Effects of a Fully Humanized Type II Anti-CD20 Monoclonal Antibody on Peripheral and CNS B Cells in a Transgenic Mouse Model of Multiple Sclerosis

Autor: Sabine Tacke, Rittika Chunder, Verena Schropp, Eduard Urich, Stefanie Kuerten

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 6, p 3172 (2022)

Successful therapy with anti-CD20 monoclonal antibodies (mAbs) has reinforced the key role of B cells in the immunopathology of multiple sclerosis (MS). This study aimed to determine the effects of a novel class of anti-CD20 mAbs on vascular and extr

Externí odkaz: https://doaj.org/article/74079c47786a4d048d578dae44441df0

Obinutuzumab-Induced B Cell Depletion Reduces Spinal Cord Pathology in a CD20 Double Transgenic Mouse Model of Multiple Sclerosis

Autor: Thomas Breakell, Sabine Tacke, Verena Schropp, Henrik Zetterberg, Kaj Blennow, Eduard Urich, Stefanie Kuerten

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 18, p 6864 (2020)

B cell-depleting therapies have recently proven to be clinically highly successful in the treatment of multiple sclerosis (MS). This study aimed to determine the effects of the novel type II anti-human CD20 (huCD20) monoclonal antibody (mAb) obinutuz

Externí odkaz: https://doaj.org/article/8a041cce063140998bfe924f1ebd8ec2

Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders

Autor: Julien Bryois, Daniela Calini, Will Macnair, Lynette Foo, Eduard Urich, Ward Ortmann, Victor Alejandro Iglesias, Suresh Selvaraj, Erik Nutma, Manuel Marzin, Sandra Amor, Anna Williams, Gonçalo Castelo-Branco, Vilas Menon, Philip De Jager, Dheeraj Malhotra

Publikováno v: Nature Neuroscience, 25(8), 1104-1112. Nature Publishing Group
Bryois, J, Calini, D, Macnair, W, Foo, L, Urich, E, Ortmann, W, Iglesias, V A, Selvaraj, S, Nutma, E, Marzin, M, Amor, S, Williams, A, Castelo-Branco, G, Menon, V, De Jager, P & Malhotra, D 2022, ' Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders ', Nature Neuroscience, vol. 25, no. 8, pp. 1104-1112 . https://doi.org/10.1038/s41593-022-01128-z

To date, most expression quantitative trait loci (eQTL) studies, which investigate how genetic variants contribute to gene expression, have been performed in heterogeneous brain tissues rather than specific cell types. In this study, we performed an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2001352763494c39c5cca9ed221bcc4a
http://www.scopus.com/inward/record.url?scp=85135229265&partnerID=8YFLogxK

A type II anti-CD20 monoclonal antibody efficiently depletes CNS B cells in a mouse model of multiple sclerosis

Autor: Verena Schropp, Rittika Chunder, Arif B. Ekici, Philipp Kirchner, Sabine Tacke, Stefanie Kuerten, Eduard Urich

BackgroundSuccessful therapy with anti-CD20 monoclonal antibodies (mAbs) has reinforced the key role of B cells in the immunopathology of multiple sclerosis. While treatment with currently available anti-CD20 mAbs results in rapid and robust eliminat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::320ee76d3cda25cdc81dfa42101dafe9
https://doi.org/10.21203/rs.3.rs-776877/v1

Impact of B cell-depletion on plasma cells in a pre-clinical model of meningeal inflammation and subpial demyelination

Autor: Angela Wang, Lesley Ward, Valeria Ramaglia, Eduard Urich, Jennifer L Gommerman

Publikováno v: The Journal of Immunology. 206:21.06-21.06

Anti-CD20 B cell depletion therapy has provided evidence for the pathogenic roles of B cells in multiple sclerosis (MS). Terminally differentiated plasma cells (PCs) are spared by anti-CD20, and our lab has previously shown that during experimental a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::84749bf82f459850c0950df85358cb99
https://doi.org/10.4049/jimmunol.206.supp.21.06