Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Eduardo R. Lazarowski"'
Autor:
Xiaomei Kong, William C. Bennett, Corey M. Jania, Kelly D. Chason, Zachary German, Jennifer Adouli, Samuel D. Budney, Brandon T. Oby, Catharina van Heusden, Eduardo R. Lazarowski, Ilona Jaspers, Scott H. Randell, Barry A. Hedgespeth, Glenn Cruse, Xiaoyang Hua, Stephen A. Schworer, Gregory J. Smith, Samir N.P. Kelada, Stephen L. Tilley
Publikováno v:
JCI Insight, Vol 6, Iss 21 (2021)
Ozone is a highly reactive environmental pollutant with well-recognized adverse effects on lung health. Bronchial hyperresponsiveness (BHR) is one consequence of ozone exposure, particularly for individuals with underlying lung disease. Our data demo
Externí odkaz:
https://doaj.org/article/226737900b334c5cb82e39193a8ffaf5
Publikováno v:
Life, Vol 11, Iss 5, p 430 (2021)
Mucociliary clearance (MCC) is a dominant component of pulmonary host defense. In health, the periciliary layer (PCL) is optimally hydrated, thus acting as an efficient lubricant layer over which the mucus layer moves by ciliary force. Airway surface
Externí odkaz:
https://doaj.org/article/22b9ca4970c1453d8e882a06125eda49
Autor:
Tobias Müller, Susanne Fay, Rodolfo Paula Vieira, Harry Karmouty-Quintana, Sanja Cicko, Cemil Korcan Ayata, Gernot Zissel, Torsten Goldmann, Giuseppe Lungarella, Davide Ferrari, Francesco Di Virgilio, Bernard Robaye, Jean-Marie Boeynaems, Eduardo R. Lazarowski, Michael R. Blackburn, Marco Idzko
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Idiopathic pulmonary fibrosis (IPF) is a disease with a poor prognosis and very few available treatment options. The involvement of the purinergic receptor subtypes P2Y2 and P2X7 in fibrotic lung disease has been demonstrated recently. In this study,
Externí odkaz:
https://doaj.org/article/5d30d0b580534cbfbfb47bc665ed4a96
Autor:
Kevin H.J. Park, Kristina Becanovic, Eduardo R. Lazarowski, David C. Walker, Sonia Franciosi, Blair R. Leavitt, Hélène C. F. Côté, Asghar Muhammad, Izabella Gadawska, Shiny Sachdeva
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 7, Iss 1, Pp 1-14 (2021)
NPJ Aging and Mechanisms of Disease
NPJ Aging and Mechanisms of Disease
Mitochondrial dysfunction and bioenergetics failure are common pathological hallmarks in Huntington’s disease (HD) and aging. In the present study, we used the YAC128 murine model of HD to examine the effects of mutant huntingtin on mitochondrial p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f444ff23778b7f5027d6f3bb75ddcfc7
https://doaj.org/article/9ed44fa1c2f0480fb9c59de967a2f4ca
https://doaj.org/article/9ed44fa1c2f0480fb9c59de967a2f4ca
Autor:
Eduardo R. Lazarowski, Brett S. Kirby, Matthew A. Sparks, Denise A Lopez Domowicz, Hongmei Zhu, Timothy J. McMahon
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 320:H1055-H1065
Export of vasodilator ATP from red blood cells requires pannexin 1. Blood plasma ATP elevations in response to hypoxia in mice require pannexin 1. Hemodynamic responses to hypoxia are accompanied by increased plasma ATP in mice in vivo and require pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4108a6466e3359afcf3642d44c854405
https://doi.org/10.1152/ajpheart.00651.2020
https://doi.org/10.1152/ajpheart.00651.2020
Autor:
Wanda K. O'Neal, Holger Stephan, Hong Dang, Neil E. Alexis, Richard C. Boucher, Wayne Anderson, Scott H. Donaldson, Brian Button, Lisa C. Morton, Catharina van Heusden, Agathe Ceppe, Eduardo R. Lazarowski
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Airway surface dehydration is a pathological feature of cystic fibrosis (CF) lung disease. CF is caused by mutations in the CF transmembrane conductance regulator (CFTR), a cyclic AMP-regulated Cl− channel controlled in part by the adenosine A2B re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ab1498ce0479dfa33374096a997e08
https://doi.org/10.1152/ajplung.00449.2019
https://doi.org/10.1152/ajplung.00449.2019
Autor:
Kristina Bečanović, Muhammad Asghar, Izabella Gadawska, Shiny Sachdeva, David Walker, Eduardo. R. Lazarowski, Sonia Franciosi, Kevin H. J. Park, Hélène C. F. Côté, Blair R. Leavitt
Publikováno v:
NPJ Aging and Mechanisms of Disease
npj Aging and Mechanisms of Disease, Vol 7, Iss 1, Pp 1-1 (2021)
npj Aging and Mechanisms of Disease, Vol 7, Iss 1, Pp 1-1 (2021)
Mitochondrial dysfunction and bioenergetics failure are common pathological hallmarks in Huntington's disease (HD) and aging. In the present study, we used the YAC128 murine model of HD to examine the effects of mutant huntingtin on mitochondrial par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57b6e63aad1760dd1cf1a13c71e20508
http://europepmc.org/articles/PMC8651687
http://europepmc.org/articles/PMC8651687
Autor:
Samuel D. Budney, Eduardo R. Lazarowski, Samir N. P. Kelada, Stephen L. Tilley, Glenn Cruse, Corey M. Jania, Ilona Jaspers, William C. Bennett, Brandon T. Oby, Scott H. Randell, Kelly D. Chason, Gregory J. Smith, Catharina van Heusden, Zachary German, Barry A. Hedgespeth, Jennifer Adouli, Xiaoyang Hua, Xiaomei Kong, Stephen A Schworer
Publikováno v:
JCI Insight
Ozone is a highly reactive environmental pollutant with well-recognized adverse effects on lung health. Bronchial hyperresponsiveness (BHR) is one consequence of ozone exposure, particularly for individuals with underlying lung disease. Our data demo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d9774b35163a8d1748261af2b99e931
http://europepmc.org/articles/PMC8663556
http://europepmc.org/articles/PMC8663556
Autor:
Katelyn S. Lavrich, Phillip W. Clapp, Eduardo R. Lazarowski, Ilona Jaspers, Johnny L. Carson, Catharina van Heusden
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 316:L470-L486
Aldehydes in cigarette smoke (CS) impair mitochondrial function and reduce ciliary beat frequency (CBF), leading to diminished mucociliary clearance (MCC). However, the effects of aldehyde e-cigarette flavorings on CBF are unknown. The purpose of thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6b0017a1e69eb53392578e7f8295f15
https://doi.org/10.1152/ajplung.00304.2018
https://doi.org/10.1152/ajplung.00304.2018
Publikováno v:
Life, Vol 11, Iss 430, p 430 (2021)
Life
Life
Mucociliary clearance (MCC) is a dominant component of pulmonary host defense. In health, the periciliary layer (PCL) is optimally hydrated, thus acting as an efficient lubricant layer over which the mucus layer moves by ciliary force. Airway surface
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff61160a647cbbac92bc109a08c5274f
https://www.mdpi.com/2075-1729/11/5/430
https://www.mdpi.com/2075-1729/11/5/430