Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Eduardo Palao"'
Autor:
Veronika Dockalova, Esther M. Sanchez-Carnerero, Zuzana Dunajova, Eduardo Palao, Michaela Slanska, Tomas Buryska, Jiri Damborsky, Petr Klán, Zbynek Prokop
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 922-932 (2020)
Haloalkane dehalogenases are enzymes that catalyze the cleavage of carbon-halogen bonds in halogenated compounds. They serve as model enzymes for studying structure–function relationships of >100.000 members of the α/β-hydrolase superfamily. Deta
Externí odkaz:
https://doaj.org/article/4aa30111aa5244fbb827a6b37ba28055
Publikováno v:
Flow and Microreactor Technology in Medicinal Chemistry. :67-102
Autor:
Irini, Abdiaj, Santiago, Cañellas, Alejandro, Dieguez, Maria Lourdes, Linares, Brenda, Pijper, Alberto, Fontana, Raquel, Rodriguez, Andres, Trabanco, Eduardo, Palao, Jesus, Alcázar
Publikováno v:
Journal of medicinal chemistry.
Herein, we report an end-to-end process including synthesis, work-up, purification, and post-purification with minimal human intervention using Negishi coupling as a key transformation to increase Fsp
Autor:
Michal Poljak, Lucie Wohlrábová, Eduardo Palao, Jela Nociarová, Jiří Míšek, Tomáš Slanina, Petr Klán
Publikováno v:
Chemical communications (Cambridge, England). 58(44)
Many serious diseases are associated with degenerative changes caused by oxidative stress triggered by elevated concentrations of reactive oxygen species (ROS) in cells. Therefore, the development of suitable probes for monitoring such processes is o
Autor:
Eduardo Palao, Iván Torres-Moya, Antonio de la Hoz, Angel Díaz-Ortiz, Jesús Alcázar, Enol López
Publikováno v:
RUIdeRA. Repositorio Institucional de la UCLM
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Formation of all-carbon-substituted quaternary carbons is a key challenge in organic and medicinal chemistry. We report a cobalt-catalyzed C(sp3)–C(sp3) cross-coupling that allows for the introduction of benzyl, heteroarylmethylzinc and allyl group
Autor:
Michaela Slanska, Petr Klán, Zuzana Dunajova, Esther M. Sánchez-Carnerero, Tomas Buryska, Veronika Dockalova, Jiri Damborsky, Eduardo Palao, Zbynek Prokop
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 922-932 (2020)
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 922-932 (2020)
Graphical abstract
Highlights • The first fluorescent substrates for haloalkane dehalogenases. • Potent probes for kinetic analysis and high-throughput activity screening. • Provide high specificity and efficiency for protein labelling.
Highlights • The first fluorescent substrates for haloalkane dehalogenases. • Potent probes for kinetic analysis and high-throughput activity screening. • Provide high specificity and efficiency for protein labelling.
Autor:
Eduardo Palao, Maria J. Ortiz, Virginia Martínez-Martínez, Andrea Tabero, Rebeca Sola-Llano, Hegoi Manzano, Iñigo López-Arbeloa, Antonia R. Agarrabeitia, Angeles Villanueva
Publikováno v:
Repositorio Institucional del Instituto Madrileño de Estudios Avanzados en Nanociencia
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Biscyclometalated IrIII complexes involving boron-dipyrromethene (BODIPY)-based ancillary ligands, where the BODIPY unit is grafted to different chelating cores (acetylacetonate for Ir-1 and Ir-2, and bipyridine for Ir-3) by the BODIPY meso position,
Autor:
Andrea Tabero, Santiago de la Moya, Maria J. Ortiz, Eduardo Palao, Antonia R. Agarrabeitia, Alejandro Prieto-Castañeda, Fernando García-Garrido, Inmaculada García-Moreno, Angeles Villanueva
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Repositorio Institucional del Instituto Madrileño de Estudios Avanzados en Nanociencia
Universidad de Alicante (UA)
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Repositorio Institucional del Instituto Madrileño de Estudios Avanzados en Nanociencia
Universidad de Alicante (UA)
4 pags., 3 figs., 1 tab.
Endowing BODIPY PDT agents with the ability to probe lipid droplets is demonstrated to boost their phototoxicity, allowing the efficient use of highly fluorescent dyes (poor ROS sensitizers) as phototoxic agents. Convers
Endowing BODIPY PDT agents with the ability to probe lipid droplets is demonstrated to boost their phototoxicity, allowing the efficient use of highly fluorescent dyes (poor ROS sensitizers) as phototoxic agents. Convers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d2cdd6b0142b4f9d459110c99a990a1
http://hdl.handle.net/10261/218787
http://hdl.handle.net/10261/218787
Autor:
Noël Boens, Antonia R. Agarrabeitia, Miriam Madrid, Wim Dehaen, Santiago de la Moya, Maria J. Ortiz, Eduardo Palao, Gonzalo Duran-Sampedro, Carmen García-López, Bram Verbelen
Publikováno v:
The Journal of Organic Chemistry. 81:3700-3710
The generality of the palladium-catalyzed C–C coupling Negishi reaction when applied to haloBODIPYs is demonstrated on the basis of selected starting BODIPYs, including polyhalogenated and/or asymmetrical systems, and organozinc reagents. This reac
Publikováno v:
Journal of the American Chemical Society. 138:126-133
Carbon monoxide-releasing molecules (CORMs) are chemical agents used to administer CO as an endogenous, biologically active molecule. A precise spatial and temporal control over the CO release is the major requirement for their applications. Here, we