Characterization of a novel HMG-CoA lyase enzyme with a dual location in endoplasmic reticulum and cytosol

Autor: María Arnedo, Sebastián Menao, Beatriz Puisac, María E. Teresa-Rodrigo, María C. Gil-Rodríguez, Eduardo López-Viñas, Paulino Gómez-Puertas, Nuria Casals, César H. Casale, Fausto G. Hegardt, Juan Pié

Publikováno v: Journal of Lipid Research, Vol 53, Iss 10, Pp 2046-2056 (2012)

A novel lyase activity enzyme is characterized for the first time: HMG-CoA lyase-like1 (er-cHL), which is a close homolog of mitochondrial HMG-CoA lyase (mHL). Initial data show that there are nine mature transcripts for the novel gene HMGCLL1, altho

Externí odkaz: https://doaj.org/article/5844f0ad725743b480b2902a3d0484a1

Modulating the RNA processing and decay by the exosome: altering Rrp44/Dis3 activity and end-product.

Autor: Filipa P Reis, Ana Barbas, A A Klauer-King, Borislava Tsanova, Daneen Schaeffer, Eduardo López-Viñas, Paulino Gómez-Puertas, Ambro van Hoof, Cecília M Arraiano

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e76504 (2013)

In eukaryotes, the exosome plays a central role in RNA maturation, turnover, and quality control. In Saccharomyces cerevisiae, the core exosome is composed of nine catalytically inactive subunits constituting a ring structure and the active nuclease

Externí odkaz: https://doaj.org/article/2d714601448b4199ab3fcd54cddfb9e4

Mutations That Hamper Dimerization of Foot-and-Mouth Disease Virus 3A Protein Are Detrimental for Infectivity

Autor: María F. Rosas, Yuri A. Vieira, Francisco Sobrino, David Andreu, Beatriz G. de la Torre, Leonor Kremer, Mónica González-Magaldi, Raúl Postigo, Miguel Rodríguez-Pulido, Paulino Gómez-Puertas, Eduardo López-Viñas

Publikováno v: Journal of Virology; Vol 86
Repositorio de Resultados de Investigación del INIA
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria INIA
INIA: Repositorio de Resultados de Investigación del INIA
Digital.CSIC. Repositorio Institucional del CSIC
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Foot-and-mouth disease virus (FMDV) nonstructural protein 3A plays important roles in virus replication, virulence, and host range. In other picornaviruses, homodimerization of 3A has been shown to be relevant for its biological activity. In this wor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5a4b43ae7068e1a6ee0134340e50081

Structural and Functional Model for Ionic (K+/Na+) and pH Dependence of GTPase Activity and Polymerization of FtsZ, the Prokaryotic Ortholog of Tubulin

Autor: Ana Isabel Rico, Eduardo López-Viñas, Jesús Mingorance, Paulino Gómez-Puertas, Jesús Mendieta, Miguel Vicente

Publikováno v: Journal of Molecular Biology; Vol 390
Digital.CSIC. Repositorio Institucional del CSIC
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Bacterial cell division occurs through the formation of a protein ring (division ring) at the site of division, with FtsZ being its main component in most bacteria. FtsZ is the prokaryotic ortholog of eukaryotic tubulin; it shares GTPase activity pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fe6f8bebf861ffd8f77637fe7a5daf8

New Insights into the Mechanism of RNA Degradation by Ribonuclease II

Autor: Eduardo López-Viñas, Mónica Amblar, Paulino Gómez-Puertas, Ana Barbas, Rute G. Matos, Cecília M. Arraiano

Publikováno v: Journal of Biological Chemistry. 283:13070-13076

RNase II is a key exoribonuclease involved in the maturation, turnover, and quality control of RNA. RNase II homologues are components of the exosome, a complex of exoribonucleases. The structure of RNase II unraveled crucial aspects of the mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e94a96a506455915635221d027d7e0c
https://doi.org/10.1074/jbc.m709989200