Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Eduardo D. Gigante"'
Autor:
Julien Ferent, Sandii Constable, Eduardo D. Gigante, Patricia T. Yam, Laura E. Mariani, Emilie Legué, Karel F. Liem, Jr., Tamara Caspary, Frédéric Charron
Publikováno v:
Cell Reports, Vol 29, Iss 11, Pp 3356-3366.e3 (2019)
Summary: The small GTPase Arl13b is enriched in primary cilia and regulates Sonic hedgehog (Shh) signaling. During neural development, Shh controls patterning and proliferation through a canonical, transcription-dependent pathway that requires the pr
Externí odkaz:
https://doaj.org/article/9a2d657e0e474c2d9ac61327fe688811
Publikováno v:
eLife, Vol 9 (2020)
ARL13B is a regulatory GTPase highly enriched in cilia. Complete loss of Arl13b disrupts cilia architecture, protein trafficking and Sonic hedgehog signaling. To determine whether ARL13B is required within cilia, we knocked in a cilia-excluded varian
Externí odkaz:
https://doaj.org/article/9ebabb87e0c3470a939db05e112ec9ae
Publikováno v:
bioRxiv
ARL13B is a small GTPase enriched in cilia. Deletion ofArl13bin mouse kidney results in renal cysts and an associated absence of primary cilia. Similarly, ablation of cilia leads to kidney cysts. To investigate whether ARL13B functions from within ci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::405e38498842afdc7147111a36708dbe
https://europepmc.org/articles/PMC9934666/
https://europepmc.org/articles/PMC9934666/
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158885 (2016)
Electrical stimulation of the lateral hypothalamus can motivate feeding or can serve as a reward in its own right. It remains unclear whether the same or independent but anatomically overlapping circuitries mediate the two effects. Electrical stimula
Externí odkaz:
https://doaj.org/article/63a3ccd5d39b49d5b51fbd4c93e284a5
Autor:
Uwe Wolfrum, Tamara Caspary, Eduardo D. Gigante, Richard A. Kahn, Rachel E. Turn, Joshua Linnert
Publikováno v:
Molecular Biology of the Cell
ELMOD2 is a GTPase activating protein (GAP) with uniquely broad specificity for ARF family GTPases. We previously showed that it acts with ARL2 in mitochondrial fusion and microtubule stability and with ARF6 during cytokinesis. Mouse embryonic fibrob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f5e9ee062f0a30b00f4d7afcddde8f
https://pubmed.ncbi.nlm.nih.gov/33596093
https://pubmed.ncbi.nlm.nih.gov/33596093
Autor:
Tamara Caspary, Eduardo D. Gigante
Publikováno v:
The Journal of Cell Biology
Shinde et al. find that activation of G protein–coupled receptors (GPCRs) inside cilia triggers formation of ubiquitin chains onto the receptors via β-arrestin and that ubiquitin chains commit the GPCRs for exit from cilia.
Regulated traffick
Regulated traffick
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a6241436ab0700ff290b2439ca09824
https://pubmed.ncbi.nlm.nih.gov/33185668
https://pubmed.ncbi.nlm.nih.gov/33185668
Autor:
Tamara Caspary, Eduardo D. Gigante
Publikováno v:
Wiley Interdiscip Rev Dev Biol
Cilia are microtubule-based, cell-surface projections whose machinery is evolutionarily conserved. In vertebrates, cilia are observed on almost every cell type and are either motile or immotile. Immotile sensory, or primary cilia, are responsive to e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf1d438b19b048c93ce2aa444bdcfaa
https://doi.org/10.1002/wdev.377
https://doi.org/10.1002/wdev.377
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
ARL13B is a regulatory GTPase highly enriched in cilia. Complete loss ofArl13bdisrupts cilia architecture, protein trafficking and Sonic hedgehog signaling. To determine whether ARL13B is required within cilia, we knocked in a cilia-excluded variant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd56cf2d87bcfbc7b992b85009124d18