Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Eduardo R. Cobo"'
Autor:
Ravi Holani, Chathurika Rathnayaka, Graham A.D. Blyth, Anshu Babbar, Priyoshi Lahiri, Daniel Young, Antoine Dufour, Morley D. Hollenberg, Derek M. McKay, Eduardo R. Cobo
Publikováno v:
Journal of Innate Immunity, Pp 1-18 (2022)
Cathelicidin peptides secreted by leukocytes and epithelial cells are microbicidal but also regulate pathogen sensing via toll-like receptors (TLRs) in the colon by mechanisms that are not fully understood. Herein, analyses with the attaching/effacin
Externí odkaz:
https://doaj.org/article/ba4d2e7029b243e9afdccaf552cfcee9
Autor:
Lisa Gamsjäger, Karina M. Cirone, Steffany Schluessel, Mackenzie Campsall, Aydin Herik, Priyoshi Lahiri, Daniel Young, Antoine Dufour, Panagiotis Sapountzis, Saria Otani, Diego E. Gomez, M. Claire Windeyer, Eduardo R. Cobo
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
IntroductionCalves are highly susceptible to gastrointestinal infection with Cryptosporidium parvum (C. parvum), which can result in watery diarrhea and eventually death or impaired development. With little to no effective therapeutics, understanding
Externí odkaz:
https://doaj.org/article/1bc03cea11c541a2afb7c5cce34a8cca
Autor:
Sohrab Khan, Tian Wang, Eduardo R. Cobo, Bingchun Liang, Muhammad Asfandyar Khan, Maolin Xu, Weijie Qu, Jian Gao, Herman W. Barkema, John P. Kastelic, Gang Liu, Bo Han
Publikováno v:
Antioxidants, Vol 13, Iss 2, p 171 (2024)
Streptococcus uberis mastitis in cattle infects mammary epithelial cells. Although oxidative responses often remove intracellular microbes, S. uberis survives, but the mechanisms are not well understood. Herein, we aimed to elucidate antioxidative me
Externí odkaz:
https://doaj.org/article/e7228df6c3134b73877aed7c646186b1
Autor:
Ramon Roca-Pinilla, Ravi Holani, Adrià López-Cano, Cristina Saubi, Ricardo Baltà-Foix, Eduardo R. Cobo, Elena Garcia-Fruitós, Anna Arís
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Combining several innate immune peptides into a single recombinant antimicrobial and immunomodulatory polypeptide has been recently demonstrated. However, the versatility of the multidomain design, the role that each domain plays and how the
Externí odkaz:
https://doaj.org/article/b8fbcb974f6a418d8562af3da15c591b
Autor:
Mariano Larzábal, Wanderson Marques Da Silva, Anmol Multani, Lucas E. Vagnoni, Dadin P. Moore, Maia S. Marin, Nahuel A. Riviere, Fernando O. Delgado, Daniel A. Vilte, Matias Romero Victorica, Tao Ma, Luo Le Guan, Paola Talia, Angel Cataldi, Eduardo R. Cobo
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Abstract The zoonotic enterohemorrhagic Escherichia coli (EHEC) O157: H7 bacterium causes diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome (HUS) in humans. Cattle are primary reservoirs and EHEC O157: H7; the bacteria predominately inhabi
Externí odkaz:
https://doaj.org/article/684ce949019a4947a8777d93b4f24afa
Autor:
Blanca E. Callejas, Graham A. D. Blyth, Nicholas Jendzjowsky, Arthur Wang, Anshu Babbar, Konstantin Koro, Richard J. A. Wilson, Margaret M. Kelly, Eduardo R. Cobo, Derek M. McKay
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The murine interleukin-4 treated macrophage (MIL4) exerts anti-inflammatory and pro-healing effects and has been shown to reduce the severity of chemical-induced colitis. Positing M(IL4) transfer as an anti-inflammatory therapy, the possibility of si
Externí odkaz:
https://doaj.org/article/251b4328e7ca45afa2a4d2fd7994eddd
Autor:
Ravi Holani, Anshu Babbar, Graham A. D. Blyth, Fernando Lopes, Humberto Jijon, Derek M. McKay, Morley D. Hollenberg, Eduardo R. Cobo
Publikováno v:
Gut Microbes, Vol 12, Iss 1 (2020)
We hypothesized that the antimicrobial peptide cathelicidin has a physiological role in regulating gut inflammatory homeostasis. We determined that cathelicidin synergizes with LPS to facilitate its internalization and signaling via endosomic TLR4 in
Externí odkaz:
https://doaj.org/article/ac13c2c2683f4f61b068423c553476e5
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Host defense peptides, abundantly secreted by colonic epithelial cells and leukocytes, are proposed to be critical components of an innate immune response in the colon against enteropathogenic bacteria, including Shigella spp., Salmonella spp., Clost
Externí odkaz:
https://doaj.org/article/79d582973e654c1780c6c8d2c34e08cb
Autor:
Muhammad Shahid, Paloma Araujo Cavalcante, Cameron G. Knight, Herman W. Barkema, Bo Han, Jian Gao, Eduardo R. Cobo
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Prototheca bovis (formerly P. zopfii genotype-II) is an opportunistic, achlorophyllous alga that causes mastitis in cows and skin disease in cats and dogs, as well as cutaneous lesions in both immunocompetent and immunosuppressed humans. Antifungal m
Externí odkaz:
https://doaj.org/article/4d6d0bace4c34451923d77ab8a555108
Autor:
Rakel Arrazuria, Cameron G. Knight, Priyoshi Lahiri, Eduardo R. Cobo, Herman W. Barkema, Jeroen De Buck
Publikováno v:
Microorganisms, Vol 8, Iss 10, p 1507 (2020)
Digital dermatitis (DD) causes lameness in cattle with substantial negative impact on sustainability and animal welfare. Although several species of Treponema bacteria have been isolated from various DD stages, their individual or synergistic roles i
Externí odkaz:
https://doaj.org/article/073ef5e659c74d079b6afd0b5b1318a1