Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Eduard R. de Waard"'
1
Reduction of 1-(5-uracilylmethyl)pyridinium salts by thiols to thymine derivatives. A model of the thymidylate synthase reaction
Autor: Eduard R. de Waard, Upendra K. Pandit, E. Vega
Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 109:131-132
1-(5-uracilylmethyl)pyridinium salts react with 9, 10-dihydrophenanthridine, Hantzsch ester or thiols (RSH, R = p-nitrobenzyl, t-butyl) to form thymine derivatives. The mechanisms of the reactions are discussed.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::940fad869cb4f92bc8a857dac5d5f3e5
https://doi.org/10.1002/recl.19901090220
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2
Models of folate cofactors 17. Methylation of 1,3-dimethyl-6-methylamino-uracil by a 5,10-CH2-H4folate model. the first mimic of the overall dTMP synthase reaction
Autor: Eduard R. de Waard, Upendra K. Pandit, Paul F. C. van der Meij, Ellen Hilhorst, Tjoe B.R.A. Chen
Publikováno v: Tetrahedron. 43:4015-4021
2-Tosyl-1,2,3,12b-tetrahydroimidazo[1,5-f]lphenanthridine ( 6 ) was prepared in five steps from 6-chloromethylphenanthridine ( 1 ) in an overall yield of 50%. The reaction of 6 with 1,3-dimethyl-6-methylaminouracll ( 8 ) in CH 3 CN/TFA (100:1) at 50-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::50cdac10a43d2916bc54760660da4910
https://doi.org/10.1016/s0040-4020(01)81684-7
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8
A chemical model of thymidylate synthetase. Formation of a thymine derivative via an exocylic methylene intermediate
Autor: Paul F. C. van der Meij, Tjoe B.R.A. Chen, Ruth D. Lohmann, Eduard R. de Waard, Upendra K. Pandit
Publikováno v: Journal of the Chemical Society, Chemical Communications. :1229
Reaction of 6-aminouracil derivatives with imidazolidines (methylenetetrahydrofolate models), in the presence of acid, gives an exocyclic methylene intermediate which reacts with nucleophiles present in the mixture or can be reduced to a thymine deri
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ffeb8931317c3922f4da107e400457f
https://doi.org/10.1039/c39850001229
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9
The first example of a mimic of the overall thymidylate synthase reaction
Autor: Upendra K. Pandit, Tjoe B.R.A. Chen, Paul F. C. van der Meij, Eduard R. de Waard, Ellen Hilhorst
Publikováno v: Journal of the Chemical Society, Chemical Communications. :720
2-Tosyl-1,2,3,12b-tetrahydroimidazo[1,5-f]phenanthridine functions as a mimic of the cofactor 5,10-methylenetetrahydrofolate in transferring both a methylene moiety and a hydride equivalent (i.e. an overall methyl group) to the C-5 position of a urac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4fbab5e1ea1b83d501038d95692fd1a2
https://doi.org/10.1039/c39870000720
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10
Akademický článek
The first example of a mimic of the overall thymidylate synthase reaction.
Autor: van der Meij, Paul F. C., Chen, Tjoe B. R. A., Hilhorst, Ellen, de Waard, Eduard R., Pandit, Upendra K.
Publikováno v: Journal of the Chemical Society, Chemical Communications; 5/15/1987, Issue 10, p720-721, 2p
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