Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Eduard, Post"'
Autor:
Christina Draijer, Laura Florez-Sampedro, Catharina Reker-Smit, Eduard Post, Fransien van Dijk, Barbro N. Melgert
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionDifferentially polarized macrophages, especially YM1+ and MHCII+ macrophages, play an important role in asthma development. The origin of these polarized macrophages has not been elucidated yet. We therefore aimed to investigate how proli
Externí odkaz:
https://doaj.org/article/ae9cb35b0b4a4c2fb8af71dd99b4d8c3
Autor:
Marlies Schippers, Eduard Post, Ilse Eichhorn, Jitske Langeland, Leonie Beljaars, Madhu S. Malo, Richard A. Hodin, José Luis Millán, Yury Popov, Detlef Schuppan, Klaas Poelstra
Publikováno v:
Cells, Vol 9, Iss 12, p 2708 (2020)
Alkaline phosphatase (AP) activity is highly upregulated in plasma during liver diseases. Previously, we demonstrated that AP is able to detoxify lipopolysaccharide (LPS) by dephosphorylating its lipid A moiety. Because a role of gut-derived LPS in l
Externí odkaz:
https://doaj.org/article/aae3939d90614fc7bf583d46f08fcfc8
Autor:
Adhyatmika Adhyatmika, Leonie Beljaars, Kurnia S. S. Putri, Habibie Habibie, Carian E. Boorsma, Catharina Reker-Smit, Theerut Luangmonkong, Burak Guney, Axel Haak, Keri A. Mangnus, Eduard Post, Klaas Poelstra, Kim Ravnskjaer, Peter Olinga, Barbro N. Melgert
Publikováno v:
Pharmaceutics, Vol 12, Iss 5, p 471 (2020)
Osteoprotegerin (OPG) serum levels are associated with liver fibrogenesis and have been proposed as a biomarker for diagnosis. However, the source and role of OPG in liver fibrosis are unknown, as is the question of whether OPG expression responds to
Externí odkaz:
https://doaj.org/article/b319b910af32449c8e3333c092aedcec
Autor:
Fransien van Dijk, Christa M. Hazelhoff, Eduard Post, Gerian G. H. Prins, Krista Rombouts, Klaas Poelstra, Peter Olinga, Leonie Beljaars
Publikováno v:
Pharmaceutics, Vol 12, Iss 3, p 278 (2020)
The pivotal cell involved in the pathogenesis of liver fibrosis, i.e., the activated hepatic stellate cell (HSC), has a wide range of activities during the initiation, progression and even regression of the disease. These HSC-related activities encom
Externí odkaz:
https://doaj.org/article/283deb78998c4f798070fce8ae0faaa4
Autor:
Jai Prakash, Ruchi Bansal, Eduard Post, Alie de Jager-Krikken, Marjolijn N. Lub-de Hooge, Klaas Poelstra
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 11, Iss 12, Pp 1348-1358 (2009)
15-Deoxy-Δ12,14-prostaglandin-J2 (15d-PGJ2), a peroxisome proliferator-activated receptor γ (PPARγ) agonist, induces cell death in tumor cells in vitro; however, no study showed its in vivo effect on tumors. Here, we report that 15d-PGJ2 shows ant
Externí odkaz:
https://doaj.org/article/9b94de92e011488898c31f2e0e59b877
Autor:
Klaas Poelstra, Matthias H. M. Klose, Angela Casini, F. van Dijk, Leonie Beljaars, Niels J. Sijbrandi, Samuel M. Meier-Menches, Eduard Post, Peter Olinga, Detlef Schuppan, Yong Ook Kim, Peter Horvatovich, Wouter L. J. Hinrichs, Naomi Teekamp, Johan Zuidema, Rob Steendam, Hendrik W. Frijlink
Publikováno v:
Journal of Controlled Release, 296, 250-257. Elsevier Bedrijfsinformatie b.v.
Rho kinase activity in hepatic stellate cells (HSCs) is associated with activation, transformation and contraction of these cells, leading to extracellular matrix production and portal hypertension in liver cirrhosis. Inhibition of rho kinase activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e32fbe853d5c3858aa46577f4d6af2e
https://research.rug.nl/en/publications/125e52bd-45b3-47c2-9f0c-0e083c2f927a
https://research.rug.nl/en/publications/125e52bd-45b3-47c2-9f0c-0e083c2f927a
Autor:
Yury Popov, Jitske Langeland, Eduard Post, Leonie Beljaars, Detlef Schuppan, Madhu S. Malo, Marlies Schippers, Ilse Eichhorn, Richard A. Hodin, Klaas Poelstra, José Luis Millán
Publikováno v:
Cells, 9(12):2708. MDPI AG
Cells, Vol 9, Iss 2708, p 2708 (2020)
Cells
Volume 9
Issue 12
Cells, Vol 9, Iss 2708, p 2708 (2020)
Cells
Volume 9
Issue 12
Alkaline phosphatase (AP) activity is highly upregulated in plasma during liver diseases. Previously, we demonstrated that AP is able to detoxify lipopolysaccharide (LPS) by dephosphorylating its lipid A moiety. Because a role of gut-derived LPS in l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a19821604fd9df41ea75d1cf10f9bb8
https://research.rug.nl/en/publications/a142ca28-aa35-4301-91f3-da7128303d3b
https://research.rug.nl/en/publications/a142ca28-aa35-4301-91f3-da7128303d3b
Autor:
Marike Marjolijn van Beuge, Jai Prakash, Marie Lacombe, Eduard Post, Catharina Reker-Smit, Leonie Beljaars, Klaas Poelstra
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56442 (2013)
Transforming growth factor-β (TGF-β) is a major pro-fibrotic cytokine, causing the overproduction of extracellular matrix molecules in many fibrotic diseases. Inhibition of its type-I receptor (ALK5) has been shown to effectively inhibit fibrosis i
Externí odkaz:
https://doaj.org/article/9869142f40a04ce494f7fc4c90a4e6b5
Autor:
Krista Rombouts, Fransien van Dijk, Christa M. Hazelhoff, Peter Olinga, Gerian G. H. Prins, Klaas Poelstra, Eduard Post, Leonie Beljaars
Publikováno v:
Pharmaceutics, 12(3):278. MDPI AG
Pharmaceutics
Volume 12
Issue 3
Pharmaceutics, Vol 12, Iss 3, p 278 (2020)
Pharmaceutics
Volume 12
Issue 3
Pharmaceutics, Vol 12, Iss 3, p 278 (2020)
The pivotal cell involved in the pathogenesis of liver fibrosis, i.e., the activated hepatic stellate cell (HSC), has a wide range of activities during the initiation, progression and even regression of the disease. These HSC-related activities encom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1f53d6e3e07c9538013e798350524b3
https://research.rug.nl/en/publications/0d6ed204-3ebe-4315-a3ee-8872118e55f1
https://research.rug.nl/en/publications/0d6ed204-3ebe-4315-a3ee-8872118e55f1
Autor:
Annemarie Broesder, Klaas Poelstra, Peter Olinga, F. van Dijk, Eduard Post, M. Evers, Jan-Luuk Hillebrands, Henderik W. Frijlink, Johan Zuidema, Wouter L. J. Hinrichs, Naomi Teekamp, Rob Steendam, Leonie Beljaars
Publikováno v:
International Journal of Pharmaceutics, 534(1-2), 229-236. Elsevier Bedrijfsinformatie b.v.
Injectable sustained release drug delivery systems are an attractive alternative for the intravenous delivery of therapeutic proteins. In particular, for chronic diseases such as fibrosis, this approach could improve therapy by reducing the administr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f267cbced933153c7a7729638dcd58a8
https://research.rug.nl/en/publications/a60ad7df-0cc8-4b96-b869-bdc9f2ef25d2
https://research.rug.nl/en/publications/a60ad7df-0cc8-4b96-b869-bdc9f2ef25d2