikováno v:
Journal of High Energy Physics, Vol 2023, Iss 5, Pp 1-51 (2023)
Abstract The phenomenon of cosmological gravitational particle production (CGPP) is expected to occur during the period of inflation and the transition into a hot big bang cosmology. Particles may be produced even if they only couple directly to grav
Externí odkaz:
https://doaj.org/article/3abd26dc51dd4c0a9882bee41df91f0e
Publikováno v:
Journal of High Energy Physics, Vol 2023, Iss 2, Pp 1-34 (2023)
Abstract We study cosmological gravitational particle production as applied to “rapid-turn” models of inflation involving two scalar fields. We are interested in the production of massive spin-0 particles that only interact gravitationally and pr
Externí odkaz:
https://doaj.org/article/4ef70d8517cc487c89af0204ec11dd03
Publikováno v:
Journal of High Energy Physics, Vol 2022, Iss 12, Pp 1-33 (2022)
Abstract Previous numerical investigations of gravitational particle production during the coherent oscillation period of inflation displayed unexplained fluctuations in the spectral density of the produced particles. We argue that these features are
Externí odkaz:
https://doaj.org/article/7e44fc9016ad4c65964f61dbbb50e076
Autor:
Valeria Ceolin, Sae Ishimaru, Seth E. Karol, Francisco Bautista, Bianca Frederika Goemans, Gwenaëlle Gueguen, Marieke Willemse, Laura Di Laurenzio, Jennifer Lukin, Harm van Tinteren, Franco Locatelli, Arnaud Petit, Daisuke Tomizawa, Alice Norton, Gertjan Kaspers, Dirk Reinhardt, Sarah K. Tasian, Gwen Nichols, Edward Anders Kolb, Christian Michel Zwaan, Todd Michael Cooper
Publikováno v:
Cancers, Vol 16, Iss 1, p 78 (2023)
The prognosis of children with acute myeloid leukemia (AML) has improved incrementally over the last few decades. However, at relapse, overall survival (OS) is approximately 40–50% and is even lower for patients with chemo-refractory disease. Effec
Externí odkaz:
https://doaj.org/article/60c20a1ab1ea4a858cada5db1f240e2b
Autor:
Eline J.M. Bertrums, Jenny L. Smith, Lauren Harmon, Rhonda E. Ries, Yi-Cheng J. Wang, Todd A. Alonzo, Andrew J. Menssen, Karen M. Chisholm, Amanda R. Leonti, Katherine Tarlock, Fabiana Ostronoff, Era L. Pogosova-Agadjanyan, Gertjan J.L. Kaspers, Henrik Hasle, Michael Dworzak, Christiane Walter, Nora Muhlegger, Cristina Morerio, Laura Pardo, Betsy Hirsch, Susana Raimondi, Todd M. Cooper, Richard Aplenc, Alan S. Gamis, Edward A. Kolb, Jason E. Farrar, Derek Stirewalt, Xiaotu Ma, Tim I. Shaw, Scott N. Furlan, Lisa Eidenschink Brodersen, Michael R. Loken, Marry M. van den Heuvel-Eibrink, C. Michel Zwaan, Timothy J. Triche, Bianca F. Goemans, Soheil Meshinchi
Publikováno v:
Haematologica, Vol 108, Iss 8 (2023)
NUP98 fusions comprise a family of rare recurrent alterations in AML, associated with adverse outcomes. In order to define the underlying biology and clinical implications of this family of fusions, we performed comprehensive transcriptome, epigenome
Externí odkaz:
https://doaj.org/article/831b66d955b24822ab485927eae2ccd2