Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Eduardo Reyes-Vargas"'
Publikováno v:
The Journal of Biological Chemistry
Human leukocyte antigen-DM (HLA-DM) is an integral component of the major histocompatibility complex class II (MHCII) antigen-processing and -presentation pathway. HLA-DM shapes the immune system by differentially catalyzing peptide exchange on MHCII
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1de3a6fc4f6e2949fd4c52861f39aed
https://pubmed.ncbi.nlm.nih.gov/31969393
https://pubmed.ncbi.nlm.nih.gov/31969393
Autor:
Xiao He, Eduardo Reyes-Vargas, Hernando Escobar, Adam P. Barker, Alan L. Rockwood, Julio C. Delgado, Zemin Zhou, Kuan Y. Chang, Peter E. Jensen
Publikováno v:
European Journal of Immunology. 47:314-326
HLA-DM and class II associated invariant chain (Ii) are key cofactors in the MHC class II (MHCII) antigen processing pathway. We used tandem mass spectrometry sequencing to directly interrogate the global impact of DM and Ii on the repertoire of MHCI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7dd8845c8318e9b303739cfdb16ac534
https://doi.org/10.1002/eji.201646656
https://doi.org/10.1002/eji.201646656
Autor:
Xiao He, Eduardo Reyes-Vargas, Peter E. Jensen, Hernando Escobar, Alan L. Rockwood, Julio C. Delgado, Zemin Zhou, Brant Rudd
Publikováno v:
European Journal of Immunology. 46:834-845
HLA-DM is essential for editing peptides bound to MHC class II, thus influencing the repertoire of peptides mediating selection and activation of CD4(+) T cells. Individuals expressing HLA-DQ2 or DQ8, and DQ2/8 trans-dimers, have elevated risk for ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66fc890c52537a3068729d1caedaee28
https://doi.org/10.1002/eji.201545942
https://doi.org/10.1002/eji.201545942
Autor:
Zhenwei Song, Lan Li, Eduardo Reyes-Vargas, Peter E. Jensen, Huang Jufang, Fred Clayton, Xinjian Chen, Chengke Luo
Publikováno v:
Nanomedicine : nanotechnology, biology, and medicine. 14(2)
The finding of HER2 overexpression in osteosarcoma (OS) makes HER2 a potential therapeutic target. However, studies indicate OS cells are nonresponsive to anti-HER2 antibody trastuzumab (TRA) therapy. We established stable, non-covalent association o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::653f2d96a6c12abdd3d2e823c774c89f
https://pubmed.ncbi.nlm.nih.gov/29170110
https://pubmed.ncbi.nlm.nih.gov/29170110
Publikováno v:
The Journal of Immunology. 202:177.19-177.19
IFNγ inducible lysosomal thiol reductase (GILT) is the only thiol reductase localized in lysosomes and late endosomes, with its optimal activity at acidic pH. GILT is constitutively expressed in professional APC, further upregulated by IFNγ, and pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4e35d6abb4a8328d1b8f7c3db7cd415
https://doi.org/10.4049/jimmunol.202.supp.177.19
https://doi.org/10.4049/jimmunol.202.supp.177.19
Autor:
Noriyuki Sato, Hernando Escobar, Kristin Camfield Lind, Luc Van Kaer, Julio C. Delgado, Takayuki Kanaseki, Alan L. Rockwood, Eduardo Reyes-Vargas, Brant Rudd, Nilabh Shastri, Niranjana A. Nagarajan
Publikováno v:
The Journal of Immunology. 191:1547-1555
Effective CD8+ T cell responses depend on presentation of a stable peptide repertoire by MHC class I (MHC I) molecules on the cell surface. The overall quality of peptide–MHC I complexes (pMHC I) is determined by poorly understood mechanisms that g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b74430cd9fcae0cc2d54b38f83581643
https://doi.org/10.4049/jimmunol.1301043
https://doi.org/10.4049/jimmunol.1301043
Autor:
Hernando Escobar, Eduardo Reyes-Vargas, Mark C. Lloyd, Kevin Cronin, George Blanck, Alan L. Rockwood, Julio C. Delgado, Karoly Szekeres
Publikováno v:
Human Vaccines & Immunotherapeutics. 9:784-789
Numerous molecular effects have been attributed to histone deacetylase inhibitors (HDACI's), including the induction of major histocompatibility (MHC) genes. Here we report that one FDA approved HDACI, Vorinostat, and a second HDACI currently in clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ada0a112f8ad521f0ee2633133741755
https://doi.org/10.4161/hv.23085
https://doi.org/10.4161/hv.23085
Autor:
Ian A. York, David M. Valenzuela, Julio C. Delgado, George D. Yancopoulos, Eleanor Kincaid, Kenneth L. Rock, Margaret Karow, Jenny Wun-Yue Che, Hernando Escobar, Andrew J. Murphy, Eduardo Reyes-Vargas, Raymond M. Welsh
Publikováno v:
Nature immunology
The importance of immunoproteasomes to antigen presentation has been unclear because animals totally lacking immunoproteasomes had not been available. Having now developed mice lacking the three immunoproteasome catalytic subunits, we found that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5bf226d190cfc3f7ffcf8d8178a4538
https://doi.org/10.1038/ni.2203
https://doi.org/10.1038/ni.2203
Publikováno v:
The Journal of Immunology. 200:99.3-99.3
Gamma-IFN inducible lysosomal thiol reductase (GILT) is currently the only identified thiol reductase that has optimal activity at acidic pH and localizes to lysosomes. GILT is constitutively expressed in antigen presenting cells (APC), is inducible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74533ccbf9d0c2db8c7147646b4f3ce3
https://doi.org/10.4049/jimmunol.200.supp.99.3
https://doi.org/10.4049/jimmunol.200.supp.99.3