Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Eduardo A, Albornoz"'
Autor:
Ariel Isaacs, Alberto A. Amarilla, Julio Aguado, Naphak Modhiran, Eduardo A. Albornoz, Alireza A. Baradar, Christopher L. D. McMillan, Jovin J. Y. Choo, Adi Idris, Aroon Supramaniam, Nigel A. J. McMillan, David A. Muller, Paul R. Young, Trent M. Woodruff, Ernst J. Wolvetang, Keith J. Chappell, Daniel Watterson
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Since the start of the COVID-19 pandemic, multiple waves of SARS-CoV-2 variants have emerged. Of particular concern is the omicron variant, which harbors 28 mutations in the spike glycoprotein receptor binding and N-terminal domains relative to the a
Externí odkaz:
https://doaj.org/article/4cb5d30fc1704d60b97006877192104a
Autor:
Martin W Lo, Alberto A Amarilla, John D Lee, Eduardo A Albornoz, Naphak Modhiran, Richard J Clark, Vito Ferro, Mohit Chhabra, Alexander A Khromykh, Daniel Watterson, Trent M Woodruff
Publikováno v:
Clinical & Translational Immunology, Vol 11, Iss 8, Pp n/a-n/a (2022)
Abstract Objectives To determine whether SARS‐CoV‐2 can trigger complement activation, the pathways that are involved and the functional significance of the resultant effect. Methods SARS‐CoV‐2 was inoculated into a human lepirudin‐anticoag
Externí odkaz:
https://doaj.org/article/fce3333fc3fd462e95eb7a2ae93b9833
Autor:
Eduardo A. Albornoz, Richard Gordon, Vinod Kumar, Avril A. B. Robertson, Kate Schroder, Trent M. Woodruff
Publikováno v:
Science Translational Medicine. 15
We have replicated our original finding of elevated cleaved caspase-1 in mouse brains and neuroprotection by an NLRP3 inflammasome inhibitor in two mouse models of Parkinson’s disease.
Autor:
Eduardo A. Albornoz, Alberto A. Amarilla, Naphak Modhiran, Sandra Parker, Xaria X. Li, Danushka K. Wijesundara, Julio Aguado, Adriana Pliego Zamora, Christopher L. D. McMillan, Benjamin Liang, Nias Y. G. Peng, Julian D. J. Sng, Fatema Tuj Saima, Jenny N. Fung, John D. Lee, Devina Paramitha, Rhys Parry, Michael S. Avumegah, Ariel Isaacs, Martin W. Lo, Zaray Miranda-Chacon, Daniella Bradshaw, Constanza Salinas-Rebolledo, Niwanthi W. Rajapakse, Ernst J. Wolvetang, Trent P. Munro, Alejandro Rojas-Fernandez, Paul R. Young, Katryn J. Stacey, Alexander A. Khromykh, Keith J. Chappell, Daniel Watterson, Trent M. Woodruff
Publikováno v:
Molecular psychiatry.
Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however, an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe neurological manifestations, including precipitating cases of probable Parkinson
Autor:
Martin W. Lo, Alberto A. Amarilla, John D. Lee, Eduardo A. Albornoz, Naphak Modhiran, Richard J. Clark, Vito Ferro, Mohit Chhabra, Alexander A. Khromykh, Daniel Watterson, Trent M. Woodruff
The complement system has been heavily implicated in severe COVID-19 with clinical studies revealing widespread gene induction, deposition, and activation. However, the mechanism by which complement is activated in this disease remains incompletely u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a56909753a989c8ec2bb060a550a6f4
https://doi.org/10.1101/2022.01.11.475820
https://doi.org/10.1101/2022.01.11.475820
Autor:
Martin W Lo, Alberto A Amarilla, John D Lee, Eduardo A Albornoz, Naphak Modhiran, Richard J Clark, Vito Ferro, Mohit Chhabra, Alexander A Khromykh, Daniel Watterson, Trent M Woodruff
Publikováno v:
Clinical & Translational Immunology. 11
To determine whether SARS-CoV-2 can trigger complement activation, the pathways that are involved and the functional significance of the resultant effect.SARS-CoV-2 was inoculated into a human lepirudin-anticoagulated whole blood model, which contain
Autor:
Vandana Deora, Trent M. Woodruff, Richard D. Gordon, Eduardo A. Albornoz, Cyril J. Jagaraj, John D. Lee, Avril A. B. Robertson, Justin J. Yerbury, Julie D. Atkin, Kate Schroder, Mark E. Cooper, Luke McAlary
Publikováno v:
Glia. 68:407-421
Microglial NLRP3 inflammasome activation is emerging as a key contributor to neuroinflammation during neurodegeneration. Pathogenic protein aggregates such as β-amyloid and α-synuclein trigger microglial NLRP3 activation, leading to caspase-1 activ
Publikováno v:
Journal of Neuroimmune Pharmacology. 12:568-574
Parkinson's disease (PD) is recognized as the most common neurodegenerative movement disorder and results in debilitating motor deficits. The accumulation and spread of neurotoxic synuclein aggregates in the form of Lewy bodies is a key pathological
Publikováno v:
Experientia supplementum (2012). 108
Neuroinflammation is a common pathological feature in almost all neurological diseases and is a response triggered as a consequence of the chronic activation of the innate immune response in the CNS against a variety of stimuli, including infection,
Autor:
Avril A. B. Robertson, Dominic B. Rowe, Mark E. Cooper, Richard D. Gordon, Daniel C. Christie, Vinod Kumar, Luke A. J. O'Neill, Kate Schroder, Monica R. Langley, Eduardo A. Albornoz, Susanna Mantovani, Anumantha G. Kanthasamy, Mark S. Butler, Trent M. Woodruff
Publikováno v:
Science Translational Medicine. 10
Parkinson’s disease (PD) is characterized by a profound loss of dopaminergic neurons in the substantia nigra, accompanied by chronic neuroinflammation, mitochondrial dysfunction, and widespread accumulation of α-synuclein-rich protein aggregates i