Biocatalytic production of alpha-hydroxy ketones and vicinal diols by yeast and human aldo–keto reductases

Autor: Jaume Farrés, M. Rosario Fernández, Sergio Porté, Eduard Calam, Josep A. Biosca, Xavier Parés

Publikováno v: Chemico-Biological Interactions. 202:195-203

The α-hydroxy ketones are used as building blocks for compounds of pharmaceutical interest (such as antidepressants, HIV-protease inhibitors and antitumorals). They can be obtained by the action of enzymes or whole cells on selected substrates, such

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::395d8c5c8cfe44713a86a7cecad4c31c
https://doi.org/10.1016/j.cbi.2012.12.006

Role of Saccharomyces cerevisiae Oxidoreductases Bdh1p and Ara1p in the Metabolism of Acetoin and 2,3-Butanediol

Autor: Didac Marco, Eva González, Sylvie Dequin, Josep A. Biosca, Eduard Calam, M. Rosario Fernández, Lauro Sumoy, Xavier Parés

Publikováno v: Applied and Environmental Microbiology
Applied and Environmental Microbiology, American Society for Microbiology, 2010, 76 (3), pp.670-679. ⟨10.1128/AEM.01521-09⟩

NAD-dependent butanediol dehydrogenase (Bdh1p) from Saccharomyces cerevisiae reversibly transforms acetoin to 2,3-butanediol in a stereospecific manner. Deletion of BDH1 resulted in an accumulation of acetoin and a diminution of 2,3-butanediol in two

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73115fbff44366ae9435621da38dbec
https://hal.inrae.fr/hal-02664404