Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Eduard, Bentea"'
Autor:
Eduard Bentea, Laura De Pauw, Lise Verbruggen, Lila C. Winfrey, Lauren Deneyer, Cynthia Moore, Giulia Albertini, Hideyo Sato, Ann Van Eeckhaut, Charles K. Meshul, Ann Massie
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
The astrocytic cystine/glutamate antiporter system xc– (with xCT as the specific subunit) imports cystine in exchange for glutamate and has been shown to interact with multiple pathways in the brain that are dysregulated in age-related neurological
Externí odkaz:
https://doaj.org/article/a6d327e1e24344a8926ec84d90535739
Autor:
Lise Verbruggen, Lindsay Sprimont, Eduard Bentea, Pauline Janssen, Azzedine Gharib, Lauren Deneyer, Laura De Pauw, Olaya Lara, Hideyo Sato, Charles Nicaise, Ann Massie
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Despite ample evidence for the therapeutic potential of inhibition of the cystine/glutamate antiporter system xc− in neurological disorders and in cancer, none of the proposed inhibitors is selective. In this context, a lot of research has been per
Externí odkaz:
https://doaj.org/article/e5c8b01f7c4943ae966ece9e1e32fa8f
Autor:
Erica A K DePasquale, Khaled Alganem, Eduard Bentea, Nawshaba Nawreen, Jennifer L McGuire, Tushar Tomar, Faris Naji, Riet Hilhorst, Jaroslaw Meller, Robert E McCullumsmith
Publikováno v:
PLoS ONE, Vol 16, Iss 12, p e0260440 (2021)
Phosphorylation by serine-threonine and tyrosine kinases is critical for determining protein function. Array-based platforms for measuring reporter peptide signal levels allow for differential phosphorylation analysis between conditions for distinct
Externí odkaz:
https://doaj.org/article/fbeae036ba4e4805806f7b1078411edb
Autor:
Lise Verbruggen, Gamze Ates, Olaya Lara, Jolien De Munck, Agnès Villers, Laura De Pauw, Sigrid Ottestad-Hansen, Sho Kobayashi, Pauline Beckers, Pauline Janssen, Hideyo Sato, Yun Zhou, Emmanuel Hermans, Rose Njemini, Lutgarde Arckens, Niels C. Danbolt, Dimitri De Bundel, Joeri L. Aerts, Kurt Barbé, Benoit Guillaume, Laurence Ris, Eduard Bentea, Ann Massie
Publikováno v:
Molecular Psychiatry, (2022)
The cystine/glutamate antiporter system xc− has been identified as the major source of extracellular glutamate in several brain regions as well as a modulator of neuroinflammation, and genetic deletion of its specific subunit xCT (xCT−/−) is pr
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 12 (2018)
Parkinson’s disease (PD) is an age-related neurodegenerative condition characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). A loss of proteasome function participates to the pathogenesis of PD, l
Externí odkaz:
https://doaj.org/article/aeb766347d434ef2a7cf40415c3e9cc1
Autor:
Pauline Janssen, Laurence Ris, Ann Massie, Charles K. Meshul, Olaya Lara, Lutgarde Arckens, Emmanuel Hermans, Robert E. McCullumsmith, Lise Verbruggen, Madeline J Churchill, Hideyo Sato, Noemi Declerck, Adam J. Funk, Cynthia Moore, Sinead M. O’Donovan, Eduard Bentea, Laura De Pauw, Agnès Villers, Erica A K DePasquale
Publikováno v:
Molecular Psychiatry, Vol. 26, no. 9, p. 4754-4769 (2021)
Molecular psychiatry
Molecular psychiatry
The astrocytic cystine/glutamate antiporter system xc− represents an important source of extracellular glutamate in the central nervous system, with potential impact on excitatory neurotransmission. Yet, its function and importance in brain physiol
Autor:
Erica A. K. DePasquale, Khaled Alganem, Eduard Bentea, Nawshaba Nawreen, Jennifer L. McGuire, Tushar Tomar, Faris Naji, Riet Hilhorst, Jaroslaw Meller, Robert E. McCullumsmith
Publikováno v:
PLoS ONE, Vol 16, Iss 12, p e0260440 (2021)
PLoS ONE
PLoS ONE
Phosphorylation by serine-threonine and tyrosine kinases is critical for determining protein function. Array-based platforms for measuring reporter peptide signal levels allow for differential phosphorylation analysis between conditions for distinct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd0699c9fc9d5d5dc7eb9a742a1f52c
https://lirias.kuleuven.be/handle/20.500.12942/688811
https://lirias.kuleuven.be/handle/20.500.12942/688811
Autor:
Lise, Verbruggen, Gamze, Ates, Olaya, Lara, Jolien, De Munck, Agnès, Villers, Laura, De Pauw, Sigrid, Ottestad-Hansen, Sho, Kobayashi, Pauline, Beckers, Pauline, Janssen, Hideyo, Sato, Yun, Zhou, Emmanuel, Hermans, Rose, Njemini, Lutgarde, Arckens, Niels C, Danbolt, Dimitri, De Bundel, Joeri L, Aerts, Kurt, Barbé, Benoit, Guillaume, Laurence, Ris, Eduard, Bentea, Ann, Massie
Publikováno v:
Molecular psychiatry. 27(4)
The cystine/glutamate antiporter system x
Publikováno v:
Current opinion in neurobiology. 72
Genes associated with endolysosomal function have been recently associated with familial Parkinson's disease and described as risk factors for sporadic cases. This indicates that deficits in this pathway predispose to parkinsonism. To better understa
Autor:
Lindsay Sprimont, Lauren Deneyer, Pauline Janssen, Olaya Lara, Azzedine Gharib, Ann Massie, Charles Nicaise, Hideyo Sato, Lise Verbruggen, Eduard Bentea, Laura De Pauw
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 12 (2021)
Verbruggen, L, Sprimont, L, Bentea, E, Janssen, P, Gharib, A, Deneyer, L, De Pauw, L, Lara, O, Sato, H, Nicaise, C & Massie, A 2021, ' Chronic sulfasalazine treatment in mice induces system xc--independent adverse effects ', Frontiers in Pharmacology, vol. 12, 625699 . https://doi.org/10.3389/fphar.2021.625699
Frontiers in Pharmacology, Vol 12 (2021)
Verbruggen, L, Sprimont, L, Bentea, E, Janssen, P, Gharib, A, Deneyer, L, De Pauw, L, Lara, O, Sato, H, Nicaise, C & Massie, A 2021, ' Chronic sulfasalazine treatment in mice induces system xc--independent adverse effects ', Frontiers in Pharmacology, vol. 12, 625699 . https://doi.org/10.3389/fphar.2021.625699
Despite ample evidence for the therapeutic potential of inhibition of the cystine/glutamate antiporter system xc− in neurological disorders and in cancer, none of the proposed inhibitors is selective. In this context, a lot of research has been per