Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Eduard J, Kerkhoven"'
Autor:
Chengyu Zhang, Benjamín J Sánchez, Feiran Li, Cheng Wei Quan Eiden, William T Scott, Ulf W Liebal, Lars M Blank, Hendrik G Mengers, Mihail Anton, Albert Tafur Rangel, Sebastián N Mendoza, Lixin Zhang, Jens Nielsen, Hongzhong Lu, Eduard J Kerkhoven
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 10, Pp 1134-1150 (2024)
Abstract Genome-scale metabolic models (GEMs) can facilitate metabolism-focused multi-omics integrative analysis. Since Yeast8, the yeast-GEM of Saccharomyces cerevisiae, published in 2019, has been continuously updated by the community. This has inc
Externí odkaz:
https://doaj.org/article/6ceac2e6fd9f4f218e5ca5c7ed65211e
Autor:
Behnaz Nowrouzi, Pablo Torres-Montero, Eduard J. Kerkhoven, José L. Martínez, Leonardo Rios-Solis
Publikováno v:
Metabolic Engineering Communications, Vol 18, Iss , Pp e00229- (2024)
Saccharomyces cerevisiae has been conveniently used to produce Taxol® anticancer drug early precursors. However, the harmful impact of oxidative stress by the first cytochrome P450-reductase enzymes (CYP725A4-POR) of Taxol® pathway has hampered suf
Externí odkaz:
https://doaj.org/article/8b15fb22fd7246e281e56e56c65f6c83
Autor:
Amanda Sörensen Ristinmaa, Albert Tafur Rangel, Alexander Idström, Sebastian Valenzuela, Eduard J. Kerkhoven, Phillip B. Pope, Merima Hasani, Johan Larsbrink
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract The bark is the outermost defense of trees against microbial attack, largely thanks to toxicity and prevalence of extractive compounds. Nevertheless, bark decomposes in nature, though by which species and mechanisms remains unknown. Here, we
Externí odkaz:
https://doaj.org/article/de933eafb49e43a5b55d0e7503e1da82
Autor:
Koray Malcı, Rodrigo Santibáñez, Nestor Jonguitud-Borrego, Jorge H. Santoyo-Garcia, Eduard J. Kerkhoven, Leonardo Rios-Solis
Publikováno v:
Microbial Cell Factories, Vol 22, Iss 1, Pp 1-22 (2023)
Abstract Background Integrated metabolic engineering approaches that combine system and synthetic biology tools enable the efficient design of microbial cell factories for synthesizing high-value products. In this study, we utilized in silico design
Externí odkaz:
https://doaj.org/article/fdc1b98f6ef149f0adb312ed2f365ef2
Autor:
Álvaro Pérez-Valero, Juan Serna-Diestro, Albert Tafur Rangel, Simona Barbuto Ferraiuolo, Chiara Schiraldi, Eduard J. Kerkhoven, Claudio J. Villar, Felipe Lombó
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 7, p 4053 (2024)
Flavonoids exhibit various bioactivities including anti-oxidant, anti-tumor, anti-inflammatory, and anti-viral properties. Methylated flavonoids are particularly significant due to their enhanced oral bioavailability, improved intestinal absorption,
Externí odkaz:
https://doaj.org/article/380da9bed1fe493686f3a1f9dbf83173
Autor:
Iván Domenzain, Benjamín Sánchez, Mihail Anton, Eduard J. Kerkhoven, Aarón Millán-Oropeza, Céline Henry, Verena Siewers, John P. Morrissey, Nikolaus Sonnenschein, Jens Nielsen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Abstract Genome-scale metabolic models (GEMs) have been widely used for quantitative exploration of the relation between genotype and phenotype. Streamlined integration of enzyme constraints and proteomics data into such models was first enabled by t
Externí odkaz:
https://doaj.org/article/2c658bb1c7854350acfe1f06f530ec04
Autor:
Alīna Reķēna, Marina J Pinheiro, Nemailla Bonturi, Isma Belouah, Eliise Tammekivi, Koit Herodes, Eduard J Kerkhoven, Petri-Jaan Lahtvee
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 4, p e1011009 (2023)
Rhodotorula toruloides is a non-conventional, oleaginous yeast able to naturally accumulate high amounts of microbial lipids. Constraint-based modeling of R. toruloides has been mainly focused on the comparison of experimentally measured and model pr
Externí odkaz:
https://doaj.org/article/7a49e4a18eee493d90f21122c51fae22
Autor:
Feiran Li, Yu Chen, Qi Qi, Yanyan Wang, Le Yuan, Mingtao Huang, Ibrahim E. Elsemman, Amir Feizi, Eduard J. Kerkhoven, Jens Nielsen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Due to the complexity of the protein secretory pathway, strategy suitable for the production of a certain recombination protein cannot be generalized. Here, the authors construct a proteome-constrained genome-scale protein secretory model for yeast a
Externí odkaz:
https://doaj.org/article/3d0cd4e6158c4b949523fcbf3bf56972
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105703- (2022)
Summary: Media components, including the nitrogen source, are significant cost factors in cultivation processes. The nitrogen source also influences cell behavior and production performance. Ammonium sulfate is a widely used nitrogen source for micro
Externí odkaz:
https://doaj.org/article/f247aa6c3a0c4bdd8e3ea8ff5191cd2a
Autor:
Hongzhong Lu, Feiran Li, Le Yuan, Iván Domenzain, Rosemary Yu, Hao Wang, Gang Li, Yu Chen, Boyang Ji, Eduard J Kerkhoven, Jens Nielsen
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 10, Pp 1-23 (2021)
Abstract Yeasts are known to have versatile metabolic traits, while how these metabolic traits have evolved has not been elucidated systematically. We performed integrative evolution analysis to investigate how genomic evolution determines trait gene
Externí odkaz:
https://doaj.org/article/1b0b1695d181441c8971f35c8d7fd4cc