Výsledky vyhledávání - "Eduardo Horjales"

Akademický článek

Molecular Characterization of Trypanosoma evansi Mevalonate Kinase (TeMVK)

Autor: Daniel P. Duarte, Éden R. Ferreira, Fabio M. Lima, Franciane Batista, Michel De Groote, Eduardo Horjales, Luiz C. Miletti, Diana Bahia

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)

The mevalonate pathway is an essential part of isoprenoid biosynthesis leading to production of a diverse class of >30,000 biomolecules including cholesterol, heme, and all steroid hormones. In trypanosomatids, the mevalonate pathway also generates d

Externí odkaz: https://doaj.org/article/2034eea0dc56480fa5195345cfb4deb7

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Akademický článek

Computer simulations reveal changes in the conformational space of the transcriptional regulator MosR upon the formation of a disulphide bond and in the collective motions that regulate its DNA-binding affinity.

Autor: Amanda Souza Câmara, Eduardo Horjales

Publikováno v: PLoS ONE, Vol 13, Iss 2, p e0192826 (2018)

M. tuberculosis oxidation sense Regulator (MosR) is a transcriptional regulator from Mycobacterium tuberculosis. It senses the environment oxidation and regulates the expression of a secreted oxidoreductase, thus defending the bacilli against oxidati

Externí odkaz: https://doaj.org/article/1fb07244bac04796bfeb5005a1581b10

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Autor: Eduardo Horjales, Amanda Souza Câmara

Publikováno v: PLoS ONE
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS ONE, Vol 13, Iss 2, p e0192826 (2018)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8635b021cc0b4d5694847cd180ac0f
http://europepmc.org/articles/PMC5823404

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Unique behavior of Trypanosoma cruzi mevalonate kinase: A conserved glycosomal enzyme involved in host cell invasion and signaling

Autor: Mario Cruz, Cristian Cortez, Michel De Groote, Eduardo Horjales, Renato A. Mortara, Fabio Mitsuo Lima, Éden Ramalho Ferreira, Tiago J. P. Sobreira, Claudio Vieira da Silva, José Franco da Silveira, Alexis Bonfim-Melo, Esteban Mauricio Cordero, Diana Bahia, Nobuko Yoshida

Publikováno v: Repositório Institucional da UNIFESP
Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Scientific Reports

FAPESP CAPES CNPq Mevalonate kinase (MVK) is an essential enzyme acting in early steps of sterol isoprenoids biosynthesis, such as cholesterol in humans or ergosterol in trypanosomatids. MVK is conserved from bacteria to mammals, and localizes to gly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ec9d4a1555f98c4dfe6316d5c1622e

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Structure–Function Relationships in Fungal Large-Subunit Catalases

Autor: Adelaida Díaz, Wilhelm Hansberg, Eduardo Horjales, Víctor Valdés, Enrique Rudiño-Piñera

Publikováno v: Journal of Molecular Biology. 386:218-232

Neurospora crassa has two large-subunit catalases, CAT-1 and CAT-3. CAT-1 is associated with non-growing cells and accumulates particularly in asexual spores; CAT-3 is associated with growing cells and is induced under different stress conditions. It

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8798fb648710501ecd64ae20b567b769
https://doi.org/10.1016/j.jmb.2008.12.019

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The Crystal Structure of A Ternary Complex of Betaine Aldehyde Dehydrogenase from Pseudomonas aeruginosa Provides New Insight into the Reaction Mechanism and Shows A Novel Binding Mode of the 2′-Phosphate of NADP+ and A Novel Cation Binding Site

Autor: Lilian González-Segura, Enrique Rudiño-Piñera, Rosario A. Muñoz-Clares, Eduardo Horjales

Publikováno v: Journal of Molecular Biology. 385:542-557

In the human pathogen Pseudomonas aeruginosa, the NAD(P)(+)-dependent betaine aldehyde dehydrogenase (PaBADH) may play the dual role of assimilating carbon and nitrogen from choline or choline precursors--abundant at infection sites--and producing gl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e495c842c0e76d11792382f5aeae272
https://doi.org/10.1016/j.jmb.2008.10.082

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The structure of the giant haemoglobin from Glossoscolex paulistus

Autor: Allen M. Orville, Eduardo Horjales Reboredo, Richard Charles Garratt, Marcel Tabak, José Brandão-Neto, José Fernando Ruggiero Bachega, Marcelo Falsarella Carazzollea, Fernando V. Maluf, Humberto D'Muniz Pereira, Babak Andi

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

The sequences of all seven polypeptide chains from the giant haemoglobin of the free-living earthwormGlossoscolex paulistus(HbGp) are reported together with the three-dimensional structure of the 3.6 MDa complex which they form. The refinement of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514809d626f87ae7830e0e47819412db

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Structural and functional characterization of a recombinant sticholysin I (rSt I) from the sea anemone Stichodactyla helianthus

Autor: Eduardo Lissi, C. Alvarez, A. Valle, Javier Campos, Rafael Fando, María E. Lanio, L. Calderón, Eduardo Horjales, Amaury Pupo, A. Ramírez, Fabiola Pazos, Diana Martinez, Vivian Morera, Shirley Schreier, Mayra Tejuca, Fabio Henrique Dyszy

Publikováno v: TOXICON
Artículos CONICYT
CONICYT Chile
instacron:CONICYT

Sticholysins I and II (Sts I and II) are two potent cytolysins from the sea anemone Stichodactyla helianthus. These isoforms present 13 substitutions, with three non-conservative located at the N-terminus. St II is considerably more hemolytic than St

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1721ea31a9fd13d68fab316564337ca4
https://doi.org/10.1016/j.toxicon.2006.09.004

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Homology Modeling and Site-directed Mutagenesis of Pyroglutamyl Peptidase II

Autor: Lucía Chávez-Gutiérrez, Jean-Louis Charli, Bernard Maigret, Eduardo Horjales, Joel Osuna, Edna Matta-Camacho, Patricia Joseph-Bravo

Publikováno v: Journal of Biological Chemistry. 281:18581-18590

Pyroglutamyl peptidase II (PPII), a highly specific membrane-bound omegapeptidase, removes N-terminal pyroglutamyl from thyrotropin-releasing hormone (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad8ad2d1e41854d8599d783662af2376
https://doi.org/10.1074/jbc.m601392200

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Bacterial expression, purification and functional characterization of a recombinant chimeric Fab derived from murine mAb BCF2 that neutralizes the venom of the scorpion Centruroides noxius hoffmann

Autor: Barbara Selisko, Consuelo Medina García, Baltazar Becerril, Eduardo Horjales, Lourival D. Possani, Gabriela Cosío

Publikováno v: Toxicon. 43:43-51

The murine monoclonal antibody BCF2 is able to neutralize the venom of the scorpion Centruroides noxius Hoffmann. A chimeric Fab of BCF2 (chFab-BCF2) comprising the variable regions of murine BCF2 and human constant regions was assembled. chFab-BCF2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7b1b95ef08ab89c305a9605cb60ac4
https://doi.org/10.1016/j.toxicon.2003.10.015

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