Výsledky vyhledávání - "Eduardo Martinez-Soria"

Expression of aberrant forms of CD22 on B lymphocytes in Cd22a lupus-prone mice affects ligand binding

Autor: Liza Ho, Frédéric Lajaunias, Carolin Dix, Eduardo Martinez-Soria, Lars Nitschke, Shozo Izui, Shuichi Kikuchi, Thomas Moll, R. Michael E. Parkhouse, Marie-Laure Santiago-Raber

Publikováno v: International Immunology, Vol. 18, No 1 (2006) pp. 59-68

CD22 functions primarily as a negative regulator of B-cell receptor signaling. The Cd22a allele has been proposed as a candidate allele for murine systemic lupus erythematosus. In this study, we explored the possible expression of aberrant forms of C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89cf9c09265b624ad0fea203752ae567
http://doc.rero.ch/record/290776/files/dxh349.pdf

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Differential Contribution of Three Activating IgG Fc Receptors (FcγRI, FcγRIII, and FcγRIV) to IgG2a- and IgG2b-Induced Autoimmune Hemolytic Anemia in Mice

Autor: Falk Nimmerjahn, Shozo Izui, Samareh Azeredo da Silveira, Michael C. Carroll, Eduardo Martinez-Soria, Lucie Clementine Baudino, Jeffrey V. Ravetch, Takashi Saito, J. Sjef Verbeek

Publikováno v: Journal of Immunology, Vol. 180, No 3 (2008) pp. 1948-53

Murine phagocytes express three different activating IgG FcgammaR: FcgammaRI is specific for IgG2a; FcgammaRIII for IgG1, IgG2a, and IgG2b; and FcgammaRIV for IgG2a and IgG2b. Although the role of FcgammaRIII in IgG1 and IgG2a anti-RBC-induced autoim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9ba67205b4f8c08508d0f74ca54a3a
https://doi.org/10.4049/jimmunol.180.3.1948

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Differential Activation of Anti-Erythrocyte and Anti-DNA Autoreactive B Lymphocytes by the Yaa Mutation

Autor: Marie-Laure Santiago-Raber, Maria Pihlgren-Bosch, Thomas Moll, Dragan Marinkovic, Shozo Izui, Hirofumi Amano, Eduardo Martinez-Soria

Publikováno v: Journal of Immunology
Journal of Immunology, Vol. 174, No 2 (2005) pp. 702-709

An as-yet-unidentified mutation, Y-linked autoimmune acceleration (Yaa), is responsible for the accelerated development of lupus-like autoimmune syndrome in mice. In view of a possible role for Yaa as a positive regulator of BCR signaling, we have ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8162c3f66bdbd4ea45d81fd63e7b71
https://doi.org/10.4049/jimmunol.174.2.702

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Epitope-Dependent Inhibition of T Cell Activation by the Ea Transgene: An Explanation for Transgene-Mediated Protection from Murine Lupus

Autor: Marie-Laure Santiago-Raber, Nabila Ibnou-Zekri, Marie Kosco-Vilbois, Shuichi Kikuchi, Eduardo Martinez-Soria, Shozo Izui, Masahiro Iwamoto

Publikováno v: Journal of Immunology, Vol. 173, No 4 (2004) pp. 2842-2848

A high level expression of the Ead transgene encoding the I-E α-chain is highly effective in the suppression of lupus autoantibody production in mice. To explore the possible modulation of the Ag-presenting capacity of B cells as a result of the tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa295f1ee09c83845e9db2475ea8ceb6
https://doi.org/10.4049/jimmunol.173.4.2842

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Differential control of CD22 ligand expression on B and T lymphocytes, and enhanced expression in murine systemic lupus

Autor: Eduardo Martinez-Soria, Shuichi Kikuchi, Akinori Ida, Frédéric Lajaunias, Che-Leung Law, Shozo Izui, Thomas Moll, Liliane Fossati-Jimack

Publikováno v: Arthritis and Rheumatism, Vol. 48, No 6 (2003) pp. 1612-1621

Objective CD22, a B cell–restricted transmembrane glycoprotein, regulates B cell antigen receptor signaling upon interaction with α2,6-linked sialic acid–bearing glycans, which act as ligands and are expressed on B and T cells. In this study, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c194b4631f3c59e888afe34942391d8a
https://doi.org/10.1002/art.11021

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Differentially Regulated Expression and Function of CD22 in Activated B-1 and B-2 Lymphocytes

Autor: Shozo Izui, R. Michael E. Parkhouse, Thomas Moll, Yves Chicheportiche, Isabelle Semac, Lars Nitschke, Frédéric Lajaunias, Eduardo Martinez-Soria

Publikováno v: Journal of Immunology, Vol. 168, No 12 (2002) pp. 6078-6083
Scopus-Elsevier
CIÊNCIAVITAE

CD22 is a B cell-restricted transmembrane protein that apparently controls signal transduction thresholds initiated through the B cell Ag receptor (BCR) in response to Ag. However, it is still poorly understood how the expression of CD22 is regulated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a33ec62626860cdc3e0f48868372dc40
https://doi.org/10.4049/jimmunol.168.12.6078

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REGULATION OF MHC CLASS II GENES: Lessons from a Disease

Autor: Walter Reith, Bernard Mach, Eduardo Martinez-Soria, Viktor Steimle

Publikováno v: Annual Review of Immunology, Vol. 14 (1996) pp. 301-331

▪ Abstract Precise regulation of major histocompatibility complex class II (MHC-II) gene expression plays a crucial role in the control of the immune response. A major breakthrough in the elucidation of the molecular mechanisms involved in MHC-II r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c49b88f49f2cca4b89f687c12ab64ef5
https://doi.org/10.1146/annurev.immunol.14.1.301

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A novel antigen-processing-defective phenotype in major histocompatibility complex class II-positive CIITA transfectants is corrected by interferon-gamma

Autor: Bernard Mach, Claire-Anne Siegrist, Eduardo Martinez-Soria, Ilse Kern

Publikováno v: The Journal of Experimental Medicine

Presentation of exogenous protein antigens to T lymphocytes is based on the intersection of two complex pathways: (a) synthesis, assembly, and transport of major histocompatibility complex (MHC) class II-invariant chain complexes from the endoplasmic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b02da27135a169466c8092296c8f0ad
https://doi.org/10.1084/jem.182.6.1793

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An HLA-DRB α-helix motif shared by DR11 and DR8 alleles is implicated in the pluriallelic restriction of peptide-specific T-cell lines

Autor: Eduardo Martinez-Soria, Charlotte Burkhardt, Jean-Marie Tiercy, Claude Irlé, Bernard Mach, Viktor Steimle, Pascale Beffy, Jörg T. Epplen

Publikováno v: Human Immunology. 40:279-290

The T-cell recognition of HLA-DR-peptide complexes is generally restricted by the polymorphism of the DRB molecules but pluriallelic restriction has been described. The molecular basis of restriction and promiscuity of such peptide-specific responses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e430770719d39f5d393cfccc5c7b86
https://doi.org/10.1016/0198-8859(94)90027-2

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Crucial role of aspartic acid at position 265 in the CH2 domain for murine IgG2a and IgG2b Fc-associated effector functions

Autor: Shin-Ichiro Nishimura, Munehiro Nakata, Eduardo Martinez-Soria, Franz Petry, Shozo Izui, Falk Nimmerjahn, Jeffery V. Ravetch, Jun-ichi Furukawa, Lucie Clementine Baudino, Yasuro Shinohara

Publikováno v: Journal of Immunology, Vol. 181, No 9 (2008) pp. 6664-9

Replacement of aspartic acid by alanine at position 265 (D265A) in mouse IgG1 results in a complete loss of interaction between this isotype and low-affinity IgG Fc receptors (FcγRIIB and FcγRIII). However, it has not yet been defined whether the D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::223a803ca665810dfbaefda77ba9b514
https://pubmed.ncbi.nlm.nih.gov/18941257

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