Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Eduardo Eyras"'
Autor:
Alexandra Sneddon, Agin Ravindran, Somasundhari Shanmuganandam, Madhu Kanchi, Nadine Hein, Simon Jiang, Nikolay Shirokikh, Eduardo Eyras
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The heterogeneous composition of cellular transcriptomes poses a major challenge for detecting weakly expressed RNA classes, as they can be obscured by abundant RNAs. Although biochemical protocols can enrich or deplete specified RNAs, they
Externí odkaz:
https://doaj.org/article/6d601da1932d46d78fbe992d27181081
Autor:
Héctor Franco-Valls, Elsa Tusquets-Uxó, Laura Sala, Maria Val, Raúl Peña, Alessandra Iaconcig, Álvaro Villarino, Martín Jiménez-Arriola, Pere Massó, Juan L. Trincado, Eduardo Eyras, Andrés F. Muro, Jorge Otero, Antonio García de Herreros, Josep Baulida
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-19 (2023)
Abstract Background As in most solid cancers, the emergence of cells with oncogenic mutations in the mammary epithelium alters the tissue homeostasis. Some soluble factors, such as TGFβ, potently modify the behavior of healthy stromal cells. A subpo
Externí odkaz:
https://doaj.org/article/8319198f0e46428e87b3865f27609b45
Autor:
Talia Velasco‐Hernandez, Juan L. Trincado, Meritxell Vinyoles, Adria Closa, Alba Martínez‐Moreno, Francisco Gutiérrez‐Agüera, Oscar Molina, Virginia C. Rodríguez‐Cortez, Pau Ximeno‐Parpal, Narcís Fernández‐Fuentes, Paolo Petazzi, Sergi Beneyto‐Calabuig, Lars Velten, Paola Romecin, Raquel Casquero, Fernando Abollo‐Jiménez, Rafael D. de laGuardia, Patricia Lorden, Alex Bataller, Hélène Lapillonne, Ronald W. Stam, Susana Vives, Montserrat Torrebadell, Jose L. Fuster, Clara Bueno, Jean‐Emmanuel Sarry, Eduardo Eyras, Holger Heyn, Pablo Menéndez
Publikováno v:
HemaSphere, Vol 8, Iss 2, Pp n/a-n/a (2024)
Abstract Relapse remains a major challenge in the clinical management of acute myeloid leukemia (AML) and is driven by rare therapy‐resistant leukemia stem cells (LSCs) that reside in specific bone marrow niches. Hypoxia signaling maintains cells i
Externí odkaz:
https://doaj.org/article/5cf2e9d9f3b0488ebf1aab0a7234b697
Autor:
Alicia Vachon, Grace E. Seo, Nishi H. Patel, Carla S. Coffin, Eric Marinier, Eduardo Eyras, Carla Osiowy
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
IntroductionSerum hepatitis B virus (HBV) RNA is a promising new biomarker to manage and predict clinical outcomes of chronic hepatitis B (CHB) infection. However, the HBV serum transcriptome within encapsidated particles, which is the biomarker anal
Externí odkaz:
https://doaj.org/article/5dc8392f76ea48b19e398a4bde44ae4f
Autor:
Ivan de la Rubia, Akanksha Srivastava, Wenjing Xue, Joel A. Indi, Silvia Carbonell-Sala, Julien Lagarde, M. Mar Albà, Eduardo Eyras
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-21 (2022)
Abstract Nanopore sequencing enables the efficient and unbiased measurement of transcriptomes. Current methods for transcript identification and quantification rely on mapping reads to a reference genome, which precludes the study of species with a p
Externí odkaz:
https://doaj.org/article/2aea7a73013a4bcfa785023e73ad47b8
Autor:
Alba Navarro-Romero, Lorena Galera-López, Paula Ortiz-Romero, Alberto Llorente-Ovejero, Lucía de los Reyes-Ramírez, Iker Bengoetxea de Tena, Anna Garcia-Elias, Aleksandra Mas-Stachurska, Marina Reixachs-Solé, Antoni Pastor, Rafael de la Torre, Rafael Maldonado, Begoña Benito, Eduardo Eyras, Rafael Rodríguez-Puertas, Victoria Campuzano, Andres Ozaita
Publikováno v:
eLife, Vol 11 (2022)
Williams–Beuren syndrome (WBS) is a rare genetic multisystemic disorder characterized by mild-to-moderate intellectual disability and hypersocial phenotype, while the most life-threatening features are cardiovascular abnormalities. Nowadays, there
Externí odkaz:
https://doaj.org/article/30bd7532970b48ce8dab47e31977a19e
Autor:
Zaka Wing-Sze Yuen, Akanksha Srivastava, Runa Daniel, Dennis McNevin, Cameron Jack, Eduardo Eyras
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Several existing algorithms predict the methylation of DNA using Nanopore sequencing signals, but it is unclear how they compare in performance. Here, the authors benchmark the performance of several such tools, and propose METEORE, a consensus tool
Externí odkaz:
https://doaj.org/article/08b6b5b4d12c45159aef5d1595b46fac
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Viral co-infections occur in COVID-19 patients, potentially impacting disease progression and severity. However, there is currently no dedicated method to identify viral co-infections in patient RNA-seq data. We developed PACIFIC, a deep-lea
Externí odkaz:
https://doaj.org/article/b82366e3d40b4510b6e44d39f34ef2d9
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Genes express multiple mRNA isoforms through alternative processing. Here the authors analyze ribosome profiling data with ORQAS (ORF quantification pipeline for alternative splicing) and report that 40–50% of the expressed mRNA isoforms are transl
Externí odkaz:
https://doaj.org/article/8300914fcd7944f19456d74ca9806c68
Autor:
Juan L Trincado, Marina Reixachs-Solé, Judith Pérez-Granado, Tim Fugmann, Ferran Sanz, Jun Yokota, Eduardo Eyras
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 9, p e1009411 (2021)
Immunotherapies provide effective treatments for previously untreatable tumors and identifying tumor-specific epitopes can help elucidate the molecular determinants of therapy response. Here, we describe a pipeline, ISOTOPE (ISOform-guided prediction
Externí odkaz:
https://doaj.org/article/18b91b59c3034de09c1d3b6bbc285879