The Effect of Ursolic Acid on Leishmania (Leishmania) amazonensis Is Related to Programed Cell Death and Presents Therapeutic Potential in Experimental Cutaneous Leishmaniasis.

Autor: Eduardo S Yamamoto, Bruno L S Campos, Jéssica A Jesus, Márcia D Laurenti, Susan P Ribeiro, Esper G Kallás, Mariana Rafael-Fernandes, Gabriela Santos-Gomes, Marcelo S Silva, Deborah P Sessa, João H G Lago, Débora Levy, Luiz F D Passero

Publikováno v: PLoS ONE, Vol 10, Iss 12, p e0144946 (2015)

Among neglected tropical diseases, leishmaniasis is one of the most important ones, affecting more than 12 million people worldwide. The available treatments are not well tolerated, and present diverse side effects, justifying the search for new ther

Externí odkaz: https://doaj.org/article/67f9ade59978492c8c3ea6508e48bd9d

Therapeutic effect of ursolic acid in experimental visceral leishmaniasis

Autor: Márcia Dalastra Laurenti, Aurea F. Ferreira, Marcelo Silva, Jéssica Adriana Jesus, João Henrique G. Lago, Luiz Felipe Domingues Passero, Thais N. Fragoso, Gabriela S. Gomes, Eduardo S. Yamamoto

Publikováno v: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance, Vol 7, Iss 1, Pp 1-11 (2017)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Made available in DSpace on 2018-12-11T17:08:17Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-04-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Leishmaniasis is an important neglected tropical disease, affecting more th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda2b0022b44c2cd7259fbd124ec8015

Ursolic Acid Potentializes Conventional Therapy in Experimental Leishmaniasis

Autor: Márcia Dalastra Laurenti, Eduardo S. Yamamoto, João Henrique G. Lago, Jéssica Adriana Jesus, Thays Nicolli Fragoso da Silva, Luiz Felipe Domingues Passero

Publikováno v: Pathogens
Pathogens, Vol 9, Iss 855, p 855 (2020)
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Volume 9
Issue 10

Ursolic acid (UA) is a triterpene with a broad array of pharmacological activities. In leishmaniasis, UA killed different species of parasites, and it was active in the experimental model of cutaneous and visceral leishmaniasis. Thus, the objective o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4255451573d5e60d2e627e0df5f160e
https://doi.org/10.3390/pathogens9100855

Corrigendum to 'Therapeutic effect of ursolic acid in experimental visceral leishmaniasis' [Int. J. Parasitol. Drugs Drug Resist. 7 (2017) 1–11]

Autor: Eduardo S. Yamamoto, Gabriela Santos-Gomes, Aurea F. Ferreira, Luiz Felipe Domingues Passero, Thais N. Fragoso, João Henrique G. Lago, Marcelo Silva, Jéssica Adriana Jesus, Márcia Dalastra Laurenti

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 7, Iss 2, Pp 250-(2017)
International Journal for Parasitology: Drugs and Drug Resistance

Leishmaniasis is an important neglected tropical disease, affecting more than 12 million people worldwide. The available treatments are not well tolerated and present diverse side effects in patients, justifying the search for new therapeutic compoun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a48c0f4e443abf9b05a9c0a88c66a33
http://www.sciencedirect.com/science/article/pii/S2211320717300386

Antileishmanial Activity and Immunomodulatory Effects of Tricin Isolated from Leaves of Casearia arborea (Salicaceae)

Autor: Marta L. Lima, Márcia Dalastra Laurenti, Andre G. Tempone, Marisi G. Soares, Ligia F. Martins, Augusto L. Santos, Miriam Uemi, Patricia Sartorelli, Eduardo S. Yamamoto, João Henrique G. Lago, Luiz Felipe Domingues Passero

Publikováno v: Chemistry & Biodiversity. 14:e1600458

Bioactivity-guided fractionation of antileishmanial active extract from leaves of Casearia arborea led to isolation of three metabolites: tricin (1), 1',6'-di-O-β-d-vanilloyl glucopyranoside (2) and vanillic acid (3). Compound 1 demonstrated the hig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6d89e95dab6e1a4f424d485f356cf7f
https://doi.org/10.1002/cbdv.201600458