Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Eduardo Pinho Melo"'
Autor:
Eduardo Pinho Melo, Tasuku Konno, Ilaria Farace, Mosab Ali Awadelkareem, Lise R. Skov, Fernando Teodoro, Teresa P. Sancho, Adrienne W. Paton, James C. Paton, Matthew Fares, Pedro M. R. Paulo, Xin Zhang, Edward Avezov
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Aggregation of misfolded proteins underlie dementias. Here, the authors show that stressed cells activate an innate mechanism to resolve aggregates of defective proteins in the endoplasmic reticulum, where a third of cellular proteins are produced.
Externí odkaz:
https://doaj.org/article/604b027e6238474bb516b4dc28bbd629
Autor:
Eduardo Pinho Melo, Carlos Lopes, Peter Gollwitzer, Stephan Lortz, Sigurd Lenzen, Ilir Mehmeti, Clemens F. Kaminski, David Ron, Edward Avezov
Publikováno v:
BMC Biology, Vol 15, Iss 1, Pp 1-15 (2017)
Abstract Background The fate of hydrogen peroxide (H2O2) in the endoplasmic reticulum (ER) has been inferred indirectly from the activity of ER-localized thiol oxidases and peroxiredoxins, in vitro, and the consequences of their genetic manipulation,
Externí odkaz:
https://doaj.org/article/922d71cfe9cb41b1949d315efd61a13f
Publikováno v:
Cells, Vol 10, Iss 2, p 233 (2021)
Reactive oxygen species (ROS) are produced continuously throughout the cell as products of various redox reactions. Yet these products function as important signal messengers, acting through oxidation of specific target factors. Whilst excess ROS pro
Externí odkaz:
https://doaj.org/article/b4b7ccd9ac4b4d84a11e9b8e177c862a
Autor:
Satoshi Tsunoda, Edward Avezov, Alisa Zyryanova, Tasuku Konno, Leonardo Mendes-Silva, Eduardo Pinho Melo, Heather P Harding, David Ron
Publikováno v:
eLife, Vol 3 (2014)
Protein folding homeostasis in the endoplasmic reticulum (ER) requires efficient protein thiol oxidation, but also relies on a parallel reductive process to edit disulfides during the maturation or degradation of secreted proteins. To critically exam
Externí odkaz:
https://doaj.org/article/676eee2fd8be4f8abfed0abf85054431
Laccases belong to the large family of multi-copper oxidases (MCOs) that couple the one-electron oxidation of substrates with the four-electron reduction of molecular oxygen to water. Because of their high relative non-specific oxidation capacity par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73139e8f276c4a3cf770ff594c768b80