Zobrazeno 1 - 1
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pro vyhledávání: '"Eduardo South San Francisco Setti"'
Autor:
Colena Johnson, James T. Palmer, Rohan Mendonca, Jean-Pierre Falgueyret, Renata Oballa, Gregg Wesolowski, M David Percival, Peppi Prasit, Cliff Bryant, Joël Robichaud, Eduardo South San Francisco Setti, Donald B. Kimmel, Shankar Venkatraman, Sevgi B. Rodan
Publikováno v:
Journal of Medicinal Chemistry. 46:3709-3727
A novel series of nonpeptidic biaryl compounds was identified as potent and reversible inhibitors of cathepsin K. The P2-P3 amide bond of a known amino acetonitrile dipeptide 1 was replaced with a phenyl ring, thereby giving rise to this biaryl serie