Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Eduardo Caleiras"'
Autor:
Ana Belén Plata-Gómez, Lucía de Prado-Rivas, Alba Sanz, Nerea Deleyto-Seldas, Fernando García, Celia de la Calle Arregui, Camila Silva, Eduardo Caleiras, Osvaldo Graña-Castro, Elena Piñeiro-Yáñez, Joseph Krebs, Luis Leiva-Vega, Javier Muñoz, Ajay Jain, Guadalupe Sabio, Alejo Efeyan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The metabolic functions of the liver are spatially organized in a phenomenon called zonation, linked to the differential exposure of portal and central hepatocytes to nutrient-rich blood. The mTORC1 signaling pathway controls cellular metabo
Externí odkaz:
https://doaj.org/article/4772ae75e9d74a97a90d1058448dea3e
Autor:
Alberto Hernández-Barranco, Vanesa Santos, Marina S. Mazariegos, Eduardo Caleiras, Laura Nogués, Frédéric Mourcin, Simon Léonard, Christelle Oblet, Steve Genebrier, Delphine Rossille, Alberto Benguría, Alba Sanz, Enrique Vázquez, Ana Dopazo, Alejo Efeyan, Ana Ortega-Molina, Michel Cogne, Karin Tarte, Héctor Peinado
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113705- (2024)
Summary: Nerve growth factor receptor (NGFR) is expressed by follicular dendritic cells (FDCs). However, the role of NGFR in the humoral response is not well defined. Here, we study the effect of Ngfr loss on lymph node organization and function, dem
Externí odkaz:
https://doaj.org/article/633cda8ce4e244e3af309d6246a7a4de
Autor:
Nuria G. Martínez-Illescas, Silvia Leal, Patricia González, Osvaldo Graña-Castro, Juan José Muñoz-Oliveira, Alfonso Cortés-Peña, María Gómez-Gil, Zaira Vega, Verónica Neva, Andrea Romero, Miguel Quintela-Fandino, Eva Ciruelos, Consuelo Sanz, Sofía Aragón, Leisy Sotolongo, Sara Jiménez, Eduardo Caleiras, Francisca Mulero, Cristina Sánchez, Marcos Malumbres, María Salazar-Roa
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-21 (2023)
Abstract A hallmark of many malignant tumors is dedifferentiated (immature) cells bearing slight or no resemblance to the normal cells from which the cancer originated. Tumor dedifferentiated cells exhibit a higher capacity to survive to chemo and ra
Externí odkaz:
https://doaj.org/article/563051e71f9b4c11bb12717d56311f38
Autor:
Sara Mellid, Fernando García, Luis Javier Leandro‐García, Alberto Díaz‐Talavera, Ángel Mario Martínez‐Montes, Eduardo Gil, Bruna Calsina, María Monteagudo, Rocío Letón, Juan María Roldán‐Romero, María Santos, Javier Lanillos, Carlos Valdivia, Natalia Martínez‐Puente, Javier deNicolás‐Hernández, Scherezade Jiménez, Manuel Pérez‐Martínez, Emiliano Honrado, Javier Coloma, Ana Cerezo, Clara María Santiveri, Manel Esteller, Ramón Campos‐Olivas, Eduardo Caleiras, Cristina Montero‐Conde, Cristina Rodríguez‐Antona, Javier Muñoz, Mercedes Robledo, Alberto Cascón
Publikováno v:
Cancer Communications, Vol 43, Iss 7, Pp 838-843 (2023)
Externí odkaz:
https://doaj.org/article/7a4592683fca443f99a97448735a8528
Autor:
Bruna Calsina, Elena Piñeiro-Yáñez, Ángel M. Martínez-Montes, Eduardo Caleiras, Ángel Fernández-Sanromán, María Monteagudo, Rafael Torres-Pérez, Coral Fustero-Torre, Marta Pulgarín-Alfaro, Eduardo Gil, Rocío Letón, Scherezade Jiménez, Santiago García-Martín, Maria Carmen Martin, Juan María Roldán-Romero, Javier Lanillos, Sara Mellid, María Santos, Alberto Díaz-Talavera, Ángeles Rubio, Patricia González, Barbara Hernando, Nicole Bechmann, Margo Dona, María Calatayud, Sonsoles Guadalix, Cristina Álvarez-Escolá, Rita M. Regojo, Javier Aller, Maria Isabel Del Olmo-Garcia, Adrià López-Fernández, Stephanie M. J. Fliedner, Elena Rapizzi, Martin Fassnacht, Felix Beuschlein, Marcus Quinkler, Rodrigo A. Toledo, Massimo Mannelli, Henri J. Timmers, Graeme Eisenhofer, Sandra Rodríguez-Perales, Orlando Domínguez, Geoffrey Macintyre, Maria Currás-Freixes, Cristina Rodríguez-Antona, Alberto Cascón, Luis J. Leandro-García, Cristina Montero-Conde, Giovanna Roncador, Juan Fernando García-García, Karel Pacak, Fátima Al-Shahrour, Mercedes Robledo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
The molecular mechanisms underlying metastasis in pheochromocytoma/paraganglioma (mPPGL) remain to be explored. Here, the authors perform genomic and immunogenomic profiling of mPPGL tumors and suggest potential biomarkers for risk of metastasis and
Externí odkaz:
https://doaj.org/article/69b48437dc7349d2ae46afb0ace70885
Autor:
Pedro Aguilar Garrido, Maria Velasco Estevez, Miguel Ángel Navarro Aguadero, María Hernández Sánchez, Prerna Malaney, Marisa Hornbaker, Xiaorui Zhang, Marta Ibañez Navarro, Alejandra Ortiz-Ruiz, Álvaro Otero-Sobrino, Diego Megías, Manuel Pérez, Jesús Gómez, Gadea Mata, Orlando Dominguez, Osvaldo Grana, Eduardo Caleiras, Marta Isasa, Paloma Jimena de Andrés, Sandra Rodriguez, Raúl Torres, Oleksandra Sirozh, Vanesa Lafarga, Joaquín Martínez-Lopez, Sean Post, Miguel Gallardo
Publikováno v:
HemaSphere, Vol 7, p e8819188 (2023)
Externí odkaz:
https://doaj.org/article/31825dcb3d8a4b67a90a4ac36218cf8e
Autor:
Marina Salmón, Ruth Álvarez-Díaz, Coral Fustero-Torre, Oksana Brehey, Carmen G. Lechuga, Manuel Sanclemente, Fernando Fernández-García, Alejandra López-García, María Carmen Martín-Guijarro, Sandra Rodríguez-Perales, Emily Bousquet-Mur, Lucía Morales-Cacho, Francisca Mulero, Fátima Al-Shahrour, Lola Martínez, Orlando Domínguez, Eduardo Caleiras, Sagrario Ortega, Carmen Guerra, Monica Musteanu, Matthias Drosten, Mariano Barbacid
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 7 (2023)
KRASG12C inhibitors have revolutionized the clinical management of patients with KRASG12C-mutant lung adenocarcinoma. However, patient exposure to these inhibitors leads to the rapid onset of resistance. In this study, we have used genetically engine
Externí odkaz:
https://doaj.org/article/a51ce49b33904d3e80b5fe3757365959
Autor:
Maria-Luisa del Rio, Carla Yago-Diez de Juan, Giovanna Roncador, Eduardo Caleiras, Ramón Álvarez-Esteban, José Antonio Pérez-Simón, Jose-Ignacio Rodriguez-Barbosa
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionA high frequency of mutations affecting the gene encoding Herpes Virus Entry Mediator (HVEM, TNFRSF14) is a common clinical finding in a wide variety of human tumors, including those of hematological origin.MethodsWe have addressed how HV
Externí odkaz:
https://doaj.org/article/d45f1aac1da2426b84b5c0a30178393d
Autor:
Sara Mellid, Eduardo Gil, Rocío Letón, Eduardo Caleiras, Emiliano Honrado, Susan Richter, Nuria Palacios, Marcos Lahera, Juan C. Galofré, Adriá López-Fernández, Maria Calatayud, Aura D. Herrera-Martínez, María A. Galvez, Xavier Matias-Guiu, Milagros Balbín, Esther Korpershoek, Eugénie S. Lim, Francesca Maletta, Sofia Lider, Stephanie M. J. Fliedner, Nicole Bechmann, Graeme Eisenhofer, Letizia Canu, Elena Rapizzi, Irina Bancos, Mercedes Robledo, Alberto Cascón
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2023)
IntroductionThe percentage of patients diagnosed with pheochromocytoma and paraganglioma (altogether PPGL) carrying known germline mutations in one of the over fifteen susceptibility genes identified to date has dramatically increased during the last
Externí odkaz:
https://doaj.org/article/c4c5fc8413084893a0bdc6df97e44790
Autor:
Celia de la Calle Arregui, Ana Belén Plata-Gómez, Nerea Deleyto-Seldas, Fernando García, Ana Ortega-Molina, Julio Abril-Garrido, Elena Rodriguez, Ivan Nemazanyy, Laura Tribouillard, Alba de Martino, Eduardo Caleiras, Ramón Campos-Olivas, Francisca Mulero, Mathieu Laplante, Javier Muñoz, Mario Pende, Guadalupe Sabio, David M. Sabatini, Alejo Efeyan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
The mechanistic target of rapamycin complex 1 (mTORC1) integrates nutrient and hormonal signals to control metabolism. Here the authors investigate the effects of constitutive nutrient signaling through genetic activation of RagA in adult mice and sh
Externí odkaz:
https://doaj.org/article/ede1c5d31c18497daed3a08d29f4a91b