Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Eduardo Bonavita"'
Autor:
Aurora Gazzillo, Camilla Volponi, Cristiana Soldani, Michela Anna Polidoro, Barbara Franceschini, Ana Lleo, Eduardo Bonavita, Matteo Donadon
Publikováno v:
Biomedicines, Vol 12, Iss 1, p 26 (2023)
Liver cancer represents the fourth leading cause of cancer-associated death worldwide. The heterogeneity of its tumor microenvironment (TME) is a major contributing factor of metastasis, relapse, and drug resistance. Regrettably, late diagnosis makes
Externí odkaz:
https://doaj.org/article/96048340d86a4c5f9e56cebe65104a6f
Autor:
Silvia Carnevale, Irene Di Ceglie, Giovanna Grieco, Anna Rigatelli, Eduardo Bonavita, Sebastien Jaillon
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Neutrophils are the most abundant circulating leukocytes in humans and the first immune cells recruited at the site of inflammation. Classically perceived as short-lived effector cells with limited plasticity and diversity, neutrophils are now recogn
Externí odkaz:
https://doaj.org/article/77793479f7014c0987454c9f82c594dc
Autor:
Charlotte R. Bell, Victoria S. Pelly, Agrin Moeini, Shih-Chieh Chiang, Eimear Flanagan, Christian P. Bromley, Christopher Clark, Charles H. Earnshaw, Maria A. Koufaki, Eduardo Bonavita, Santiago Zelenay
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
COX-2-mediated prostaglandin E2 (PGE2) release from dying cancer cells contributes to cytotoxic therapy resistance. Here the authors show that cytotoxic drugs induce PGE2 release only in cancer cells with basal COX-2 activity and that pharmacological
Externí odkaz:
https://doaj.org/article/2367c05eefed45eabfb5cebec3bd1bde
Publikováno v:
Cancers, Vol 14, Iss 24, p 6151 (2022)
HCC, the most prevalent form of primary liver cancer, is prototypically an inflammation-driven cancer developing after years of inflammatory insults. Consequently, the hepatic microenvironment is a site of complex immunological activities. Moreover,
Externí odkaz:
https://doaj.org/article/adfae2d311e54eab9762561f01c1dacd
Autor:
Santiago Zelenay, Daniela S. Thommen, Ton N. Schumacher, Claus Jørgensen, Shih-Chieh Chiang, Eimear Flanagan, Christian P. Bromley, Antonia Banyard, Adrian Blanco-Gomez, Colin Hutton, Charlotte R. Bell, Eduardo Bonavita, Lisanne M. Roelofsen, Agrin Moeini, Victoria S. Pelly
Table S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017a3c40264b8e2f69612f9eb8e7c603
https://doi.org/10.1158/2159-8290.22539473
https://doi.org/10.1158/2159-8290.22539473
Autor:
Santiago Zelenay, Daniela S. Thommen, Ton N. Schumacher, Claus Jørgensen, Shih-Chieh Chiang, Eimear Flanagan, Christian P. Bromley, Antonia Banyard, Adrian Blanco-Gomez, Colin Hutton, Charlotte R. Bell, Eduardo Bonavita, Lisanne M. Roelofsen, Agrin Moeini, Victoria S. Pelly
Identifying strategies to improve the efficacy of immune checkpoint blockade (ICB) remains a major clinical need. Here, we show that therapeutically targeting the COX2/PGE2/EP2-4 pathway with widely used nonsteroidal and steroidal anti-inflammatory d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8984675ccc2ee02aad006ca4186bf241
https://doi.org/10.1158/2159-8290.c.6549104.v1
https://doi.org/10.1158/2159-8290.c.6549104.v1
Autor:
Santiago Zelenay, Daniela S. Thommen, Ton N. Schumacher, Claus Jørgensen, Shih-Chieh Chiang, Eimear Flanagan, Christian P. Bromley, Antonia Banyard, Adrian Blanco-Gomez, Colin Hutton, Charlotte R. Bell, Eduardo Bonavita, Lisanne M. Roelofsen, Agrin Moeini, Victoria S. Pelly
Supplementary Figures and supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::368b85f9b253cc646efd59ce772aa109
https://doi.org/10.1158/2159-8290.22539494.v1
https://doi.org/10.1158/2159-8290.22539494.v1
Autor:
Veronica Vella, Rosamaria Lappano, Eduardo Bonavita, Marcello Maggiolini, Robert Bryan Clarke, Antonino Belfiore, Ernestina Marianna De Francesco
Publikováno v:
Endocrine Reviews.
In metabolic conditions such as obesity and diabetes, which are associated with deregulated signaling of the insulin/insulin-like growth factor system (IIGFs), inflammation plays a dominant role. In cancer, IIGFs is implicated in disease progression,
Autor:
Veronica Vella, Ernestina Marianna De Francesco, Eduardo Bonavita, Rosamaria Lappano, Antonino Belfiore
Publikováno v:
Trends in endocrinology and metabolism: TEM. 33(8)
Type I interferons (IFN-Is) are prototypical inflammatory cytokines produced in response to stress. IFN-Is have a critical role in antitumor immunity by driving the activation of leukocytes and favoring the elimination of malignant cells. However, IF
Autor:
Charlotte R, Bell, Victoria S, Pelly, Agrin, Moeini, Shih-Chieh, Chiang, Eimear, Flanagan, Christian P, Bromley, Christopher, Clark, Charles H, Earnshaw, Maria A, Koufaki, Eduardo, Bonavita, Santiago, Zelenay
Publikováno v:
Nature communications. 13(1)
Cytotoxic therapies, besides directly inducing cancer cell death, can stimulate immune-dependent tumor growth control or paradoxically accelerate tumor progression. The underlying mechanisms dictating these opposing outcomes are poorly defined. Here,