Leptin-mediated reactive oxygen species production does not significantly affect primary mouse hepatocyte functions in vitro

Autor: Ben Schroyen, Eduardo MacHado Guimaraes, Laurent Dolle, Christophe Empsen, Marc Nyssen, Albert Geerts, Isabelle Colle, Leo van Grunsven

Publikováno v: Vrije Universiteit Brussel

AIM: Direct and indirect effects of leptin on hepatic stellate cells (HSCs) have been documented in the literature, whereas little is known about leptin's actions on hepatocytes. Leptin mediates its profibrogenic and proinflammatory effects on HSCs i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::23270cafd531e23a2c30f1d6356b2c8a
https://biblio.vub.ac.be/vubir/leptinmediated-reactive-oxygen-species-production-does-not-significantly-affect-primary-mouse-hepatocyte-functions-in-vitro(261970af-9e5b-4fe6-9b32-3659ae9032c0).html

Mitochondrial uncouplers inhibit hepatic stellate cell activation

Autor: Mustapha Najimi, Eduardo MacHado Guimaraes, Jan Best, Leonardus Van Grunsven, Etienne Sokal, Laurent Dollé

Publikováno v: BMC Gastroenterology, Vol. 12, no. 6, p. 68 [1-12] (2012)
BMC Gastroenterology; Vol 12
BMC Gastroenterology, Vol 12, Iss 1, p 68 (2012)
BMC Gastroenterology

Background Mitochondrial dysfunction participates in the progression of several pathologies. Although there is increasing evidence for a mitochondrial role in liver disease, little is known about its contribution to hepatic stellate cell (HSC) activa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::040b4dd0d102a4de47dc5491fcebbf9c
https://biblio.vub.ac.be/vubir/mitochondrial-uncouplers-inhibit-hepatic-stellate-cell-activation(b34d32fa-85dd-4bc2-8116-58cdd44ecf7b).html

Autophagy:A new player in hepatic stellate cell activation

Autor: Lien F R Thoen, Eduardo MacHado Guimaraes, Leonardus Van Grunsven

Publikováno v: Vrije Universiteit Brussel

Hepatic stellate cell (HSC) activation, the transition from a resident quiescent HSC to a myofibroblastic collagen-producing HSC, is a fundamental feature of liver fibrosis. Autophagy has been implicated in major liver pathologies, such as HCV infect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1b4f16edccf46b696a74972beea33b
https://cris.vub.be/en/publications/autophagya-new-player-in-hepatic-stellate-cell-activation(812dad0b-fb5c-40ab-a539-bf011c4c6b3e).html