Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Eduardo Manta"'
Autor:
Cristina Quiroga, Marcelo Incerti, Diego Benitez, Eduardo Manta, Andrea Medeiros, Marcelo A. Comini
Publikováno v:
Frontiers in Chemical Biology, Vol 3 (2024)
Trypanosoma cruzi is the etiologic agent of Chagas’ disease, a debilitating and mortal zoonotic illness that threatens the lives of several millions of people in the American continent. The acute phase is underdiagnosed and there is no curative tre
Externí odkaz:
https://doaj.org/article/53e87e20ac534bea9c4c565a318587a7
Autor:
Santiago M. Ruatta, Denis N. Prada Gori, Martín Fló Díaz, Franca Lorenzelli, Karen Perelmuter, Lucas N. Alberca, Carolina L. Bellera, Andrea Medeiros, Gloria V. López, Mariana Ingold, Williams Porcal, Estefanía Dibello, Irina Ihnatenko, Conrad Kunick, Marcelo Incerti, Martín Luzardo, Maximiliano Colobbio, Juan Carlos Ramos, Eduardo Manta, Lucía Minini, María Laura Lavaggi, Paola Hernández, Jonas Šarlauskas, César Sebastian Huerta García, Rafael Castillo, Alicia Hernández-Campos, Giovanni Ribaudo, Giuseppe Zagotto, Renzo Carlucci, Noelia S. Medrán, Guillermo R. Labadie, Maitena Martinez-Amezaga, Carina M. L. Delpiccolo, Ernesto G. Mata, Laura Scarone, Laura Posada, Gloria Serra, Theodora Calogeropoulou, Kyriakos Prousis, Anastasia Detsi, Mauricio Cabrera, Guzmán Alvarez, Adrián Aicardo, Verena Araújo, Cecilia Chavarría, Lucija Peterlin Mašič, Melisa E. Gantner, Manuel A. Llanos, Santiago Rodríguez, Luciana Gavernet, Soonju Park, Jinyeong Heo, Honggun Lee, Kyu-Ho Paul Park, Mariela Bollati-Fogolín, Otto Pritsch, David Shum, Alan Talevi, Marcelo A. Comini
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: The identification of chemical compounds that interfere with SARS-CoV-2 replication continues to be a priority in several academic and pharmaceutical laboratories. Computational tools and approaches have the power to integrate, process
Externí odkaz:
https://doaj.org/article/37a7aaacc38c4e40801eaddd5b8743ba
Autor:
Beatriz Munguía, Jenny Saldaña, Magdalena Nieves, María Elisa Melian, Manuela Ferrer, Ramiro Teixeira, Williams Porcal, Eduardo Manta, Laura Domínguez
Publikováno v:
Parasites & Vectors, Vol 15, Iss 1, Pp 1-11 (2022)
Abstract Background Helminthiasis and resistance to commercial anthelmintic compounds are major causes of economic losses for livestock producers, resulting in an urgent need for new drugs and reliable in vitro screening tests capable of detecting po
Externí odkaz:
https://doaj.org/article/89fb89d7e7bf467b931d492e2d6c6b7b
Publikováno v:
Molecules, Vol 5, Iss 3, Pp 313-314 (2000)
The synthesis of new anthelmintic compounds derived from 2-amine-4-hydroxy-δ-valerolactams and 2,4-dialkylthiazoles is described. The synthetic procedures and biological activity data for these compounds will be presented.
Externí odkaz:
https://doaj.org/article/6a65ca5b7a5146e5b20adac7657decc8
Autor:
Eduardo Manta, Juan Carlos Ramos, Maximiliano Colobbio, Gerardo Duarte, María Elisa Melian, Mauricio Silvera, Ramiro Teixeira, Laura Dominguez
Publikováno v:
Letters in Drug Design & Discovery. 20:225-231
Background: Infections caused by helminth parasites are the main cause of economic losses in the livestock industry worldwide. The rapid resistance acquired by different parasites against commercially available drugs motivates the search, design and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::078c68ddeb413944cc5f5a2deee59e05
https://doi.org/10.2174/1570180819666220414101412
https://doi.org/10.2174/1570180819666220414101412
Autor:
Juan Carlos Ramos, Francisco Carrau, Eduardo Dellacassa, Rafael Radi, Eduardo Manta, Maria José Valera, Eduardo Boido
Publikováno v:
Appl Environ Microbiol
Benzenoid-derived metabolites act as precursors for a wide variety of products involved in essential metabolic roles in eukaryotic cells. They are synthesized in plants and some fungi through the phenylalanine ammonia lyase (PAL) and tyrosine ammonia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf14785e3aafbac4731f8b07daa1af4
https://europepmc.org/articles/PMC7440790/
https://europepmc.org/articles/PMC7440790/
Autor:
Santiago Daniel Palma, Ricardo Faccio, Maria Elisa Melian, Laura Domínguez, Maximiliano Colobbio, Ramiro Teixeira, Juan Carlos Ramos, Eduardo Manta, Beatriz Munguía, Alejandro Javier Paredes
Publikováno v:
AAPS PharmSciTech. 21
Valero-fenbendazole (VAL-FBZ) is a novel hybrid compound with in vitro anthelmintic activity, designed and synthesized to address the global problem of resistance to anthelmintic compounds. This new molecule derives from fenbendazole (FBZ), a well-kn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796c553803866d57e0b72688f989fe76
https://doi.org/10.1208/s12249-020-01777-y
https://doi.org/10.1208/s12249-020-01777-y
Autor:
Eduardo Manta, Lindsay B. Stewart, Diver Sellanes, Laura Scarone, Gloria Serra, Marcelo A. Comini, Vanessa Yardley, Andrea Medeiros, Judit Tulla-Puche, Stella Peña, Catherine Fagundez, Fernando Albericio
Publikováno v:
Med. Chem. Commun.. 5:1309-1316
Cyclohexapeptide analogs of natural products were obtained in very good yields by a combination of solid-phase peptide synthesis, for the linear peptide, and solution cyclization. The activities against Plasmodium falciparum K1, Trypanosoma brucei br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0b244513628217bda601a7234218a58
https://doi.org/10.1039/c4md00135d
https://doi.org/10.1039/c4md00135d
Autor:
Andrés López, Eduardo Manta, Laura Domínguez, Pablo Mendina, Ximena Ures, Jenny Saldaña, Romina Espinosa, Andrea Lanz, María J. Andina, Beatriz Munguía
Publikováno v:
Letters in Drug Design & Discovery. 10:1007-1014
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6e229209c14980ade3258f700416778
https://doi.org/10.2174/15701808113109990028
https://doi.org/10.2174/15701808113109990028
Autor:
Laura Scarone, Gloria Serra, Eduardo Manta, Stella Peña, Lindsay B. Stewart, Vanessa Yardley, Simon L. Croft
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4994-4997
The synthesis of a Microcystis aeruginosa predicted metabolite analog of aerucyclamide B was performed. This hexacyclopeptide was obtained from three heterocyclic building blocks by a convergent macrocycle-assembly methodology. The compound exhibited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f36b69c6f8308730860b84ad1bba451
https://doi.org/10.1016/j.bmcl.2012.06.028
https://doi.org/10.1016/j.bmcl.2012.06.028