Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Eduardo H, Gilglioni"'
Autor:
Eduardo H. Gilglioni, Ao Li, Wadsen St-Pierre-Wijckmans, Tzu-Keng Shen, Israel Pérez-Chávez, Garnik Hovhannisyan, Michela Lisjak, Javier Negueruela, Valerie Vandenbempt, Julia Bauzá-Martinez, Jose M. Herranz, Daria Ezeriņa, Stéphane Demine, Zheng Feng, Thibaut Vignane, Lukas Otero Sanchez, Flavia Lambertucci, Alena Prašnická, Jacques Devière, David C. Hay, Jose A. Encinar, Sumeet Pal Singh, Joris Messens, Milos R. Filipovic, Hayley J. Sharpe, Eric Trépo, Wei Wu, Esteban N. Gurzov
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Fat accumulation, de novo lipogenesis, and glycolysis are key drivers of hepatocyte reprogramming and the consequent metabolic dysfunction-associated steatotic liver disease (MASLD). Here we report that obesity leads to dysregulated expressi
Externí odkaz:
https://doaj.org/article/47d15d12bd9c4154ade149ceeddbddb9
Autor:
Israel Pérez-Chávez, John N. Koberstein, Julia Malo Pueyo, Eduardo H. Gilglioni, Didier Vertommen, Nicolas Baeyens, Daria Ezeriņa, Esteban N. Gurzov, Joris Messens
Publikováno v:
iScience, Vol 27, Iss 12, Pp 111336- (2024)
Summary: HYlight is a genetically encoded fluorescent biosensor that ratiometrically monitors fructose 1,6-bisphosphate (FBP), a key glycolytic metabolite. Given the role of glucose in liver cancer metabolism, we expressed HYlight in human liver canc
Externí odkaz:
https://doaj.org/article/06432e888eac46fea648d28577fa9519
Autor:
Stephanie Talamantes, Michela Lisjak, Eduardo H. Gilglioni, Camilo J. Llamoza-Torres, Bruno Ramos-Molina, Esteban N. Gurzov
Publikováno v:
JHEP Reports, Vol 5, Iss 9, Pp 100811- (2023)
Summary: Obesity-related complications such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D) are well-established risk factors for the development of hepatocellular carcinoma (HCC). This review provides insights into the molecul
Externí odkaz:
https://doaj.org/article/bdc6868083954ef9bc3215c297727189
Autor:
Tatiana Takiishi, Peng Xiao, Marie Franchimont, Eduardo H. Gilglioni, Erick N. Arroba, Esteban N. Gurzov, Mathieu JM. Bertrand, Alessandra K. Cardozo
Publikováno v:
Molecular Metabolism, Vol 69, Iss , Pp 101681- (2023)
Objectives: Type 1 diabetes (T1D) is caused by progressive immune-mediated loss of insulin-producing β-cells. Inflammation is detrimental to β-cell function and survival, moreover, both apoptosis and necrosis have been implicated as mechanisms of
Externí odkaz:
https://doaj.org/article/43ae0b3ebd974c21b9e2c60cf2ed9866
Autor:
Arthur J. Verhoeven, Paulo F.V. Bizerra, Eduardo H. Gilglioni, Simei Go, Hang Lam Li, Ronald P.J. Oude Elferink, Jung-Chin Chang
SummaryCyclic AMP is produced in cells by two different types of adenylyl cyclases: at the plasma membrane by the transmembrane adenylyl cyclases (tmACs, ADCY1∼ADCY9) and in the cytosol by the evolutionarily more conserved soluble adenylyl cyclase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::223e8d690f55d0a5a71699dfae560b51
https://doi.org/10.1101/2022.09.01.505928
https://doi.org/10.1101/2022.09.01.505928
Autor:
Lonny R. Levin, Arthur J. Verhoeven, Eduardo H. Gilglioni, Hang Lam Li, Richard J. Rodenburg, Simei Go, Daan M. Panneman, Jung-Chin Chang, Ronald P.J. Oude Elferink, Suzanne Duijst, Jochen Buck, Hsu-Li Huang
Publikováno v:
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1862(4):148367. Elsevier
Biochimica et Biophysica Acta. Bioenergetics, 1862, 4
Biochimica et Biophysica Acta. Bioenergetics, 1862
Biochimica et Biophysica Acta. Bioenergetics, 1862, 4
Biochimica et Biophysica Acta. Bioenergetics, 1862
Contains fulltext : 231545.pdf (Publisher’s version ) (Open Access) The evolutionarily conserved soluble adenylyl cyclase (sAC, ADCY10) mediates cAMP signaling exclusively in intracellular compartments. Because sAC activity is sensitive to local co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b500d958f9e3f61fd42f544fa49f31d
https://pure.amc.nl/en/publications/soluble-adenylyl-cyclase-regulates-the-cytosolic-nadhnad-redox-state-and-the-bioenergetic-switch-between-glycolysis-and-oxidative-phosphorylation(ace0b296-6c12-4419-92dd-6d7f8c2e96c4).html
https://pure.amc.nl/en/publications/soluble-adenylyl-cyclase-regulates-the-cytosolic-nadhnad-redox-state-and-the-bioenergetic-switch-between-glycolysis-and-oxidative-phosphorylation(ace0b296-6c12-4419-92dd-6d7f8c2e96c4).html
Autor:
Jung-Chin, Chang, Simei, Go, Eduardo H, Gilglioni, Suzanne, Duijst, Daan M, Panneman, Richard J, Rodenburg, Hang Lam, Li, Hsu-Li, Huang, Lonny R, Levin, Jochen, Buck, Arthur J, Verhoeven, Ronald P J, Oude Elferink
Publikováno v:
Biochimica et biophysica acta. Bioenergetics. 1862(4)
The evolutionarily conserved soluble adenylyl cyclase (sAC, ADCY10) mediates cAMP signaling exclusively in intracellular compartments. Because sAC activity is sensitive to local concentrations of ATP, bicarbonate, and free Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c0514ed7dbb77991170b0a7a0d0d02d7
https://pubmed.ncbi.nlm.nih.gov/33412125
https://pubmed.ncbi.nlm.nih.gov/33412125
Autor:
Simei Go, H. L. Li, Jung-Chin Chang, H.-L. Huang, Jochen Buck, Eduardo H. Gilglioni, R.P.J. Oude Elferink, Lonny R. Levin, Arthur J. Verhoeven
Cyclic AMP is produced in cells by two very different types of adenylyl cyclases: the canonical transmembrane adenylyl cyclases (tmACs,ADCY1∼9) and the evolutionarily more conserved soluble adenylyl cyclase (sAC,ADCY10). While the role and regulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ef9bc9ec7b3e0d9475332b9ec0c2b3
https://doi.org/10.1101/2020.02.02.929901
https://doi.org/10.1101/2020.02.02.929901
Autor:
Emy Luiza Ishii-Iwamoto, Arthur J. Verhoeven, Ruurdtje Hoekstra, Eduardo H. Gilglioni, Simei Go, Ronald P.J. Oude Elferink, Aziza A. A. Adam, Jung-Chin Chang, Suzanne Duijst
Publikováno v:
Hepatology Communications
Hepatology communications, 2(3), 299-312. Wiley-Blackwell Publishing Ltd
Hepatology communications, 2(3), 299-312. Wiley-Blackwell Publishing Ltd
Primary hepatocyte culture is an important in vitro system for the study of liver functions. In vivo, hepatocytes have high oxidative metabolism. However, oxygen supply by means of diffusion in in vitro static cultures is much less than that by blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26cb61dc8957ff9e546ebed1790b0634
http://europepmc.org/articles/PMC5831026
http://europepmc.org/articles/PMC5831026
Autor:
Ronald P.J. Oude Elferink, Eduardo H. Gilglioni, Jurgen H. Runge, Dirk R. de Waart, Clairce Luzia Salgueiro, Emy Luiza Ishii-Iwamoto, Ingrid C. Gaemers, Bouke A. de Boer, Monique Cristine de Oliveira
Publikováno v:
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1862(11), 2054-2062. Elsevier
Menopause is often followed by obesity and, related to this, non-alcoholic fatty liver disease (NAFLD). Two bile acid (BA) receptors, farnesoid X receptor (FXR) and G-protein-coupled receptor TGR5, have emerged as putative therapeutic targets for obe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8095db43d02d2300763594675e2932a4
https://pubmed.ncbi.nlm.nih.gov/27475255
https://pubmed.ncbi.nlm.nih.gov/27475255