Distinct pathogenic roles for resident and monocyte-derived macrophages in lupus nephritis

Autor: Nathan Richoz, Zewen K. Tuong, Kevin W. Loudon, Eduardo Patiño-Martínez, John R. Ferdinand, Jorge Romo-Tena, Anaïs Portet, Kathleen R. Bashant, Emeline Thevenon, Francesca Rucci, Thomas Hoyler, Tobias Junt, Mariana J. Kaplan, Richard M. Siegel, Menna R. Clatworthy

Publikováno v: JCI Insight, Vol 7, Iss 21 (2023)

Lupus nephritis is a serious complication of systemic lupus erythematosus, mediated by IgG immune complex (IC) deposition in kidneys, with limited treatment options. Kidney macrophages are critical tissue sentinels that express IgG-binding Fcγ recep

Externí odkaz: https://doaj.org/article/d738063f70d840b2bb17022567be68e4

Mosquito salivary apyrase regulates blood meal hemostasis and facilitates malaria parasite transmission

Autor: Zarna Rajeshkumar Pala, Thiago Luiz Alves e Silva, Mahnaz Minai, Benjamin Crews, Eduardo Patino-Martinez, Carmelo Carmona-Rivera, Paola Carolina Valenzuela Leon, Ines Martin-Martin, Yevel Flores-Garcia, Raul E. Cachau, Liya Muslinkina, Apostolos G. Gittis, Naman Srivastava, David N. Garboczi, Derron A. Alves, Mariana J. Kaplan, Elizabeth Fischer, Eric Calvo, Joel Vega-Rodriguez

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract The evolution of hematophagy involves a series of adaptations that allow blood-feeding insects to access and consume blood efficiently while managing and circumventing the host’s hemostatic and immune responses. Mosquito, and other insects

Externí odkaz: https://doaj.org/article/5f36b17f5200404f8da58a835144cc00

Host-Derived Lipids from Tuberculous Pleurisy Impair Macrophage Microbicidal-Associated Metabolic Activity

Autor: Pablo Schierloh, Domingo Palmero, Rogelio Hernández-Pando, Geanncarlo Lugo-Villarino, Arnaud Métais, Alison Charton, Christel Vérollet, Eduardo Patiño-Martínez, Omar Emiliano Aparicio-Trejo, Matias Ostrowski, Olivier Neyrolles, José Pedraza-Chaverri, Emilie Layre, Isabelle Maridonneau-Parini, María Belén Dolotowicz, Luciana Balboa, Carmen Sánchez-Torres, Eduardo José Moraña, Denis Hudrisier, José Luis Marín Franco, Malena Ferreyra, Gabriel Duette, María del Carmen Sasiain, Yoann Rombouts, Mariano Maio, Federico Fuentes, Vanessa Soldan, Dan Corral, Melanie Genoula

Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2020, 33 (13), pp.108547. ⟨10.1016/j.celrep.2020.108547⟩
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Mycobacterium tuberculosis (Mtb) regulates the macrophage metabolic state to thrive in the host, yet the responsible mechanisms remain elusive. Macrophage activation toward the microbicidal (M1) program depends on the HIF-1α-mediated metabolic shift

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a16b6644bd486ae260f40bfca9ef06
https://hal.archives-ouvertes.fr/hal-03367701