Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Eduardo Cepeda-Cañedo"'
Autor:
Kyle Lewis, Rachel La Selva, Elias Maldonado, Matthew G. Annis, Ouafa Najyb, Eduardo Cepeda Cañedo, Stephanie Totten, Steven Hébert, Valérie Sabourin, Caitlynn Mirabelli, Emma Ciccolini, Camille Lehuédé, Luc Choinière, Mariana Russo, Daina Avizonis, Morag Park, Julie St-Pierre, Claudia L. Kleinman, Peter M. Siegel, Josie Ursini-Siegel
Publikováno v:
Redox Biology, Vol 70, Iss , Pp 103028- (2024)
Significant efforts have focused on identifying targetable genetic drivers that support the growth of solid tumors and/or increase metastatic ability. During tumor development and progression to metastatic disease, physiological and pharmacological s
Externí odkaz:
https://doaj.org/article/8bcb1cc7a7684f09b3d926e68c5a0e4c
Autor:
Stephanie P. Totten, Young Kyuen Im, Eduardo Cepeda Cañedo, Ouafa Najyb, Alice Nguyen, Steven Hébert, Ryuhjin Ahn, Kyle Lewis, Benjamin Lebeau, Rachel La Selva, Valérie Sabourin, Constanza Martínez, Paul Savage, Hellen Kuasne, Daina Avizonis, Nancy Santos Martínez, Catherine Chabot, Adriana Aguilar-Mahecha, Marie-Line Goulet, Matthew Dankner, Michael Witcher, Kevin Petrecca, Mark Basik, Michael Pollak, Ivan Topisirovic, Rongtuan Lin, Peter M. Siegel, Claudia L. Kleinman, Morag Park, Julie St-Pierre, Josie Ursini-Siegel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Complex I inhibition induces oxidative stress leading to cancer cell cytotoxicity. Here, the authors show, in breast cancer models, that inflammatory mediators can potentiate complex I inhibitor phenformin cytotoxicity through STAT1-mediated downregu
Externí odkaz:
https://doaj.org/article/e78e979f7f9a43d280222791ea6273df
Autor:
Eduardo Cepeda Cañedo, Stephanie Totten, Ryuhjin Ahn, Paul Savage, Deanna MacNeil, Jesse Hudson, Chantal Autexier, Genevieve Deblois, Morag Park, Michael Witcher, Josie Ursini-Siegel
Publikováno v:
JCI Insight, Vol 6, Iss 4 (2021)
Triple-negative breast cancers (TNBCs) lack effective targeted therapies, and cytotoxic chemotherapies remain the standard of care for this subtype. Owing to their increased genomic instability, poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi)
Externí odkaz:
https://doaj.org/article/96aa4977e46346acb779cdd5bbcf3cf3
Autor:
Josie Ursini-Siegel, William J. Muller, Claudia L. Kleinman, Young Kyuen Im, Eduardo Cepeda Cañedo, Steven Hébert, Valerie Sabourin, Harvey W. Smith, Ryuhjin Ahn, Jacqueline R. Ha
Supplementary Figure Legends, Figures 1 - 7 from Integration of Distinct ShcA Signaling Complexes Promotes Breast Tumor Growth and Tyrosine Kinase Inhibitor Resistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ee845bd9026f86008b686e96ad6b99
https://doi.org/10.1158/1541-7786.22515571.v1
https://doi.org/10.1158/1541-7786.22515571.v1
Autor:
Josie Ursini-Siegel, William J. Muller, Claudia L. Kleinman, Young Kyuen Im, Eduardo Cepeda Cañedo, Steven Hébert, Valerie Sabourin, Harvey W. Smith, Ryuhjin Ahn, Jacqueline R. Ha
The commonality between most phospho-tyrosine signaling networks is their shared use of adaptor proteins to transduce mitogenic signals. ShcA (SHC1) is one such adaptor protein that employs two phospho-tyrosine binding domains (PTB and SH2) and key p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a1b890a55ac69f6fffa4d137ea60e32
https://doi.org/10.1158/1541-7786.c.6541126
https://doi.org/10.1158/1541-7786.c.6541126
Autor:
Josie Ursini-Siegel, William J. Muller, Claudia L. Kleinman, Young Kyuen Im, Eduardo Cepeda Cañedo, Steven Hébert, Valerie Sabourin, Harvey W. Smith, Ryuhjin Ahn, Jacqueline R. Ha
Supplementary Table 1: List of differentially expressed genes comprising the ShcA-PTBMUT-like gene signature (GEO GSE41718) used for Figure S7. Supplementary Table 2: Antibodies used for immunoblot analysis (referred to in the supplementary methods).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::131531661948e8598188b2837b8798c6
https://doi.org/10.1158/1541-7786.22515565.v1
https://doi.org/10.1158/1541-7786.22515565.v1
Autor:
Josie Ursini-Siegel, William J. Muller, Claudia L. Kleinman, Young Kyuen Im, Eduardo Cepeda Cañedo, Steven Hébert, Valerie Sabourin, Harvey W. Smith, Ryuhjin Ahn, Jacqueline R. Ha
Experimental methods for Crispr/Cas9 genomic editing, BioID, immunoblot analysis, immunoprecipitation analysis, immunohistochemistry and bioinformatics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::001c339cde24411ea5fb922f61d553f7
https://doi.org/10.1158/1541-7786.22515568
https://doi.org/10.1158/1541-7786.22515568
Autor:
Steven Hébert, Ryuhjin Ahn, Ivan Topisirovic, Matthew Dankner, Daina Avizonis, Kyle Lewis, Julie St-Pierre, Marie-Line Goulet, Josie Ursini-Siegel, Eduardo Cepeda Cañedo, Mark Basik, Alice Nguyen, Kevin Petrecca, Valerie Sabourin, Nancy Santos Martínez, Constanza Martinez, Benjamin Lebeau, Rongtuan Lin, Morag Park, Ouafa Najyb, Adriana Aguilar-Mahecha, Michael Witcher, Peter M. Siegel, Paul Savage, Catherine Chabot, Rachel La Selva, Young Kyuen Im, Claudia L. Kleinman, Hellen Kuasne, Stephanie Totten, Michael Pollak
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Nature Communications
Nature Communications
Bioenergetic perturbations driving neoplastic growth increase the production of reactive oxygen species (ROS), requiring a compensatory increase in ROS scavengers to limit oxidative stress. Intervention strategies that simultaneously induce energetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5efb52addcc93ac7072fb39e5c81282a
https://doaj.org/article/e78e979f7f9a43d280222791ea6273df
https://doaj.org/article/e78e979f7f9a43d280222791ea6273df
Autor:
Josie Ursini-Siegel, Morag Park, Paul Savage, Jesse Hudson, Geneviève Deblois, Chantal Autexier, Deanna Elise MacNeil, Eduardo Cepeda Cañedo, Ryuhjin Ahn, Stephanie Totten, Michael Witcher
Publikováno v:
JCI Insight
JCI Insight, Vol 6, Iss 4 (2021)
JCI Insight, Vol 6, Iss 4 (2021)
Triple-negative breast cancers (TNBCs) lack effective targeted therapies, and cytotoxic chemotherapies remain the standard of care for this subtype. Owing to their increased genomic instability, poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811f95d98d0b68f2f57cd15f58ebb37b
https://pubmed.ncbi.nlm.nih.gov/33470989
https://pubmed.ncbi.nlm.nih.gov/33470989
Autor:
Harvey W. Smith, Valerie Sabourin, Jacqueline R. Ha, Josie Ursini-Siegel, Claudia L. Kleinman, Ryuhjin Ahn, Steven Hébert, Young Kyuen Im, Eduardo Cepeda Cañedo, William J. Muller
Publikováno v:
Molecular Cancer Research. 16:894-908
The commonality between most phospho-tyrosine signaling networks is their shared use of adaptor proteins to transduce mitogenic signals. ShcA (SHC1) is one such adaptor protein that employs two phospho-tyrosine binding domains (PTB and SH2) and key p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4f58132846de8d86b4f2c68f476962b
https://doi.org/10.1158/1541-7786.mcr-17-0623
https://doi.org/10.1158/1541-7786.mcr-17-0623