Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Eduard G. Casillas"'
Publikováno v:
Tetrahedron. 69:9994-10002
A convergent synthesis applicable to the preparation of oxidized prenylchalcones is reported that relies on key Claisen–Schmidt, Mitsunobu, and vinyl/benzyl Stille coupling operations. The synthetic strategy was applied towards the preparation of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bd9f43f374c1690f29ec81db687d04d
https://doi.org/10.1016/j.tet.2013.09.068
https://doi.org/10.1016/j.tet.2013.09.068
Autor:
Heidi L. Shimp, Eduard G. Casillas, Catherine E. Leimkuhler, Lindsay A. Curtis, Justin K. Belardi, Steven S. Clareen, Nicole L. Simonowicz
Publikováno v:
Synthetic Communications. 35:1633-1640
A short, scalable route to 4‐hydroxymethylcyclopent‐2‐enone, based upon a silicon‐directed Nazarov cyclization, is described. Noteworthy in this study is the success of the cyclization with an oxygenated substrate.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eda4260d372d5b85ebf0dcf772b1830a
https://doi.org/10.1081/scc-200061633
https://doi.org/10.1081/scc-200061633
Autor:
Eduard G. Casillas, Joseph J. Romano
Publikováno v:
Tetrahedron Letters. 46:2323-2326
Advanced C-prenylated intermediates for three aromatase inhibitors, including morachalcone A, can be synthesized through a Claisen–Schmidt condensation followed by Florisil®-catalyzed [1,3]-sigmatropic rearrangement of a prenyl phenyl ether.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d338713573db7464f59a3978e21b0707
https://doi.org/10.1016/j.tetlet.2005.01.174
https://doi.org/10.1016/j.tetlet.2005.01.174
Autor:
Eduard G. Casillas, Kristen N. Carey, Kushol Gupta, Carl J. Kaub, Patrick J. Loll, Barry S. Selinsky
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:667-671
The nonsteroidal anti-inflammatory drugs flurbiprofen and ibuprofen were modified in an attempt to alter the kinetics of inhibitor binding by COX-1. Contrary to prior predictions, a halogen substituent is not sufficient to confer slow tight-binding b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c22483af1e77bd07c375e1a844ba04
https://doi.org/10.1016/j.bmcl.2003.11.034
https://doi.org/10.1016/j.bmcl.2003.11.034
Publikováno v:
ChemInform. 45
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f481f04ddddffef63482b46429227bdb
https://doi.org/10.1002/chin.201415233
https://doi.org/10.1002/chin.201415233
Publikováno v:
Journal of the American Chemical Society. 121:7729-7746
The biosynthetic pathway to the potent mycotoxin aflatoxin B1 is unusually long and complex, proceeding from anthraquinone to xanthone to coumarin nuclear types bearing fused tetrahydro- and bisdihydrofuran rings. A synthetic strategy is described in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23bc807ef625a076623f012b5d4cc62c
https://doi.org/10.1021/ja990591x
https://doi.org/10.1021/ja990591x
Publikováno v:
ChemInform. 30
The biosynthetic pathway to the potent mycotoxin aflatoxin B1 is unusually long and complex, proceeding from anthraquinone to xanthone to coumarin nuclear types bearing fused tetrahydro- and bisdihydrofuran rings. A synthetic strategy is described in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35aca0923f417d3ccc88f5ae98be1d18
https://doi.org/10.1002/chin.199952234
https://doi.org/10.1002/chin.199952234
Publikováno v:
Biochemistry. 35(35)
The absolute configuration of the dihydrobisfuran ring system characteristic of aflatoxin B1 is essential to the covalent reaction of its metabolically activated form with double-stranded DNA. The biosynthesis of this potent mycotoxin proceeds throug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d972fb30752dee0dbaa4dd7fb33151d0
https://pubmed.ncbi.nlm.nih.gov/8784203
https://pubmed.ncbi.nlm.nih.gov/8784203