Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Eduardo Felipe Alves Fernandes"'
Publikováno v:
Antioxidants, Vol 10, Iss 4, p 528 (2021)
Inflammation is one key process in driving cellular redox homeostasis toward oxidative stress, which perpetuates inflammation. In the brain, this interplay results in a vicious cycle of cell death, the loss of neurons, and leakage of the blood–brai
Externí odkaz:
https://doaj.org/article/f90e18aaa20141a1912e3599bfe40686
Autor:
Mie Kristensen, Krzysztof Kucharz, Eduardo Felipe Alves Fernandes, Kristian Strømgaard, Morten Schallburg Nielsen, Hans Christian Cederberg Helms, Anders Bach, Malte Ulrikkaholm Tofte-Hansen, Blanca Irene Aldana Garcia, Martin Lauritzen, Birger Brodin
Publikováno v:
Pharmaceutics, Vol 12, Iss 7, p 661 (2020)
Novel stroke therapies are needed. Inhibition of the interaction between the postsynaptic density-95 (PSD-95)/disc large/ZO-1 (PDZ) domains of PSD-95 and the N-methyl-D-aspartate (NMDA) receptor has been suggested as a strategy for relieving neuronal
Externí odkaz:
https://doaj.org/article/d683f301943540a996288fab6024152a
Publikováno v:
Biblioteca Digital de Teses e Dissertações da USPUniversidade de São PauloUSP.
Apesar do amplo e histórico uso de produtos da biodiversidade brasileira com fins medicinais, pouco se sabe sobre o destino destes produtos após a sua absorção no organismo; quais são os produtos de metabolismo formados, sua toxicidade e cinéti
Autor:
Jonas Wilbs, René Raavé, Milou Boswinkel, Tine Glendorf, David Rodríguez, Eduardo Felipe Alves Fernandes, Sandra Heskamp, Inga Bjørnsdottir, Magnus B. F. Gustafsson
Publikováno v:
Journal of Medicinal Chemistry, 66, 12, pp. 7772-7784
Item does not contain fulltext Positron emission tomography (PET) imaging is used in drug development to noninvasively measure biodistribution and receptor occupancy. Ideally, PET tracers retain target binding and biodistribution properties of the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47380998fec417298c64b58d390f6caf
https://doi.org/10.1021/acs.jmedchem.2c02073
https://doi.org/10.1021/acs.jmedchem.2c02073
Autor:
Eduardo Felipe Alves Fernandes, Norberto Peporine Lopes, Thais Guaratini, Anderson Rodrigo Moraes de Oliveira, Valeria Priscila de Barros
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
The cytochrome P450 is a remarkable family of enzymes with widespread occurrence in animals and plants. In humans, they catalyze phase I metabolism reactions, such as oxidations and hydroxylations, playing a significant role in xenobiotics detoxifica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ad31a99faa5cff98567227d4541fe2
https://doi.org/10.1007/s43450-020-00084-8
https://doi.org/10.1007/s43450-020-00084-8
Autor:
Eduardo Felipe Alves Fernandes, Jonas Wilbs, Rene Raavé, Christian Borch Jacobsen, Hanne Toftelund, Hans Helleberg, Milou Boswinkel, Sandra Heskamp, Magnus Bernt Frederik Gustafsson, Inga Bjørnsdottir
Publikováno v:
ACS Pharmacology & Translational Science, 5, 616-624
ACS Pharmacology & Translational Science, 5, 8, pp. 616-624
ACS Pharmacology & Translational Science, 5, 8, pp. 616-624
Contains fulltext : 283307.pdf (Publisher’s version ) (Closed access) Positron emission tomography (PET) is a molecular imaging modality that enables non-invasive visualization of tracer distribution and pharmacology. Recently, peptides with long h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e4e5feec7be46af6b559edf526abc7
https://doi.org/10.1021/acsptsci.2c00075
https://doi.org/10.1021/acsptsci.2c00075
Autor:
Jan Daberger, Louise S. Clemmensen, Kristian Strømgaard, Eduardo Felipe Alves Fernandes, Flor Abalde-Gil, Weontae Lee, Pascale Zimmermann, Raphael Leblanc, Petra Hamerlik, Renaud Vincentelli, Jeanette Hammer Andersen, Zeyu Jin, Vita Sereikaite, Bianca Wind, Marte Albrigtsen, Thomas M. T. Jensen, Maria Vistrup-Parry, Antonio L. Egea-Jimenez, Diana Aguilar-Morante, Linda M. Haugaard-Kedström, Kamilla E. Jensen, Ylva Ivarsson
Publikováno v:
Haugaard-Kedstrom, L M, Clemmensen, L S, Sereikaite, V, Jin, Z, Fernandes, E F A, Wind, B, Abalde-Gil, F, Daberger, J, Vistrup-Parry, M, Aguilar-Morante, D, Leblanc, R, Egea-Jimenez, A L, Albrigtsen, M, Jensen, K E, Jensen, T M T, Ivarsson, Y, Vincentelli, R, Hamerlik, P, Andersen, J H, Zimmermann, P, Lee, W & Stromgaard, K 2021, ' A High-Affinity Peptide Ligand Targeting Syntenin Inhibits Glioblastoma ', Journal of Medicinal Chemistry, vol. 64, no. 3, pp. 1423-1434 . https://doi.org/10.1021/acs.jmedchem.0c00382
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2021, 64 (3), pp.1423-1434. ⟨10.1021/acs.jmedchem.0c00382⟩
Journal of Medicinal Chemistry, 2021, 64 (3), pp.1423-1434. ⟨10.1021/acs.jmedchem.0c00382⟩
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2021, 64 (3), pp.1423-1434. ⟨10.1021/acs.jmedchem.0c00382⟩
Journal of Medicinal Chemistry, 2021, 64 (3), pp.1423-1434. ⟨10.1021/acs.jmedchem.0c00382⟩
This document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of Medicinal Chemistry, copyright © 2021 American Chemical Society, after peer review and technical editing by the publisher. To access t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8215a973d5782c2b47dd3c1eb5542d4f
https://curis.ku.dk/ws/files/313014309/syntenin_manuscript_JMC_revised_120820_VS_1_1_.pdf
https://curis.ku.dk/ws/files/313014309/syntenin_manuscript_JMC_revised_120820_VS_1_1_.pdf
Autor:
Blanca Irene Aldana Garcia, Martin Lauritzen, Birger Brodin, Anders Bach, Morten Nielsen, Hans Christian Cederberg Helms, Krzysztof Kucharz, Kristian Strømgaard, Eduardo Felipe Alves Fernandes, Malte Ulrikkaholm Tofte-Hansen, Mie Kristensen
Publikováno v:
Kristensen, M, Kucharz, K, Felipe Alves Fernandes, E, Strømgaard, K, Schallburg Nielsen, M, Cederberg Helms, H C, Bach, A, Ulrikkaholm Tofte-Hansen, M, Irene Aldana Garcia, B, Lauritzen, M & Brodin, B 2020, ' Conjugation of Therapeutic PSD-95 Inhibitors to the Cell-Penetrating Peptide Tat Affects Blood-Brain Barrier Adherence, Uptake, and Permeation ', Pharmaceutics, vol. 12, no. 7, 661 . https://doi.org/10.3390/pharmaceutics12070661
Kristensen, M, Kucharz, K, Felipe Alves Fernandes, E, Strømgaard, K, Schallburg Nielsen, M, Cederberg Helms, H C, Bach, A, Ulrikkaholm Tofte-Hansen, M, Irene Aldana Garcia, B, Lauritzen, M & Brodin, B 2020, ' Conjugation of Therapeutic PSD-95 Inhibitors to the Cell-Penetrating Peptide Tat Affects Blood-Brain Barrier Adherence, Uptake, and Permeation ', Pharmaceutics, vol. 12, no. 7, 661, pp. 1-24 . https://doi.org/10.3390/pharmaceutics12070661
Pharmaceutics
Volume 12
Issue 7
Pharmaceutics, Vol 12, Iss 661, p 661 (2020)
Kristensen, M, Kucharz, K, Felipe Alves Fernandes, E, Strømgaard, K, Schallburg Nielsen, M, Cederberg Helms, H C, Bach, A, Ulrikkaholm Tofte-Hansen, M, Irene Aldana Garcia, B, Lauritzen, M & Brodin, B 2020, ' Conjugation of Therapeutic PSD-95 Inhibitors to the Cell-Penetrating Peptide Tat Affects Blood-Brain Barrier Adherence, Uptake, and Permeation ', Pharmaceutics, vol. 12, no. 7, 661, pp. 1-24 . https://doi.org/10.3390/pharmaceutics12070661
Pharmaceutics
Volume 12
Issue 7
Pharmaceutics, Vol 12, Iss 661, p 661 (2020)
Novel stroke therapies are needed. Inhibition of the interaction between the postsynaptic density-95 (PSD-95)/disc large/ZO-1 (PDZ) domains of PSD-95 and the N-methyl-D-aspartate (NMDA) receptor has been suggested as a strategy for relieving neuronal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::859fd8f7e0a346cd79e21d11ac901f2b
https://doi.org/10.3390/pharmaceutics12070661
https://doi.org/10.3390/pharmaceutics12070661
Publikováno v:
Australian Journal of Chemistry. 73:307
Stability and cell permeability are critical parameters in the development of peptide therapeutics. Conjugation to fatty acids and cell-penetrating peptides, such as TAT (YGRKKRRQRRR), are established strategies to increase peptide stability and perm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8685e1f31970414f87e5ce18069ee89
https://doi.org/10.1071/ch19392
https://doi.org/10.1071/ch19392
Publikováno v:
Springer Series in Translational Stroke Research ISBN: 9783319453446
During ischemia and stroke, a large excess of glutamate is released from the presynaptic terminal into the synaptic cleft. The NMDA receptor is activated by glutamate in the presence of glycine and triggers an influx of Ca2+ and hence induces excitot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b20eff9a40356b609e152f983353117d
https://doi.org/10.1007/978-3-319-45345-3_6
https://doi.org/10.1007/978-3-319-45345-3_6