Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Eduardo Balsa"'
Autor:
Lucia del Prado, Myriam Jaraíz-Rodríguez, Mauro Agro, Marcos Zamora-Dorta, Natalia Azpiazu, Manuel Calleja, Mario Lopez-Manzaneda, Jaime de Juan-Sanz, Alba Fernández-Rodrigo, José A. Esteban, Mònica Girona, Albert Quintana, Eduardo Balsa
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Deficiencies in the electron transport chain (ETC) lead to mitochondrial diseases. While mutations are distributed across the organism, cell and tissue sensitivity to ETC disruption varies, and the molecular mechanisms underlying this variab
Externí odkaz:
https://doaj.org/article/b2fa9d29c6fd4d769164d81519607546
Publikováno v:
Neurobiology of Disease, Vol 188, Iss , Pp 106327- (2023)
The brain is a highly metabolic organ, composed of multiple cell classes, that controls crucial functions of the body. Although neurons have traditionally been the main protagonist, astrocytes have gained significant attention over the last decade. I
Externí odkaz:
https://doaj.org/article/faad17e5e60f4ef2b218436634ae70e8
Autor:
Eduardo Balsa, Elizabeth A. Perry, Christopher F. Bennett, Mark Jedrychowski, Steven P. Gygi, John G. Doench, Pere Puigserver
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Mitochondrial oxidative phosphorylation produces ATP and is an important source for cellular energy equivalents. Here the authors perform a cell-based screen to identify genes that alleviate perturbed mitochondrial complex I function and identify mal
Externí odkaz:
https://doaj.org/article/6b5c34283bc544b78083839339684cb7
Autor:
Ines Soro-Arnaiz, Qilong Oscar Yang Li, Mar Torres-Capelli, Florinda Meléndez-Rodríguez, Sónia Veiga, Koen Veys, David Sebastian, Ainara Elorza, Daniel Tello, Pablo Hernansanz-Agustín, Sara Cogliati, Jose Maria Moreno-Navarrete, Eduardo Balsa, Esther Fuertes, Eduardo Romanos, Antonio Martínez-Ruiz, Jose Antonio Enriquez, Jose Manuel Fernandez-Real, Antonio Zorzano, Katrien De Bock, Julián Aragonés
Publikováno v:
Cell Reports, Vol 16, Iss 11, Pp 2991-3002 (2016)
Aging is associated with progressive white adipose tissue (WAT) enlargement initiated early in life, but the molecular mechanisms involved remain unknown. Here we show that mitochondrial complex IV (CIV) activity and assembly are already repressed in
Externí odkaz:
https://doaj.org/article/ec5bffb74faf4884a7b206fc053bc329
Autor:
Marta Miró-Murillo, Ainara Elorza, Inés Soro-Arnáiz, Lucas Albacete-Albacete, Angel Ordoñez, Eduardo Balsa, Alicia Vara-Vega, Silvia Vázquez, Esther Fuertes, Carmen Fernández-Criado, Manuel O Landázuri, Julián Aragonés
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22589 (2011)
Von Hippel Lindau (Vhl) gene inactivation results in embryonic lethality. The consequences of its inactivation in adult mice, and of the ensuing activation of the hypoxia-inducible factors (HIFs), have been explored mainly in a tissue-specific manner
Externí odkaz:
https://doaj.org/article/c382b1ecde1f4a379a4a40483a6f2a85
Autor:
Mark P. Jedrychowski, Pedro Latorre-Muro, Christopher F. Bennett, Kamar Reda, Steven P. Gygi, Elizabeth A. Perry, Richard Porter Ladley, Katherine E. O’Malley, Chi Luo, Eduardo Balsa, Andrew G. Myers, Peter M. Wright, Pere Puigserver
Publikováno v:
Nature metabolism
Mitochondrial diseases (MDs) are a heterogeneous group of disorders resulting from mutations in nuclear or mitochondrial DNA genes encoding mitochondrial proteins1,2. MDs cause pathologies with severe tissue damage and ultimately death3,4. There are
Autor:
Pere Puigserver, Elizabeth A. Perry, Clint D.J. Tavares, Francisca Vazquez, Chi Luo, Jiaxin Liang, Hans R. Widlund, Eduardo Balsa
Publikováno v:
J Clin Invest
Oncogene-targeted and immune checkpoint therapies have revolutionized the clinical management of malignant melanoma and now offer hope to patients with advanced disease. Intimately connected to patients' overall clinical risk is whether the initial p
Autor:
Elizabeth A. Perry, Steven P. Gygi, Christopher L. Riley, Mark P. Jedrychowski, Pedro Latorre-Muro, Christopher F. Bennett, Katherine E. O’Malley, Eduardo Balsa, Pere Puigserver, Chi Luo
Publikováno v:
Nature chemical biology
The protein complexes of the mitochondrial electron transport chain exist in isolation and in higher order assemblies termed supercomplexes (SCs) or respirasomes (SC I+III2+IV). The association of complexes I, III and IV into the respirasome is regul
Autor:
Christopher F. Bennett, Steven P. Gygi, Elizabeth A. Perry, Pere Puigserver, John G. Doench, Eduardo Balsa, Mark P. Jedrychowski
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
Nature Communications
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
Nature Communications
Biblos-e Archivo. Repositorio Institucional de la UAM
Electron transport chain (ETC) defects occurring from mitochondrial disease mutations compromise ATP synthesis and render cells vulnerable to nutrient and oxidative stress conditions. This bioenergetic failure is thought to underlie pathologies assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95f128f878290842de9ec12cc621065
http://hdl.handle.net/10261/222158
http://hdl.handle.net/10261/222158
Autor:
Ajith J. Thomas, Steven P. Gygi, Mark P. Jedrychowski, Eduardo Balsa, Hans R. Widlund, Pere Puigserver, Chi Luo, Maximilian Hatting
Publikováno v:
Molecular Cancer Research. 15:1366-1375
The uncontrolled growth of tumors provides metabolic dependencies that can be harnessed for therapeutic benefit. Although tumor cells exhibit these increased metabolic demands due to their rapid proliferation, these metabolic processes are general to