Single cell genome amplification accelerates identification of the apratoxin biosynthetic pathway from a complex microbial assemblage.

Autor: Rashel V Grindberg, Thomas Ishoey, Dumitru Brinza, Eduardo Esquenazi, R Cameron Coates, Wei-ting Liu, Lena Gerwick, Pieter C Dorrestein, Pavel Pevzner, Roger Lasken, William H Gerwick

Publikováno v: PLoS ONE, Vol 6, Iss 4, p e18565 (2011)

Filamentous marine cyanobacteria are extraordinarily rich sources of structurally novel, biomedically relevant natural products. To understand their biosynthetic origins as well as produce increased supplies and analog molecules, access to the cluste

Externí odkaz: https://doaj.org/article/ab750730540e4b89a80c5d1e6195d2d8

Molecular Networking As a Drug Discovery, Drug Metabolism, and Precision Medicine Strategy

Autor: Oliver B. Vining, Eduardo Esquenazi, Michael J. Meehan, Robert A. Quinn, Louis-Félix Nothias, Pieter C. Dorrestein

Publikováno v: Trends in Pharmacological Sciences. 38:143-154

Molecular networking is a tandem mass spectrometry (MS/MS) data organizational approach that has been recently introduced in the drug discovery, metabolomics, and medical fields. The chemistry of molecules dictates how they will be fragmented by MS/M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ea30f64d4c33938289adc010e381ea
https://doi.org/10.1016/j.tips.2016.10.011

Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

Autor: Jingqui Dai, Alexey V. Melnik, Jenan J. Kharbush, Kenji L. Kurita, Robert A. Keyzers, Katrina M. Waters, Mario Sandoval-Calderón, Ajit Jadhav, Clifford A. Kapono, Charles B. Larson, Evgenia Glukhov, Danielle VanLeer, Daniel P. Demarque, Lars Jelsbak, Yi Zeng, Eve A. Granatosky, Kit Pogliano, Maryam Elfeki, Marcelino Gutiérrez, Jeramie D. Watrous, Katherine R. Duncan, Laura M. Sanchez, Jeremy Carver, Brendan M. Duggan, Thomas O. Metz, Julia A. Vorholt, Pep Charusanti, Paul Shinn, Nuno Bandeira, Pavel A. Pevzner, Amy C. Sims, Nobuhiro Koyama, David Gonzalez, Xueting Liu, Denise Brentan Silva, Venkat R. Macherla, Pieter C. Dorrestein, Andrew R. Johnson, Jörn Piel, Michael J. Meehan, Delphine Parrot, Jehad Almaliti, Don D. Nguyen, Louis-Félix Nothias, Wenyuan Shi, Max Crüsemann, Cristopher A. Boya P., Philip G. Williams, Erin E. Carlson, Ronnie G. Gavilan, Yao Peng, Roland D. Kersten, Jennifer E. Kyle, Bertrand Aigle, Yu-Liang Yang, Mingxun Wang, Amina Bouslimani, Lixin Zhang, Ram P. Neupane, Chih-Chuang Liaw, Tyler Peryea, Eric J. N. Helfrich, Kristian Fog Nielsen, Hans-Ulrich Humpf, Robert A. Quinn, Rolf Müller, Paul R. Jensen, Hailey Houson, Eduardo Esquenazi, Kathleen Dorrestein, Vanessa V. Phelan, Bernhard O. Palsson, Lisa Vuong, Cheng-Chih Hsu, Sophie Tomasi, Trent R. Northen, Laura A. Pace, Marc Litaudon, Samantha J. Mascuch, Chen Zhang, Maria Maansson, Ashley M. Sidebottom, Vinayak Agarwal, Ricardo Pianta Rodrigues da Silva, Ellis C. O’Neill, Tal Luzzatto-Knaan, Florian Ryffel, Oliver B. Vining, Andrés M. C. Rodríguez, Andreas Klitgaard, Enora Briand, Brian T. Murphy, Neha Garg, Norberto Peporine Lopes, Ralph S. Baric, William H. Gerwick, Pierre-Marie Allard, Daniel Torres-Mendoza, Jeffrey S. McLean, Stefan Jenkins, Lena Gerwick, Theodore Alexandrov, Roger G. Linington, Egle Pociute, Christian Sohlenkamp, Joshua R. Gurr, Matthew F. Traxler, Wei-Ting Liu, Rob Knight, Anne Lamsa, Anna Edlund, Bradley S. Moore, Prasad Phapale, Hosein Mohimani, Karin Kleigrewe, Charlotte Frydenlund Michelsen, Lucas Miranda Marques, Niclas Engene, Jean-Luc Wolfender, Thomas Hoffman, Rachel J. Dutton, Dac-Trung Nguyen, Paul D. Boudreau, Dimitrios J. Floros, Kerry L. McPhail, Carla Porto, Brian E. Sedio

Publikováno v: Nature Biotechnology
Nature Biotechnology, 2016, 34 (8), pp.828-837. ⟨10.1038/nbt.3597⟩
Nature Biotechnology, Vol. 34, No 8 (2016) pp. 828-837
Nature Biotechnology, Nature Publishing Group, 2016, 34 (8), pp.828-837. ⟨10.1038/nbt.3597⟩
Nature Biotechnology (1087-0156) (Nature Publishing Group), 2016-08, Vol. 34, N. 8, P. 828-837
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Wang, M, Carver, J J, Pevzner, P, Mohiman, H, Bandeira, N, Phelan, V V, Sanchez, L M, Garg, N, Watrous, J, Luzzatto-Knaa, T, Frydenlund Michelsen, C, Jelsbak, L, Månsson, M, Klitgaard, A & Nielsen, K F 2016, ' Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking ', Nature Biotechnology, vol. 34, no. 8, pp. 828-837 . https://doi.org/10.1038/nbt.3597

International audience; The potential of the diverse chemistries present in natural products (NP) for biotechnology and medicine remains untapped because NP databases are not searchable with raw data and the NP community has no way to share data othe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f2e3140b4f64a60719d91435998b61
https://doi.org/10.1038/nbt.3597

Significant Natural Product Biosynthetic Potential of Actinorhizal Symbionts of the Genus Frankia, as Revealed by Comparative Genomic and Proteomic Analyses

Autor: Jaclyn M. Winter, Kelle C. Freel, Wei-Ting Liu, Bradley S. Moore, Jane Y. Yang, Eduardo Esquenazi, Nicholas Beauchemin, Katherine N. Maloney, Markus Nett, Louis S. Tisa, Alessandra S. Eustáquio, Karla L. Malloy, William H. Gerwick, Erin A. Gontang, Andrew W. Schultz, Micheal C. Wilson, Thomas L. Simmons, Alejandra Prieto-Davó, Kevin Penn, Sara Weitz, Carla S. Jones, Benjamin R. Clark, Joshawna K. Nunnery, Pieter C. Dorrestein, Adam C. Jones, Lena Gerwick, Todd L. Capson, David Gonzalez, Daniel W. Udwary

Publikováno v: Applied and Environmental Microbiology. 77:3617-3625

Bacteria of the genus Frankia are mycelium-forming actinomycetes that are found as nitrogen-fixing facultative symbionts of actinorhizal plants. Although soil-dwelling actinomycetes are well-known producers of bioactive compounds, the genus Frankia h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be5b0f9ea8c85647eb6346bcd7e1aba3
https://doi.org/10.1128/aem.00038-11

Underestimated biodiversity as a major explanation for the perceived rich secondary metabolite capacity of the cyanobacterial genusLyngbya

Autor: Erin C. Rottacker, Eduardo Esquenazi, Pieter C. Dorrestein, Niclas Engene, William H. Gerwick, Mark H. Ellisman, Hyukjae Choi

Publikováno v: Environmental Microbiology. 13:1601-1610

Marine cyanobacteria are prolific producers of bioactive secondary metabolites responsible for harmful algal blooms as well as rich sources of promising biomedical lead compounds. The current study focused on obtaining a clearer understanding of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::176e6ab648c8fadac053cf62a2fe501f
https://doi.org/10.1111/j.1462-2920.2011.02472.x